Roberts Michael D

Sigal Ian A, Yang Hongli, Roberts Michael D, Grimm Jonathan L, Burgoyne Claude F, Demirel Shaban et al.

This study found the association between IOP-induced lamina cribrosa deformation and scleral canal expansion varies significantly with individual eye tissue properties, impacting clinical interpretation of these glaucoma markers.

Yang Hongli, Williams Galen, Downs J Crawford, Sigal Ian A, Roberts Michael D, Thompson Hilary et al.

This monkey study found early glaucoma causes significant posterior migration of the lamina cribrosa, increasing its length. This outward movement contributes to early optic nerve cupping, a key sign of glaucomatous damage.

Yang Hongli, Thompson Hilary, Roberts Michael D, Sigal Ian A, Downs J Crawford, Burgoyne Claude F

This study found early glaucoma in monkeys causes optic nerve head deformation, including posterior bowing and canal expansion, potentially localized to specific quadrants, but hypercompliance was not consistently observed.

Roberts Michael D, Sigal Ian A, Liang Yi, Burgoyne Claude F, Downs J Crawford

This study found early glaucoma alters optic nerve head biomechanics, making its tissues more compliant and reducing stress under pressure, suggesting remodeling impacts disease progression.

Yang Hongli, Downs J Crawford, Sigal Ian A, Roberts Michael D, Thompson Hilary, Burgoyne Claude F

Acute IOP elevation in monkeys caused regional optic nerve head connective tissue thinning and deformation, suggesting mechanical stress on structures critical for glaucoma pathogenesis.

Roberts Michael D, Liang Yi, Sigal Ian A, Grimm Jonathan, Reynaud Juan, Bellezza Anthony et al.

Monkey eye models showed local lamina cribrosa stress and strain correlate with connective tissue volume fraction, suggesting this microarchitecture predicts glaucoma damage sites.

Roberts Michael D, Grau Vicente, Grimm Jonathan, Reynaud Juan, Bellezza Anthony J, Burgoyne Claude F et al.

Early glaucoma remodels the lamina cribrosa, significantly increasing connective tissue volume and beam number without much change in overall density, indicating structural alterations relevant to disease progression.