Association Between Corneal Biomechanics and 24-hour Intraocular Pressure Variation in Untreated Glaucoma.
Wu Na, Aihemaiti Xianmuseye, Sun Xinghuai, Chen Yuhong
AI Summary
In untreated glaucoma, higher corneal deformability (less stiffness) was associated with lower 24-hour intraocular pressure variation. This suggests corneal properties may influence IOP measurement and glaucoma management.
Abstract
Précis: In patients with untreated primary open-angle glaucoma, the higher the corneal deformability, the lower the changes of 24-hour intraocular pressure variation.
Purpose
To investigate the relationship between corneal biomechanics and 24-hour intraocular pressure (IOP) variation in patients with untreated primary open-angle glaucoma (POAG).
Methods
Two hundred forty-five (245) eyes of 124 patients with POAG were included in this cross-sectional study. Each patient underwent measurement of corneal biomechanics with Corvis ST. IOP measurements were taken every 2 hours during a 24-hour period by a noncontact tonometer.
Results
The study included 70 men and 54 women. The mean age was 51.41±14.42 years. In the multivariate regression analyses, lower SP-A1 was associated with smaller values of 24-hour IOP fluctuation (difference between peak and trough IOP of 24-hour recordings), mean amplitude of intraocular pressure excursion (MAPE) and average, peak and trough IOPs of the 24-hour, diurnal and nocturnal time periods. Integrated radius was negatively correlated with average, peak and trough IOPs of both the 24-hour and diurnal time course, as well as with the trough nocturnal IOP.
Conclusions
Corneal deformability reflected by biomechanical properties measured by Corvis ST is associated with 24-hour IOP variation in untreated POAG patients. Increased corneal deformability is associated with lower 24-hour IOP changes.
Shields Classification
Key Concepts4
In patients with untreated primary open-angle glaucoma (POAG), higher corneal deformability is associated with lower changes in 24-hour intraocular pressure (IOP) variation.
In a cross-sectional study of 245 eyes of 124 patients with untreated primary open-angle glaucoma (POAG), lower SP-A1 (a corneal biomechanical parameter) was associated with smaller values of 24-hour IOP fluctuation, mean amplitude of intraocular pressure excursion (MAPE), and average, peak, and trough IOPs of the 24-hour, diurnal, and nocturnal time periods in multivariate regression analyses.
In a cross-sectional study of 245 eyes of 124 patients with untreated primary open-angle glaucoma (POAG), integrated radius (a corneal biomechanical parameter) was negatively correlated with average, peak, and trough IOPs of both the 24-hour and diurnal time course, as well as with the trough nocturnal IOP.
Corneal deformability, as reflected by biomechanical properties measured by Corvis ST, is associated with 24-hour intraocular pressure (IOP) variation in untreated primary open-angle glaucoma (POAG) patients.
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