Cull Grant

Arrashoud Arwa, Reynaud Juan, Dunn Michaela, Cull Grant, Gardiner Stuart K, Fortune Brad

Novel OCTA extravascular motion (EVM) signals, representing pulsatile tissue displacement, are more prevalent in experimental glaucoma eyes and at higher IOP. This EVM may be a novel biomarker for altered biomechanics and vascular health in glaucoma.

Dunn Michaela, Cull Grant, Reynaud Juan, Gardiner Stuart K, Di Polo Adriana, Fortune Brad

RNFL microvascular compromise significantly precedes neuroretinal tissue loss in glaucoma. This highlights early vascular dysfunction, suggesting vascular-targeted therapies may be crucial for disease management.

Gardiner Stuart K, Reynaud Juan, Cull Grant, Yang Hongli, Mansberger Steven L, Fortune Brad

Studying glaucoma progression, researchers found faster disease worsening correlated with increased pulsatility in peripapillary arteries, suggesting impaired retinal vasodilation. This highlights a potential vascular biomarker for glaucoma management.

Yang Hongli, Cull Grant, Yang Mingrui, Wang Lin, Fortune Brad, Gardiner Stuart K

This study found glaucoma patients and suspects have higher blood pressure and arterial stiffness (faster systemic pulse waveform) than healthy controls, suggesting systemic vascular changes contribute to glaucoma.

Higgins Bethany E, Cull Grant, Gardiner Stuart K

This glaucoma study found visual field changes (MD) precede optic nerve blood flow changes, which may then precede retinal nerve fiber thinning (RNFLT), suggesting a potential disease progression sequence.

Dunn Michaela, Cull Grant, Reynaud Juan, Jennings Dawn, Holthausen Trinity, Di Polo Adriana et al.

This study found the photopic negative response (PhNR) to a brief red/blue flash is best for detecting early glaucoma functional loss. Longer flashes offer no additional clinical benefit.

Gardiner Stuart K, Cull Grant, Fortune Brad

Retinal vascular resistance, indicating stiffer vessels, predicted faster functional loss in glaucoma suspects, suggesting it could identify those at higher risk for progression before significant damage occurs.

Gardiner Stuart K, Cull Grant, Fortune Brad, Wang Lin

This study found optic nerve head capillary blood flow was paradoxically increased in early glaucoma suspects, then decreased with functional loss but remained above healthy controls, suggesting complex vascular changes in human glaucoma.

Li Hui, Bui Bang V, Cull Grant, Wang Fang, Wang Lin

Retinal glial cells modulate basal venous diameter and pressure-induced vascular responses, suggesting their role in regulating retinal blood flow in glaucoma.

Fortune Brad, Hardin Christy, Reynaud Juan, Cull Grant, Yang Hongli, Wang Lin et al.

This study found peripapillary RNFLT correlates best with actual axon loss in experimental glaucoma, suggesting it's a more reliable SDOCT measure than optic nerve head rim parameters for monitoring disease.

Ing Eliesa, Ivers Kevin M, Yang Hongli, Gardiner Stuart K, Reynaud Juan, Cull Grant et al.

Monkey optic nerve transection showed cupping results from prelaminar tissue thinning, not posterior laminar deformation. This clarifies the mechanical basis of early optic nerve head changes in glaucoma.

Wilsey Laura J, Reynaud Juan, Cull Grant, Burgoyne Claude F, Fortune Brad

This study found experimental glaucoma in primates causes specific inner retinal (ganglion cell) loss, correlating with functional deficits, with outer retinal changes likely secondary, improving glaucoma monitoring.

Told Reinhard, Wang Lin, Cull Grant, Thompson Simon J, Burgoyne Claude F, Aschinger Gerold C et al.

Doppler-OCT accurately measures total retinal blood flow, correlating well with the microsphere method and detecting flow changes after optic nerve damage, showing promise for early disease detection.

Cull Grant, Told Reinhard, Burgoyne Claude F, Thompson Simon, Fortune Brad, Wang Lin

Optic nerve degeneration directly causes decreased optic nerve head blood flow, suggesting vascular compromise is a consequence of nerve damage, not solely a primary cause in glaucoma.

Fortune Brad, Cull Grant, Reynaud Juan, Wang Lin, Burgoyne Claude F

In experimental glaucoma, retinal nerve fiber layer (RNFL) retardance and retinal ganglion cell function decline *before* RNFL thickness or optic nerve axon loss, suggesting they are early damage biomarkers.

Fortune Brad, Burgoyne Claude F, Cull Grant, Reynaud Juan, Wang Lin

This study found peripapillary RNFL retardance changes occur earlier and more frequently than RNFL thickness changes in experimental glaucoma, suggesting it's a more sensitive, earlier biomarker for glaucoma damage.

Cull Grant, Burgoyne Claude F, Fortune Brad, Wang Lin

This study found that optic nerve head blood flow in experimental glaucoma initially increases, then declines linearly with nerve damage, suggesting a two-phase hemodynamic response relevant for early detection.

Piper Chelsea, Fortune Brad, Cull Grant, Cioffi George A, Wang Lin

Monkeys with optic atrophy showed significantly reduced optic nerve blood flow and impaired autoregulation, correlating with structural damage. This suggests vascular compromise contributes to optic nerve damage.

Reynaud Juan, Cull Grant, Wang Lin, Fortune Brad, Gardiner Stuart, Burgoyne Claude F et al.

This study developed an automated method for counting optic nerve axons, finding it accurately correlated with manual counts in primate glaucoma models. This provides a reliable tool for objectively assessing glaucoma-related nerve damage.

Liang Yi, Downs J Crawford, Fortune Brad, Cull Grant, Cioffi George A, Wang Lin

This study found low systemic blood pressure impairs optic nerve head blood flow autoregulation during IOP changes in monkeys. Maintaining normal blood pressure is crucial for glaucoma patients.

Fortune Brad, Wang Lin, Cull Grant, Cioffi George A

Intravitreal colchicine in monkeys decreased retinal nerve fiber layer (RNFL) birefringence but not thickness, suggesting this discrepancy can indicate axonal degeneration.

Fortune Brad, Wang Lin, Bui Bang V, Cull Grant, Dong Jin, Cioffi George A

Studying macaque ganglion cell loss, researchers found slowed-sequence mfERG, particularly high-frequency components, most effectively detects local damage, highlighting its potential for early glaucoma diagnosis.

Wang Lin, Dong Jin, Cull Grant, Fortune Brad, Cioffi George A

This study found human and primate retinal ganglion cell axons are predominantly varicose, rich in mitochondria, suggesting these swellings are functional sites for high-energy demands and signal transmission in glaucoma.

Wang Lin, Cioffi George A, Cull Grant, Dong Jin, Fortune Brad

This study found increased density and altered morphology of activated retinal glial cells (astrocytes) in human glaucoma, particularly around blood vessels, suggesting their role in disease progression.