Yang Hongli

Williams Galen, Lee Jinho, Zangirolani Gabriel, Reynaud Juan, Yang Hongli, Marsh-Armstrong Nicholas et al.

Early glaucoma causes spatially distinct retrolaminar myelin loss and laminar inflammatory/collagen changes in the ONH. This reveals molecular pathogenesis and potential neuroprotective targets.

Gardiner Stuart K, Reynaud Juan, Cull Grant, Yang Hongli, Mansberger Steven L, Fortune Brad

Studying glaucoma progression, researchers found faster disease worsening correlated with increased pulsatility in peripapillary arteries, suggesting impaired retinal vasodilation. This highlights a potential vascular biomarker for glaucoma management.

Jiravarnsirikul Anuwat, Belghith Akram, Rezapour Jasmin, Bowd Christopher, Moghimi Sasan, Jonas Jost B et al.

Diagnosing glaucoma in myopic eyes is challenging due to structural and visual field confounds, requiring careful interpretation of standard diagnostic tests for effective patient management.

Yang Hongli, Reynaud Juan, Sharpe Glen P, Jennings Dawn, Albert Cindy, Holthausen Trinity et al.

This study found pixelwise analysis of retinal nerve fiber layer (NFL) and ganglion cell layer (GCL) thickness best detects glaucoma, suggesting combined layer assessment improves diagnostic accuracy.

Yang Hongli, Cull Grant, Yang Mingrui, Wang Lin, Fortune Brad, Gardiner Stuart K

This study found glaucoma patients and suspects have higher blood pressure and arterial stiffness (faster systemic pulse waveform) than healthy controls, suggesting systemic vascular changes contribute to glaucoma.

Higgins Bethany E, Yang Hongli, Gardiner Stuart K

This study found retinal nerve fiber layer thickness and minimum rim width change concurrently in glaucoma, with no significant time lag. This suggests both are valuable, but RNFLT may be better for early assessment.

Jiravarnsirikul Anuwat, Yang Hongli, Jeoung Jin Wook, Hong Seung Woo, Rezapour Jasmin, Gardiner Stuart et al.

Highly myopic eyes show more pronounced remodeling of the optic nerve's scleral flange and neural canal, particularly inferior-temporally. This finding highlights structural differences that may impact glaucoma susceptibility in myopia.

Chaudhary Priya, Lockwood Howard, Stowell Cheri, Bushong Eric, Reynaud Juan, Yang Hongli et al.

Nonhuman primate glaucoma studies found structurally intact optic nerve axons show significant demyelination. This suggests a novel mechanism of nerve damage in early/moderate glaucoma, impacting vision beyond axon loss.

Hong Seungwoo, Yang Hongli, Gardiner Stuart K, Luo Haomin, Sharpe Glen P, Caprioli Joseph et al.

This study found that optic nerve head remodeling in non-highly myopic eyes correlates with exposed scleral flange and thin choroid, suggesting implications for glaucoma risk, especially in high myopia.

Chaudhary Priya, Stowell Cheri, Reynaud Juan, Gardiner Stuart K, Yang Hongli, Williams Galen et al.

This NHP study found early glaucoma causes optic nerve myelin loss and increased microglial activity, suggesting these changes are crucial for understanding and treating early glaucoma.

Lowry Eugene A, Mansberger Steven L, Gardiner Stuart K, Yang Hongli, Sanchez Facundo, Reynaud Juan et al.

This study found optic nerve head prelaminar schisis is more common and severe in glaucoma/suspect eyes, indicating glaucomatous damage and potentially affecting OCT measurement accuracy.

Zhang Qi, Lin Cai Xia, Yang Hongli, Chen Jian Dong, Jonas Jost B, Wang Ya Xing

Short-term IOP elevation initially widened the central retinal vein, but higher IOP compressed it, while arteries were unaffected. This suggests differential vascular response to IOP changes in glaucoma.

Jeoung Jin Wook, Yang Hongli, Gardiner Stuart, Wang Ya Xing, Hong Seungwoo, Fortune Brad et al.

This study found highly myopic eyes have greater optic nerve head obliqueness and ASCO/BMO offset, leading to a smaller neural canal area, which impacts glaucoma assessment.

Wang Ya Xing, Yang Hongli, Luo Haomin, Hong Seung Woo, Gardiner Stuart K, Jeoung Jin Wook et al.

OCT showed peripapillary scleral bowing increases with age and links to thinner choroids in healthy eyes. This provides a baseline for glaucoma and myopia research.

Yang Hongli, Luo Haomin, Hardin Christy, Wang Yaxing, Jeoung Jin Wook, Albert Cindy et al.

This study found that combining topographically aligned OCT rim width and nerve fiber layer measurements accurately detects glaucoma, offering high diagnostic precision for identifying structural damage.

Wang Ya Xing, Zhang Qi, Yang Hongli, Chen Jian Dong, Wang Ningli, Jonas Jost B

Acute IOP elevation causes lamina cribrosa pores to move laterally, more so with higher IOP rise and deeper optic cups. This movement may contribute to glaucomatous nerve damage.

Hong Seungwoo, Yang Hongli, Gardiner Stuart K, Luo Haomin, Hardin Christy, Sharpe Glen P et al.

This study found the optic nerve's narrowest point (NCMCA) is smaller than its openings and correlates best with RNFLT, whose distribution is influenced by neural canal direction, offering insights into glaucoma risk.

Yang Hongli, Luo Haomin, Gardiner Stuart K, Hardin Christy, Sharpe Glen P, Caprioli Joseph et al.

This study found peripapillary choroidal thickness (PCT) in healthy eyes is thinnest inferior-temporally and decreases with age, axial length, and European descent, with age being the strongest factor, especially in thinner sectors.

Hong Seung Woo, Koenigsman Helen, Yang Hongli, Ren Ruojin, Reynaud Juan, Kinast Robert M et al.

Glaucoma specialists often miss optic nerve rim thinning, particularly in nasal sectors where it's common, highlighting a diagnostic gap between clinical exam and OCT findings.

Hong Seung Woo, Koenigsman Helen, Ren Ruojin, Yang Hongli, Gardiner Stuart K, Reynaud Juan et al.

Glaucoma specialists showed frequent, substantial disagreement in marking optic disc features, even for suspicious rim thinning, highlighting the need for more objective assessment methods.

Luo Haomin, Yang Hongli, Gardiner Stuart K, Hardin Christy, Sharpe Glen P, Caprioli Joseph et al.

This study found central lamina cribrosa depth in healthy eyes varies with age, sex, and eye size. African descent eyes had deeper central lamina, but the clinical importance of these small differences is still unknown.

Girkin Christopher A, Fazio Massimo A, Yang Hongli, Reynaud Juan, Burgoyne Claude F, Smith Brandon et al.

This study found African-descended individuals have thinner lamina cribrosa and sclera, with age-related thickening/deepening, suggesting structural differences may explain their higher glaucoma risk.

Yang Hongli, Reynaud Juan, Lockwood Howard, Williams Galen, Hardin Christy, Reyes Luke et al.

This monkey study found glaucoma causes optic nerve head connective tissue deformation and remodeling, driven by cellular mechanobiology, leading to nerve damage. This highlights connective tissue as a therapeutic target.

Ivers Kevin M, Yang Hongli, Gardiner Stuart K, Qin Lirong, Reyes Luke, Fortune Brad et al.

Monkey glaucoma eyes showed increased optic nerve head deformation with IOP changes, indicating hypercompliance. This suggests mechanical vulnerability at early disease stages.

Fortune Brad, Hardin Christy, Reynaud Juan, Cull Grant, Yang Hongli, Wang Lin et al.

This study found peripapillary RNFLT correlates best with actual axon loss in experimental glaucoma, suggesting it's a more reliable SDOCT measure than optic nerve head rim parameters for monitoring disease.