Automated anterior chamber angle pigmentation analyses using 360° gonioscopy.
Matsuo Masato, Pajaro Simone, De Giusti Andrea, Tanito Masaki
AI Summary
Automated 360° gonioscopy accurately graded angle pigmentation, showing good agreement with manual methods and confirming higher pigmentation inferiorly, which could aid glaucoma assessment.
Abstract
Purpose
To assess the pigmentation distribution in the iridocorneal angle using an established algorithm with gonioscopically obtained images.
Methods
Manual and automatically modified Scheie's pigmentation grading (ie, 0/I=0, II=1 and III/IV=2) of trabecular meshwork was performed using an established algorithm on the 75 open-angle eyes of 75 subjects obtained by automated gonioscopy. All images were collected at the Matsue Red Cross Hospital in 2016. The differences in the pigmentation density were compared statistically between the automated and manual techniques and among the four sectors (ie, inferior, superior, temporal and nasal) and the four quadrants.
Results
There was substantial agreement between both grading methods (kappa value=0.70). There was no significant difference between the automated and manual grading in any sectors except for the superior (p=0.0004). The automated pigmentation grade was significantly (p<0.05) higher in the inferior sector (mean grade, 1.43) than in the others (mean grade, 0.48~0.76), and it was also significantly (p<0.05) higher in the inferior quadrant (mean grade, 3.56) than in the others (mean grade, 1.64~2.24). The findings were similar for manual grading.
Conclusions
The entire distribution of the pigmentation in the anterior chamber angle was classified successfully using the algorithm, and the automated versus manual grading comparison showed good agreement. The automated pigmentation grading scores in the inferior sector and inferior quadrant were significantly higher than in the others as previously reported. Similar findings also were seen for manual grading.
MeSH Terms
Shields Classification
Key Concepts5
There was substantial agreement between automated and manual Scheie's pigmentation grading methods for trabecular meshwork (kappa value=0.70) in 75 open-angle eyes of 75 subjects.
There was no significant difference between automated and manual pigmentation grading in any sectors, except for the superior sector (p=0.0004), in 75 open-angle eyes of 75 subjects using 360° gonioscopy.
Automated pigmentation grading scores in the inferior sector (mean grade, 1.43) were significantly higher (p<0.05) than in other sectors (mean grade, 0.48~0.76) in 75 open-angle eyes of 75 subjects.
Automated pigmentation grading scores in the inferior quadrant (mean grade, 3.56) were significantly higher (p<0.05) than in other quadrants (mean grade, 1.64~2.24) in 75 open-angle eyes of 75 subjects.
Manual pigmentation grading showed similar findings to automated grading, with significantly higher scores in the inferior sector and inferior quadrant, in 75 open-angle eyes of 75 subjects.
Related Articles5
The Structural Layers of the Porcine Iris Exhibit Inherently Different Biomechanical Properties.
Basic ScienceElevated IGF-1 and GH Levels Are Correlated With a Thicker Iris and Wider Anterior Chamber Angle in Treatment-Naïve Acromegaly Patients.
Case-Control StudyIris Color Matters-A Contractility Analysis With Dynamic Volume-Rendered Optical Coherence Tomography Pupillometry.
Observational StudyDecreased iris thickness on swept-source optical coherence tomography in patients with primary open-angle glaucoma.
Cross-Sectional StudyPigment dispersion syndrome and its implications for glaucoma.
ReviewIs this article assigned to the wrong chapter(s)? Let us know.