Weinreb Robert N

Girkin Christopher A, Walker Evan, Gardiner Stuart K, Hallaj Shahin, Murillo Karla, Jiravarnsirikul Anuwat et al.

Progressive posterior lamina cribrosa remodeling predicts faster visual field progression in glaucoma. This structural-functional link is modulated by age, CCT, and IOP, suggesting varying biomechanical responses to glaucomatous stress.

Suh Min Hee, Weinreb Robert N, Hallaj Shahin, Zangwill Linda M

Optic disc microvasculature reduction is strongly associated with visual field progression in all stages of glaucoma. This suggests OCTA can help detect glaucoma worsening, even in advanced cases.

Soltani Ghazaleh, Nishida Takashi, Moghimi Sasan, Micheletti Eleonora, Hashemi Seyedehmelika, de Oliveira Pereira Amelia et al.

In glaucoma suspects, microvascular dropout and β-zone PPA progression were independently linked to optic disc structural progression, highlighting these as early markers for timely intervention.

Hong Alexander T, Lin Forest, Baxter Sally, Weinreb Robert N

Tirzepatide significantly reduced primary open-angle glaucoma, ocular hypertension, and glaucoma treatment risk in type 2 diabetes patients. This suggests a potential neuroprotective or pressure-lowering benefit, offering a novel therapeutic avenue for glaucoma management.

Torbey Julien, Weinreb Robert N, Rao Harsha L, Mansouri Kaweh

Five 18-hour IOP measurements characterize 24-hour rhythm, showing early morning peaks. This supports strategic home monitoring for comprehensive IOP fluctuation assessment, improving glaucoma management beyond clinic visits.

Hallaj Shahin, Boland Michael V, Halfpenny William, Myers Jonathan S, Weinreb Robert N, Zangwill Linda M et al.

PyOPV parses diverse ophthalmic visual field DICOM data into research formats, despite significant vendor tag variability (17-51% missing). This enables scalable integration for large-scale glaucoma research, overcoming interoperability challenges.

Huang Alex S, Garner Mary Anne, Clark Mark E, Rhodes Lindsay A, Kallab Martin, Zhang Hao F et al.

Cholinergic stimulation improved aqueous humor outflow in specific, low-flow regions of human eyes, suggesting potential for targeted glaucoma treatments.

Gunasegaran Gopikasree, Moghimi Sasan, Nishida Takashi, Liebmann Jeffrey M, Fazio Massimo A, Girkin Christopher A et al.

This study found central visual field progression identified more fast progressors across all glaucoma stages than global measures, highlighting the need to monitor central vision closely.

Nishida Takashi, Weinreb Robert N, Walker Evan, Girkin Christopher A, Fazio Massimo A, Liebmann Jeffrey M et al.

This study compared visual field progression methods in glaucoma patients with central defects, finding 10-2 VF tests detected more central progression, highlighting 24-2 VF alone may underestimate it.

Wu Jo-Hsuan, Nishida Takashi, Moghimi Sasan, Walker Evan, Zangwill Linda M, Weinreb Robert N

This study found no racial difference in glaucoma progression detection time using OCT/OCTA. However, OCTA detected progression faster than OCT in both African and European descendants, suggesting its potential to enhance monitoring.

Akarapimand Patrick, Hallaj Shahin, Weinreb Robert N, Baxter Sally L

Fitbit-measured physical activity showed no definitive independent association with primary open-angle glaucoma diagnosis after adjustment. This suggests physical activity may not be a significant independent factor in POAG.

Suh Min Hee, Weinreb Robert N, Walker Evan, Zangwill Linda M

In highly myopic glaucoma, progressive optic disc vessel density reduction, not RNFL thinning, predicted visual field progression. Monitoring microvasculature may better detect progression in these patients.

Pham Vincent Q, Nishida Takashi, Moghimi Sasan, Alam Naimul, Girkin Christopher A, Fazio Massimo A et al.

Initial OCT-measured cpRNFL loss rates predict future glaucoma progression, with faster early loss indicating higher risk. This helps clinicians predict disease course and guide patient management.

Belghith Akram, Bowd Christopher, Weinreb Robert N, Jalili Jalil, Christopher Mark, Zangwill Linda M

3D deep learning models accurately detect glaucoma, outperforming GCIPL thickness. Cross-domain models, using synthetic data, perform similarly, suggesting broader applicability across different OCT devices.

Soltani Ghazaleh, Nishida Takashi, Moghimi Sasan, Tran Elaine, Yamane Maya, Girkin Christopher et al.

This study found optic nerve head prelaminar schisis, especially severe forms, is linked to faster visual field loss in glaucoma, suggesting it's a biomarker for progression risk.

Huang Alex S, Jalili Jalil, Walker Evan, Weinreb Robert N, Laurie Steven S, Macias Brandon R et al.

AI models predicted Spaceflight Associated Neuro-Ocular Syndrome (SANS) from pre-flight OCT scans with moderate-to-high accuracy, suggesting early detection is possible and supporting bedrest as a SANS model.

Micheletti Eleonora, Rao Harsha, Weinreb Robert N, Mansouri Kaweh

An implantable IOP sensor's peak IOP and fluctuations correlated with glaucoma progression (RNFL thinning), unlike single office measurements. This suggests continuous monitoring can better predict disease worsening.

Gunasegaran Gopikasree, Moghimi Sasan, Walker Evan, Nishida Takashi, Liebmann Jeffrey M, Fazio Massimo A et al.

This study found central visual field progression impacts glaucoma patients' quality of life more than global progression, suggesting current assessments may underestimate patient-centered outcomes.

Mansouri Kaweh, Rao Harsha Laxmana, Weinreb Robert N

This study found BB-PGA combinations significantly reduce 24-hour IOP and its fluctuations more than BBs or BB-CAIs, highlighting their superior efficacy for glaucoma management.

Seo Je Hyun, Nishida Takashi, Moghimi Sasan, Wu Jo-Hsuan, Fazio Massimo A, Girkin Christopher A et al.

This study found higher physical activity levels independently slowed visual field loss in glaucoma patients, suggesting exercise may protect against disease progression.

Meller Leo L T, Kashaf Michael Saheb, Sambo Angel, Cizmic Julian, Chen Jeffrey, Moghimi Sasan et al.

Only half of registered glaucoma trials are published, often with significant delays, suggesting potential bias in the disseminated glaucoma research.

Wu Jo-Hsuan, Moghimi Sasan, Nishida Takashi, Adelpour Mohsen, Kamalipour Alireza, Gunasegaran Gopikasree et al.

This study found optic nerve head microvasculature loss occurs earlier and correlates better with visual field damage than macular loss in glaucoma, suggesting OCTA can monitor early disease.

Sit Arthur J, Aihara Makoto, Khawaja Anthony P, Lin Shan C, Mansouri Kaweh, Miki Atsuya et al.

An expert group found lowering episcleral venous pressure (EVP), even modestly, may benefit glaucoma patients, especially those with low intraocular pressure or normal-tension glaucoma, offering individualized treatment.

Vasu Pranav, Dorairaj Emily A, Weinreb Robert N, Huang Alex S, Dorairaj Syril K

In non-diabetic obese patients, GLP-1RAs significantly reduced the risk of primary open-angle glaucoma and ocular hypertension compared to other weight loss medications, suggesting a potential protective effect for eye health.

Suh Min Hee, Weinreb Robert N, Walker Evan, Zangwill Linda M

This study found optic disc microvasculature reduction is strongly linked to visual field progression in glaucoma, suggesting deep optic nerve circulation plays a key role in disease worsening.