Girard Michaël J A

Shiromani Sakshi, Ferenchak Kevin, Barnett Joshua, Girard Michaël J A, Jain Nieraj

This review found vitrectomy for X-linked retinoschisis may improve foveal schisis and vision, but retinal detachment repair has lower single-surgery success. This informs assessing gene therapy outcomes requiring vitrectomy.

Liu Tingting, Wang Ya Xing, Jonas Jost B, Hoang Quan V, Girard Michaël J A, Wang Xiaofei

Gaze-induced optic nerve head deformations are greater in high myopia, increasing with axial length. This highlights biomechanical factors in glaucoma and optic neuropathies in myopic eyes.

Chiang Charis Y N, Wang Xiaofei, Gardiner Stuart K, Buist Martin, Girard Michaël J A

This study found straighter optic nerves and less globe proptosis/size (ILPP distance) correlate with thinner RGC layers, suggesting orbital biomechanics impact RGC health and may aid glaucoma risk assessment.

Tan Royston K Y, Tun Tin A, Braeu Fabian A, Perera Shamira A, Girard Michaël J A

Computational modeling showed iris crypts can help prevent angle closure by maintaining a wider angle, even with reduced iris permeability. This suggests new treatment targets for high-risk patients.

Chuangsuwanich Thanadet, Tun Tin A, Braeu Fabian A, Chong Rachel S, Wang Xiaofei, Ho Ching-Lin et al.

This study found that highly myopic glaucoma, pathologic myopia, and staphyloma eyes show greater macular curvature changes from acute IOP elevation than highly myopic or emmetropic eyes, indicating increased sensitivity to pressure.

Tan Royston K Y, Ng Gim Yew, Tun Tin A, Braeu Fabian A, Nongpiur Monisha E, Aung Tin et al.

Finite element analysis showed iris thickness, convexity, stiffness, and anterior chamber dimensions significantly influence angle narrowing during pupil dilation, guiding risk assessment for angle-closure glaucoma.

Liu Tingting, Hung Pham Tan, Wang Xiaofei, Girard Michaël J A

This study found optic nerve morphology, especially tortuosity and dural radius, significantly impacts gaze-induced optic nerve head strain, with morphological factors generally more influential than tissue stiffnesses.

Jiravarnsirikul Anuwat, Yang Hongli, Jeoung Jin Wook, Hong Seung Woo, Rezapour Jasmin, Gardiner Stuart et al.

Highly myopic eyes show more pronounced remodeling of the optic nerve's scleral flange and neural canal, particularly inferior-temporally. This finding highlights structural differences that may impact glaucoma susceptibility in myopia.

Braeu Fabian A, Chuangsuwanich Thanadet, Tun Tin A, Perera Shamira, Husain Rahat, Thiery Alexandre H et al.

AI can predict optic nerve head robustness from a single OCT scan, potentially identifying glaucoma patients at higher risk for rapid vision loss, without needing invasive biomechanical testing.

Chiang Charis Y N, Braeu Fabian A, Chuangsuwanich Thanadet, Tan Royston K Y, Chua Jacqueline, Schmetterer Leopold et al.

AI analyzed wide-field OCT scans to diagnose glaucoma, finding that combining optic nerve head and macula data significantly improved diagnostic accuracy over either alone, suggesting better clinical detection.

Tan Royston K Y, Panda Satish K, Braeu Fabian A, Muralidharan Arumugam R, Nongpiur Monisha E, Chan Anita S Y et al.

This study found porcine iris stroma is permeable and biomechanically distinct from the dilator muscle, offering insights into angle-closure glaucoma mechanisms.

Chuangsuwanich Thanadet, Tun Tin A, Braeu Fabian A, Yeoh Clarice H Y, Chong Rachel S, Wang Xiaofei et al.

This study found highly myopic glaucoma and pathologic myopia with staphyloma cause greater optic nerve head strain from IOP elevation, indicating increased biomechanical vulnerability.

Burgoyne Claude F, Wang Ya Xing, Jeoung Jin Wook, Hong Seungwoo, Gardiner Stuart, Reynaud Juan et al.

OCT showed highly myopic eyes have increased optic nerve scleral bowing and decreased choroidal thickness, especially inferiorly. This suggests bowing may indicate glaucoma susceptibility in high myopia.

Thiéry Alexandre H, Braeu Fabian, Tun Tin A, Aung Tin, Girard Michaël J A

Geometric deep learning on OCT scans diagnosed glaucoma more accurately than CNNs or RNFL thickness, potentially simplifying and improving clinical diagnosis.

Braeu Fabian A, Thiéry Alexandre H, Tun Tin A, Kadziauskiene Aiste, Barbastathis George, Aung Tin et al.

Geometric deep learning accurately diagnosed glaucoma from 3D ONH OCT scans, identifying critical hourglass-pattern features in the neuroretinal rim, offering potential for improved clinical diagnosis and prognosis.

Sreejith Kumar Ashish Jith, Chong Rachel S, Crowston Jonathan G, Chua Jacqueline, Bujor Inna, Husain Rahat et al.

Researchers found AI-generated synthetic OCT images effectively train deep learning models for glaucoma detection, performing comparably to real images, offering a solution for data scarcity and sharing.

Kim Jeong-Ah, Lee Seung Hyen, Son Dong Hwan, Kim Tae-Woo, Lee Eun Ji, Girard Michaël J A et al.

This study found topical IOP lowering in NTG patients caused detectable lamina cribrosa curvature changes in most eyes, suggesting structural response to treatment.

Panda Satish K, Tan Royston K Y, Tun Tin A, Buist Martin L, Nongpiur Monisha, Baskaran Mani et al.

This study found irises in angle-closure glaucoma are stiffer and less permeable than healthy irises, suggesting biomechanical differences contribute to the disease and could inform future management.

Kim Jeong-Ah, Lee Eun Ji, Kim Tae-Woo, Kim Hyunjoong, Girard Michaël J A, Mari Jean Martial et al.

This study found lamina cribrosa morphology differs between NAION and NTG, even with similar nerve damage. This helps distinguish these conditions and understand their unique disease mechanisms.

Lee Seung Hyen, Lee Eun Ji, Kim Joon Mo, Girard Michaël J A, Mari Jean Martial, Kim Tae-Woo

Trabeculectomy in myopic glaucoma patients significantly reduced lamina cribrosa depth, meaning it moved anteriorly. This finding suggests IOP reduction can mechanically alter the optic nerve head, potentially benefiting nerve health.

Jeoung Jin Wook, Yang Hongli, Gardiner Stuart, Wang Ya Xing, Hong Seungwoo, Fortune Brad et al.

This study found highly myopic eyes have greater optic nerve head obliqueness and ASCO/BMO offset, leading to a smaller neural canal area, which impacts glaucoma assessment.

Chuangsuwanich Thanadet, Hung Pham Tan, Wang Xiaofei, Liang Leo Hwa, Schmetterer Leopold, Boote Craig et al.

This study modeled lamina cribrosa oxygen levels, finding LC radius and perfusion pressure are key. Higher IOP slightly lowers oxygen, suggesting biomechanical and vascular factors contribute to glaucoma's optic nerve damage.

Kim Ji-Ah, Kim Tae-Woo, Lee Eun Ji, Girard Michaël J A, Mari Jean Martial

NTG eyes showed thinner, more curved lamina cribrosa than healthy/OHT eyes, which had thicker, less curved lamina. This suggests distinct structural differences in glaucoma types.

Jin Yuejiao, Wang Xiaofei, Irnadiastputri Sylvi Febriana Rachmawati, Mohan Rosmin Elsa, Aung Tin, Perera Shamira A et al.

A model showed increasing heart rate decreased ocular pulse and ONH deformation, while stiffening the lamina cribrosa. This suggests heart rate impacts ONH biomechanics, relevant for glaucoma pathology.

Lee Kyoung Min, Kim Tae-Woo, Lee Eun Ji, Girard Michaël J A, Mari Jean Martial, Weinreb Robert N

In POAG patients, lower corneal hysteresis was linked to a more curved lamina cribrosa, suggesting it reflects structural vulnerability and could aid glaucoma risk assessment.