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Section I · Basic Aspects

Chapter 2: Intraocular Pressure and Tonometry

Shields' Textbook of Glaucoma, 6th edition

Showing 1–20 of 5,284 articles

15.
Systematic Review

Slow-Coagulation Cyclophotocoagulation versus Conventional Continuous Wave Cyclophotocoagulation and Micropulse Cyclophotocoagulation for the Treatment of Glaucoma: A Systematic Review and Meta-analysis.

Narainswami Neeran, Chavez Matheus Pedrotti, Sperotto Pedro Henrique Ferrazza et al.

J GlaucomaMar 2026

This study found slow-coagulation cyclophotocoagulation lowers eye pressure more than micropulse, similarly to continuous wave, with comparable safety. It's a viable non-incisional glaucoma treatment option.

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Anterior scleral thickness at 0-3mm from the scleral spur (AST0) was significantly lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls in both nasal and temporal quadrants (all p < 0.001).

DiagnosisCross-sectionalProspective Cross-sectional Studyn=126 participants (56 POAG, 24 OHT, 46 controls)

Schlemm's canal area (SCA) and scleral spur length (SSL) were significantly lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls in both nasal and temporal quadrants (all p < 0.001).

DiagnosisCross-sectionalProspective Cross-sectional Studyn=126 participants (56 POAG, 24 OHT, 46 controls)

In multivariable analysis, nasal Schlemm's canal area (SCA) and nasal scleral spur length (SSL) were independent positive predictors of nasal anterior scleral thickness at 0-3mm from the scleral spur (AST0) (both p < 0.001; model R² = 0.356).

MechanismCross-sectionalProspective Cross-sectional Studyn=126 participants (56 POAG, 24 OHT, 46 controls)

For anterior scleral thickness at 3mm from the scleral spur (AST3), temporal values were lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls (p < 0.001), while nasal AST3 showed no significant group difference.

DiagnosisCross-sectionalProspective Cross-sectional Studyn=126 participants (56 POAG, 24 OHT, 46 controls)

Inter-observer intraclass correlation coefficients (ICCs) for measurements ranged from 0.78-0.93, with the highest for nasal Schlemm's canal area (SCA) at 0.93, indicating good repeatability for the spectral-domain OCT (SD-OCT) evaluation method.

MethodologyCross-sectionalProspective Cross-sectional Studyn=126 participants (56 POAG, 24 OHT, 46 controls)

The study included 126 participants (56 primary open-angle glaucoma, 24 ocular hypertension, 46 controls) from a tertiary glaucoma clinic between January and May 2025, with one eye per subject analyzed using spectral-domain OCT (REVO 60, Optopol, Poland) for anterior segment scans.

MethodologyCross-sectionalProspective Cross-sectional Studyn=126 participants (56 POAG, 24 OHT, 46 controls)

Multivariable stepwise linear regression models and changepoint analysis showed that below a trabecular iris space area (TISA750) measurement of 0.08 mm2, models became increasingly predictive of intraocular pressure (IOP) up to an adjusted R2 of 0.84.

DiagnosisCross-sectionalCross-sectional studyn=2,360 eyes of 2,360 participants

Smaller trabecular iris space area (TISA750) and iris area (IA) were consistently associated (P≤0.04) with higher intraocular pressure (IOP) for TISA750 below 0.20, 0.10, and 0.05 mm2 in 2,360 eyes of 2,360 Chinese American Eye Study participants.

DiagnosisCross-sectionalCross-sectional studyn=2,360 eyes of 2,360 participants

In multivariable models of ocular hypertension (OHTN) (AUC≤0.95), smaller trabecular iris space area (TISA750) was associated with OHTN for TISA750 less than 0.20, 0.10, and 0.05 mm2 (P≤0.03) in 2,360 eyes of 2,360 Chinese American Eye Study participants.

DiagnosisCross-sectionalCross-sectional studyn=2,360 eyes of 2,360 participants

Smaller iris area (IA) was associated with ocular hypertension (OHTN) for trabecular iris space area (TISA750) less than 0.05 mm2 (P≤0.03) in 2,360 eyes of 2,360 Chinese American Eye Study participants.

DiagnosisCross-sectionalCross-sectional studyn=2,360 eyes of 2,360 participants

Cumulative gonioscopy score (sum of gonioscopy grades) was weakly predictive of intraocular pressure (IOP) at all cutoffs (adjusted R2≤0.08) in 2,360 eyes of 2,360 Chinese American Eye Study participants.

DiagnosisCross-sectionalCross-sectional studyn=2,360 eyes of 2,360 participants

The Chinese American Eye Study (CHES) involved 2,360 participants who underwent Goldmann applanation tonometry, gonioscopy, ultrasound A-scan, and anterior segment OCT (AS-OCT) imaging, with biometric data from one eye per participant used for analysis.

MethodologyCross-sectionalCross-sectional studyn=2,360 eyes of 2,360 participants