Sharpe Glen P

Matsuo Masato, Sharpe Glen P, Hutchison Donna M, Shuba Lesya M, Nicolela Marcelo T, Chauhan Balwantray C

This study found normal aging causes about half of the retinal nerve fiber layer thinning observed in treated glaucoma patients, helping distinguish age-related changes from disease progression.

Tomita Ryo, Smith Corey A, Dyachok Oksana M, Sharpe Glen P, Rafuse Paul E, Shuba Lesya M et al.

Macular ganglion cell layer thinning precedes and is more detectable than macular perfusion density changes in early glaucoma, suggesting GCL thickness is a better early progression marker.

Yang Hongli, Reynaud Juan, Sharpe Glen P, Jennings Dawn, Albert Cindy, Holthausen Trinity et al.

This study found pixelwise analysis of retinal nerve fiber layer (NFL) and ganglion cell layer (GCL) thickness best detects glaucoma, suggesting combined layer assessment improves diagnostic accuracy.

Smith Corey A, Josey Vanessa L, West Michael E, Dyachok Oksana M, Sharpe Glen P, Vianna Jayme R et al.

Longitudinal OCT-A showed perfusion density increased over time in glaucoma patients and controls, even accounting for scan quality, suggesting a learning effect. This impacts interpreting long-term OCT-A results.

Darwich Rami, Jarrar Faisal, Syed Mustafa, Sharpe Glen P, Chauhan Balwantray C

This study compared deep optic nerve head structure visibility in glaucoma patients using SD-OCT and SS-OCT. Both modalities were statistically equivalent, but SS-OCT tended to show better visualization, aiding early glaucoma detection.

Tomita Ryo, Rawlyk Brooklyn, Sharpe Glen P, Hutchison Donna M, Shuba Lesya M, Nicolela Marcelo T et al.

This study found optic nerve rim and nerve fiber layer thinning occurs at all glaucoma stages, but RNFLT shows an earlier "floor effect" than MRW, suggesting different tissue remodeling and earlier measurement limitations.

Hong Seungwoo, Yang Hongli, Gardiner Stuart K, Luo Haomin, Sharpe Glen P, Caprioli Joseph et al.

This study found that optic nerve head remodeling in non-highly myopic eyes correlates with exposed scleral flange and thin choroid, suggesting implications for glaucoma risk, especially in high myopia.

Quach Jack, Sharpe Glen P, Demirel Shaban, Girkin Christopher A, Mardin Christian Y, Scheuerle Alexander F et al.

This study found minimal right-left asymmetry in retinal blood vessels, and this asymmetry doesn't explain the observed differences in retinal nerve fiber layer thickness between eyes.

Kim Yong Woo, Sharpe Glen P, Hutchison Donna M, Rafuse Paul E, Shuba Lesya M, Nicolela Marcelo T et al.

This study found glaucoma severity didn't influence OCT thickness change rates, but macular GCL thickness best distinguished glaucoma progression from healthy aging, suggesting its utility in monitoring.

West Michael E, Sharpe Glen P, Hutchison Donna M, Rafuse Paul E, Shuba Lesya M, Nicolela Marcelo T et al.

This study found 10-2 visual fields offered little additional detection of central damage in early glaucoma compared to 24-2, suggesting 10-2 is best reserved for monitoring specific high-risk patients.

Hirasawa Kazunori, Smith Corey A, West Michael E, Sharpe Glen P, Shuba Lesya M, Rafuse Paul E et al.

This study found that under one-third of early glaucoma patients had greater macular perfusion loss than ganglion cell layer loss, suggesting signal quality may influence apparent perfusion deficits.

Wang Ya Xing, Yang Hongli, Luo Haomin, Hong Seung Woo, Gardiner Stuart K, Jeoung Jin Wook et al.

OCT showed peripapillary scleral bowing increases with age and links to thinner choroids in healthy eyes. This provides a baseline for glaucoma and myopia research.

Smith Corey A, West Michael E, Sharpe Glen P, Hutchison Donna M, Shuba Lesya M, Rafuse Paul E et al.

This study found a novel asymmetry index (PAI) for macular OCT-A better correlated with visual field loss than perfusion density alone in glaucoma, but its diagnostic accuracy was still inferior to ganglion cell layer thickness.

Yang Hongli, Luo Haomin, Hardin Christy, Wang Yaxing, Jeoung Jin Wook, Albert Cindy et al.

This study found that combining topographically aligned OCT rim width and nerve fiber layer measurements accurately detects glaucoma, offering high diagnostic precision for identifying structural damage.

Chauhan Balwantray C, Vianna Jayme R, Sharpe Glen P, Demirel Shaban, Girkin Christopher A, Mardin Christian Y et al.

This study found macular ganglion cell layer (GCL) thinning with age was twice as strongly associated than neuroretinal rim or RNFL loss, suggesting GCL thickness may better track glaucoma progression.

Torres Lucas A, Sharpe Glen P, Hutchison Donna M, Zangalli Camila S, Burk Reinhard O, Reis Alexandre S C et al.

This study found RNFLT glaucoma diagnostic sensitivity was higher in eyes with larger BMOA, but MRW sensitivity was BMOA-independent, suggesting BMOA may influence RNFLT interpretation.

Hong Seungwoo, Yang Hongli, Gardiner Stuart K, Luo Haomin, Hardin Christy, Sharpe Glen P et al.

This study found the optic nerve's narrowest point (NCMCA) is smaller than its openings and correlates best with RNFLT, whose distribution is influenced by neural canal direction, offering insights into glaucoma risk.

Yang Hongli, Luo Haomin, Gardiner Stuart K, Hardin Christy, Sharpe Glen P, Caprioli Joseph et al.

This study found peripapillary choroidal thickness (PCT) in healthy eyes is thinnest inferior-temporally and decreases with age, axial length, and European descent, with age being the strongest factor, especially in thinner sectors.

Torres Lucas A, Jarrar Faisal, Sharpe Glen P, Hutchison Donna M, Ferracioli-Oda Eduardo, Hatanaka Marcelo et al.

Excluding protruded retinal layers from OCT optic nerve head rim width measurements did not improve glaucoma diagnostic accuracy or correlation with RNFL thickness, indicating no clinical utility.

Vianna Jayme R, Butty Ziad, Torres Lucas A, Sharpe Glen P, Hutchison Donna M, Shuba Lesya M et al.

This study found glaucoma primarily thins inner retinal layers (nerve fiber, ganglion cell, inner plexiform), not outer layers, in eyes with hemifield defects. This reinforces that glaucoma is an inner retina disease.

Torres Lucas A, Vianna Jayme R, Jarrar Faisal, Sharpe Glen P, Araie Makoto, Caprioli Joseph et al.

This study found that non-nerve fiber retinal layers (PRL) are common in OCT neuroretinal rim measurements of healthy eyes, especially temporally and with racial differences, impacting glaucoma assessment.

Luo Haomin, Yang Hongli, Gardiner Stuart K, Hardin Christy, Sharpe Glen P, Caprioli Joseph et al.

This study found central lamina cribrosa depth in healthy eyes varies with age, sex, and eye size. African descent eyes had deeper central lamina, but the clinical importance of these small differences is still unknown.

Loureiro Mónica M, Vianna Jayme R, Danthurebandara Vishva M, Sharpe Glen P, Hutchison Donna M, Nicolela Marcelo T et al.

This study found SS-OCT visualized a larger area of the anterior lamina cribrosa compared to SD-OCT, while other deep ONH structures were comparably visible, offering potential clinical advantages for glaucoma assessment.

Vianna Jayme R, Lanoe Victoria R, Quach Jack, Sharpe Glen P, Hutchison Donna M, Belliveau Anne C et al.

This study found that measuring lamina cribrosa depth from the anterior sclera, not Bruch's membrane, reduces choroidal thickness influence. Lamina depth changes occur as frequently as neuroretinal changes in glaucoma.

Sharpe Glen P, Danthurebandara Vishva M, Vianna Jayme R, Alotaibi Noor, Hutchison Donna M, Belliveau Anne C et al.

This study found optic disc hemorrhages (ODHs) occurred twice as often with laminar disinsertions in glaucoma patients. However, individual ODHs rarely spatially matched a disinsertion, suggesting a complex relationship.