Bui Bang V

Ganearachchi Sera N, Zhao Da, Wong Vickie H Y, Lee Pei Ying, Afiat Brianna C, Nguyen Christine T O et al.

This rat study found that reducing optic nerve sheath pressure worsened optic nerve damage from elevated eye pressure, suggesting CSF pressure is crucial in glaucoma.

Nguyen Bao N, Cleary Jon O, Glarin Rebecca, Kolbe Scott C, Moffat Bradford A, Ordidge Roger J et al.

7T MRI showed myopes have smaller retrobulbar optic nerves and subarachnoid spaces than emmetropes. This tool can assess optic nerve morphology behind the eye, relevant for glaucoma and myopia-related conditions.

Zhao Da, He Zheng, Wang Lin, Fortune Brad, Lim Jeremiah K H, Wong Vickie H Y et al.

This study found intermediate and deep retinal vessels in rats are more resistant to mild IOP elevation than superficial vessels, but all layers are affected by high IOP.

Zhao Da, Wong Vickie H Y, Nguyen Christine T O, Jobling Andrew I, Fletcher Erica L, Vingrys Algis J et al.

This mouse study found that retinal ganglion cell dysfunction from chronic IOP elevation was reversible after 8 weeks but irreversible after 12 weeks, highlighting the importance of early glaucoma intervention.

Bui Bang V

Li Hui, Bui Bang V, Cull Grant, Wang Fang, Wang Lin

Retinal glial cells modulate basal venous diameter and pressure-induced vascular responses, suggesting their role in regulating retinal blood flow in glaucoma.

Liu Hsin-Hua, Bui Bang V, Nguyen Christine T O, Kezic Jelena M, Vingrys Algis J, He Zheng

A rat model of chronic ocular hypertension using a circumlimbal suture reliably induced mild, sustained high eye pressure, causing preferential ganglion cell dysfunction and retinal nerve fiber layer thinning, useful for glaucoma research.

Nguyen Christine T O, Vingrys Algis J, Bui Bang V

Studying rats, ω-3 deficiency and high eye pressure independently harmed retinal ganglion cells, but combined, they caused significantly worse damage, suggesting ω-3 protects against glaucoma-related dysfunction.

Wong Vickie H Y, Vingrys Algis J, Jobling Andrew I, Bui Bang V

Diabetic rats showed increased retinal vulnerability and impaired ocular blood flow autoregulation under high IOP, linked to reduced eNOS upregulation, suggesting diabetes exacerbates glaucoma risk.

Kohzaki Kenichi, Vingrys Algis J, Armitage James A, Bui Bang V

Diabetic rats showed greater inner retinal damage (pSTR reduction) after acute intraocular pressure elevation than non-diabetic rats, suggesting hyperglycemia increases glaucoma susceptibility.

Kohzaki Kenichi, Vingrys Algis J, Bui Bang V

This rat study found early, significant impairment of inner retinal ganglion cell function (pSTR) in diabetes, suggesting early neuronal damage in diabetic retinopathy.

Nguyen Christine T O, Vingrys Algis J, Bui Bang V

Omega-3 deficiency primarily impairs inner retinal/ganglion cell function, causing signal delays and amplitude decreases. Supplementation may improve ganglion cell health, relevant for glaucoma.

He Zheng, Bui Bang V, Vingrys Algis J

Repeated high IOP insults cumulatively damage inner retinal function in rats. Surprisingly, fluctuating IOP challenges showed faster retinal recovery than constant high IOP, suggesting variation itself isn't detrimental.

Nguyen Christine T O, Bui Bang V, Sinclair Andrew J, Vingrys Algis J

Dietary omega-3 fatty acids in rats decreased age-related intraocular pressure by improving aqueous outflow. This suggests diet could be a modifiable factor for glaucoma management.

He Zheng, Bui Bang V, Vingrys Algis J

Acute IOP elevation in rats showed inner retinal (ganglion cell) function recovers slowest. Peak IOP, not just duration, primarily determines functional loss and recovery, impacting glaucoma management.

Fortune Brad, Wang Lin, Bui Bang V, Burgoyne Claude F, Cioffi George A

Idiopathic bilateral optic atrophy in macaques causes optic nerve damage, retinal ganglion cell loss, and specific functional deficits, warranting caution when using these animals in ophthalmic research.

Bui Bang V, Edmunds Beth, Cioffi George A, Fortune Brad

This study found that acute IOP elevation in rats causes functional changes progressing from inner to outer retina, with ganglion cell-related responses (nSTR, photopic OPs) most sensitive to moderate IOP (30-50 mmHg). This highlights the need to maintain IOP below 50 mmHg in experimental glaucoma models to avoid non-specific damage.

Fortune Brad, Bui Bang V, Morrison John C, Johnson Elaine C, Dong Jin, Cepurna William O et al.

This rat study found mild, chronic IOP elevation causes selective retinal ganglion cell functional loss before structural damage, suggesting early RGC vulnerability in glaucoma.

Fortune Brad, Wang Lin, Bui Bang V, Cull Grant, Dong Jin, Cioffi George A

Studying macaque ganglion cell loss, researchers found slowed-sequence mfERG, particularly high-frequency components, most effectively detects local damage, highlighting its potential for early glaucoma diagnosis.