Williams Galen

Williams Galen, Lee Jinho, Zangirolani Gabriel, Reynaud Juan, Yang Hongli, Marsh-Armstrong Nicholas et al.

Early glaucoma causes spatially distinct retrolaminar myelin loss and laminar inflammatory/collagen changes in the ONH. This reveals molecular pathogenesis and potential neuroprotective targets.

Chaudhary Priya, Stowell Cheri, Reynaud Juan, Gardiner Stuart K, Yang Hongli, Williams Galen et al.

This NHP study found early glaucoma causes optic nerve myelin loss and increased microglial activity, suggesting these changes are crucial for understanding and treating early glaucoma.

Yang Hongli, Reynaud Juan, Lockwood Howard, Williams Galen, Hardin Christy, Reyes Luke et al.

This monkey study found glaucoma causes optic nerve head connective tissue deformation and remodeling, driven by cellular mechanobiology, leading to nerve damage. This highlights connective tissue as a therapeutic target.

Reynaud Juan, Lockwood Howard, Gardiner Stuart K, Williams Galen, Yang Hongli, Burgoyne Claude F

Monkey early glaucoma increases lamina cribrosa pore diameter, connective tissue, and volume. This structural remodeling, though variable, may indicate early disease changes, aiding diagnosis and monitoring.

Yang Hongli, Ren Ruojin, Lockwood Howard, Williams Galen, Libertiaux Vincent, Downs Crawford et al.

Monkey experimental glaucoma caused five distinct optic nerve head connective tissue changes: posterior deformation, laminar thickening/thinning, scleral canal expansion, laminar insertion migration, and peripapillary scleral bowing, providing targets for staging optic neuropathy.

Yang Hongli, Williams Galen, Downs J Crawford, Sigal Ian A, Roberts Michael D, Thompson Hilary et al.

This monkey study found early glaucoma causes significant posterior migration of the lamina cribrosa, increasing its length. This outward movement contributes to early optic nerve cupping, a key sign of glaucomatous damage.