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Section I · Basic Aspects

Chapter 3: Gonioscopy and Other Techniques for Assessing the Anterior Segment

Shields' Textbook of Glaucoma, 6th edition

Showing 1–20 of 921 articles

5.
Observational Study

Anterior Chamber Angle Changes and Surgical Outcomes After Combined Phacoemulsification and High-Frequency Deep Sclerotomy: A Prospective AS-OCT Study.

Orenc Pinar, Kuçukbezirci Guldeniz Usta, Gungel Hulya

J GlaucomaFeb 2026

This study found combined phacoemulsification and HFDS successfully lowered IOP. Postoperative AS-OCT showed angle widening, with 750-µm posterior angle measurements potentially indicating surgical success, aiding long-term glaucoma follow-up.

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Male participants with axial myopia showed a weaker peak pupillary constriction ratio (32.99 ± 4.85%) compared with females (36.15 ± 5.21%, P = 0.0143).

PrognosisCross-sectionalCross-sectional studyn=62 patients (50% male)

In young individuals with axial myopia, constriction period metrics (peak ratio, time, mean velocity, and maximum velocity) showed no correlation with axial length (AL).

MechanismCross-sectionalCross-sectional studyn=62 patients

In young individuals with axial myopia, the maximum constriction velocity was positively affected by the ganglion cell-inner plexiform layers (GCIPL) and the entire retinal thickness in most outer annular regions (all P < 0.05).

MechanismCross-sectionalCross-sectional studyn=62 patients

In young individuals with axial myopia, accelerated pupillary dilation time was affected by both higher axial length (AL) (β=-0.256 s/mm, P = 0.038) and thicker macular retinal nerve fiber layer (mRNFL) thickness, especially in inner nasal, and outer nasal region (both P < 0.05).

MechanismCross-sectionalCross-sectional studyn=62 patients

In male participants with axial myopia, the peak pupil constriction ratio was affected by similar outer annular regions in the ganglion cell-inner plexiform layers (GCIPL) and entire retinal thickness (all P < 0.05).

MechanismCross-sectionalCross-sectional studyn=31 male patients

In worse eyes of NTG-OSA patients, mean blur rate for tissue (MT) was less in the lower lateral decubitus (LD) position (9.00 ± 2.07 au) compared to the upper LD position (9.27 ± 1.97 au; P = 0.037) and supine position (9.61 ± 1.95 au; P = 0.011), suggesting reduced optic nerve head blood flow velocity in the lower LD position.

MechanismCross-sectionalCross-sectional studyn=40 NTG-OSA patients

Among NTG-OSA participants who slept with the worse eye lower, mean blur rates for vascular (MV), tissue (MT), and entire area (MA) were less in the worse eyes in both lower and upper lateral decubitus (LD) positions versus the fellow eye (all P < 0.05), but not in the supine position.

MechanismCross-sectionalCross-sectional studyn=40 NTG-OSA patients

Among NTG-OSA participants who slept with the worse eye upper, mean blur rates for vascular (MV) and tissue (MT) were less in the worse eyes only in the lower lateral decubitus (LD) position (both P < 0.05), with no differences in other positions.

MechanismCross-sectionalCross-sectional studyn=40 NTG-OSA patients

Adults with sickle cell disease (SCD) without glaucoma showed thinner Bruch's membrane opening-minimum rim width (BMO-MRW), peripapillary retinal nerve fibre layer (RNFL), and macular ganglion cell complex (GCC) compared with controls (all p < 0.001).

DiagnosisCross-sectionalMonocentric, retrospective cross-sectional studyn=185 eyes from 96 adults with SCD and 40 eyes from 20 controls

Within sickle cell disease (SCD) patients, HbSC genotype exhibited greater optic nerve thinning than HbSS genotype, specifically in temporal and superonasal BMO-MRW sectors and RNFL average, inferotemporal, and superotemporal sectors.

PrognosisCross-sectionalMonocentric, retrospective cross-sectional studyn=116 eyes from 59 HbSS patients; 69 eyes from 37 HbSC patients

Proliferative sickle cell retinopathy (SCR) showed more pronounced optic nerve loss than non-proliferative disease, including lower BMO-MRW, temporal RNFL thinning, and global GCC reduction.

PrognosisCross-sectionalMonocentric, retrospective cross-sectional studyn=185 eyes from 96 adults with SCD

Older age, recent acute chest syndrome, and ≥1 vaso-occlusive crisis within 2 years independently increased the odds of subclinical structural optic neuropathy (SON) in adults with sickle cell disease, whereas higher haemoglobin was protective.

PrognosisCross-sectionalMonocentric, retrospective cross-sectional studyn=185 eyes from 96 adults with SCD