Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage.
Kim Jeong-Ah, Kim Tae-Woo, Lee Eun Ji, Kim Joon Mo, Girard Michaël J A, Mari Jean Martial
AI Summary
This study found normal tension glaucoma eyes have significantly steeper lamina cribrosa curvature than healthy eyes, suggesting LC remodeling is key in NTG development.
Abstract
Purpose
To investigate intereye differences in lamina cribrosa (LC) morphology in normal tension glaucoma (NTG) patients with unilateral damage.
Methods
A total of 152 eyes of 76 treatment-naive NTG patients with unilateral damage from the ongoing Investigating Glaucoma Progression Study were included. Optic nerve heads were scanned using enhanced-depth spectral-domain optical coherence tomography. The magnitude of the LC curve and LC position were assessed by measuring the LC curve index (LCCI) and LC depth (LCD), respectively, at seven locations spaced equidistantly across the vertical optic disc diameter. LCCI and LCD were compared between glaucomatous and fellow healthy eyes.
Results
Eyes with NTG had larger average LCCI and LCD than contralateral healthy eyes (for both P < 0.002). The LCCI was greater in the glaucomatous eyes at all seven locations (P < 0.001). Univariate conditional logistic regression analysis showed that higher baseline intraocular pressure (P = 0.010), deeper LCD (P = 0.007), and larger LCCI (P < 0.001) were significantly associated with the presence of glaucoma. In multivariate analysis, only larger LCCI was significantly associated with the presence of glaucoma (P < 0.001).
Conclusions
Glaucomatous eyes have more steeply curved LC than fellow healthy eyes. This finding suggests that LC undergoes significant remodeling in NTG eyes.
MeSH Terms
Shields Classification
Key Concepts5
Normal tension glaucoma (NTG) eyes had a larger average lamina cribrosa curve index (LCCI) and lamina cribrosa depth (LCD) than contralateral healthy eyes (for both P < 0.002) in a study of 152 eyes of 76 treatment-naive NTG patients with unilateral damage.
In normal tension glaucoma (NTG) patients with unilateral damage, the lamina cribrosa curve index (LCCI) was greater in the glaucomatous eyes at all seven locations across the vertical optic disc diameter (P < 0.001) compared to fellow healthy eyes in a study of 152 eyes of 76 treatment-naive NTG patients.
Multivariate analysis in 76 treatment-naive normal tension glaucoma (NTG) patients with unilateral damage revealed that only a larger lamina cribrosa curve index (LCCI) was significantly associated with the presence of glaucoma (P < 0.001).
Glaucomatous eyes have more steeply curved lamina cribrosa than fellow healthy eyes, suggesting that the lamina cribrosa undergoes significant remodeling in normal tension glaucoma (NTG) eyes, based on a study of 152 eyes of 76 treatment-naive NTG patients with unilateral damage.
Univariate conditional logistic regression analysis in 76 treatment-naive normal tension glaucoma (NTG) patients with unilateral damage showed that higher baseline intraocular pressure (P = 0.010), deeper lamina cribrosa depth (P = 0.007), and larger lamina cribrosa curve index (P < 0.001) were significantly associated with the presence of glaucoma.
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