Huang Alex S

Lee Kyunghee, Park Seungchan, Tantisattamo Ekamol, Ryu Soorack, Yu Sung, Lim Hyejin et al.

This study found intraocular pressure (IOP) transiently rises during hemodialysis, especially with higher pre-dialysis osmolality and in phakic eyes. This highlights the need for ophthalmic monitoring in high-risk dialysis patients.

Kallab Martin, Vieboeck Isabella, Panahi Parsa, Mansouri Kaweh, Bolz Matthias, Huang Alex S et al.

Excimer laser trabeculostomy significantly improved aqueous humor outflow, even beyond the treatment site, suggesting potential for enhanced glaucoma treatment.

Huang Alex S, Garner Mary Anne, Clark Mark E, Rhodes Lindsay A, Kallab Martin, Zhang Hao F et al.

Cholinergic stimulation improved aqueous humor outflow in specific, low-flow regions of human eyes, suggesting potential for targeted glaucoma treatments.

Kallab Martin, Huang Alex S, Bolz Matthias, Strohmaier Clemens A

This review found AS-OCT/AS-OCTA shows promise for assessing glaucoma bleb function after surgery, but inconsistent study methods currently limit its routine clinical application.

Huang Alex S, Jalili Jalil, Walker Evan, Weinreb Robert N, Laurie Steven S, Macias Brandon R et al.

AI models predicted Spaceflight Associated Neuro-Ocular Syndrome (SANS) from pre-flight OCT scans with moderate-to-high accuracy, suggesting early detection is possible and supporting bedrest as a SANS model.

Vasu Pranav, Dorairaj Emily A, Weinreb Robert N, Huang Alex S, Dorairaj Syril K

In non-diabetic obese patients, GLP-1RAs significantly reduced the risk of primary open-angle glaucoma and ocular hypertension compared to other weight loss medications, suggesting a potential protective effect for eye health.

Fang Raymond, Zhang Pengpeng, Kim Daniel, Kweon Junghun, Sun Cheng, Huang Alex S et al.

Robotic vis-OCT revealed segmental Schlemm's canal anatomy in mice and a segmental pilocarpine response, suggesting glaucoma drug effects vary circumferentially, impacting treatment efficacy.

Dada Tanuj, Gupta Ashi, Beri Nitika, Huang Alex S, Sharma Namrata, Angmo Dewang et al.

This study found that performing glaucoma surgery (BANG) in baseline low aqueous humor outflow regions (temporal quadrant) significantly improved surgical success, suggesting targeted treatment.

Acott Ted S, Fautsch Michael P, Mao Weiming, Ethier C Ross, Huang Alex S, Kelley Mary J et al.

This paper details ex vivo perfusion methods for studying eye pressure regulation, providing standardized tools to better understand outflow function, crucial for glaucoma research and treatment.

Pilotte Julie, Khoury Sami, Tafreshi Ali, Mandel Zachary T, Sharma Svasti V, Vanderklish Peter W et al.

This study found more amyloid-beta (Aβ) in human glaucoma retinas than controls, mapped its distribution, and showed a novel tracer (AMDX-2011) can identify it, suggesting future diagnostic potential.

Bolo Kyle, Apolo Aroca Galo, Pardeshi Anmol A, Chiang Michael, Burkemper Bruce, Xie Xiaobin et al.

Deep learning algorithms on ANTERION AS-OCT accurately detect the scleral spur, outperforming human graders. This enhances angle closure assessment and IOL calculations, improving clinical utility.

Gupta Shikha, Zhang Xiaowei, Panigrahi Arnav, Shakha, Fang Raymond, Strohmaier Clemens A et al.

Childhood glaucoma eyes show fewer, less branched aqueous outflow pathways compared to non-glaucoma eyes. This anatomical difference may explain some surgical failures by creating trabecular-independent outflow resistance.

Schneider Sophie, Kallab Martin, Murauer Olivia, Reisinger Anna-Sophie, Strohmaier Susanne, Huang Alex S et al.

Early bleb vessel density measured by AS-OCTA after Preserflo Microshunt surgery predicts future surgical revisions, offering an objective biomarker for bleb failure risk.

Strohmaier Clemens A, Wanderer Daniel, Zhang Xiaowei, Zhang Hao F, Strohmaier Susanne, Weinreb Robert N et al.

This study found no overall correlation between segmental trabecular meshwork pigmentation and aqueous humor outflow in human eyes, suggesting pigmentation shouldn't guide glaucoma surgeries.

Strohmaier Clemens A, McDonnell Fiona S, Zhang Xiaowei, Wanderer Daniel, Stamer W Daniel, Weinreb Robert N et al.

This study found that high-flow regions of the eye's outflow pathway have significantly better outflow facility than low-flow regions, indicating uneven drainage efficiency across the trabecular meshwork.

Dada Tanuj, Bukke Anand Naik, Huang Alex S, Sharma Namrata, Verma Saurabh

Aqueous angiography showed that ab-interno goniectomy in glaucoma patients can recruit new outflow channels in previously non-functional areas, demonstrating surgical efficacy in improving aqueous drainage.

Panigrahi Arnav, Huang Alex S, Arora Monika, Kumari Somya, Mahalingam Karthikeyan, Gupta Viney et al.

Indocyanine green improved Schlemm canal identification during trabeculotomy in congenital glaucoma, enhancing surgical precision, especially in eyes with poor angle visualization.

Lee Jong Yeon, Heilweil Gad, Le Phuc, Saraswathy Sindhu, Hong Young-Kwon, Girkin Christopher A et al.

This study found subconjunctival blebs drain via lymphatic vessels with valve-like structures. Understanding this bleb-related lymphatic outflow could improve glaucoma surgery and drug delivery.

Narayanaswamy Arun, Thakur Sahil, Nongpiur Monisha E, Schmetterer Leopold, Hong Young-Kwon, Huang Alex S et al.

This review highlights emerging evidence of lymphatic channels in ocular outflow pathways, suggesting a "uveolymphatic" route for aqueous humor. This finding offers new insights into glaucoma pathophysiology and potential therapeutic targets.

Lee Jong Yeon, Akiyama Goichi, Saraswathy Sindhu, Xie Xiaobin, Pan Xiaojing, Hong Young-Kwon et al.

This review highlights modern imaging of aqueous humor outflow pathways, revealing new biological insights crucial for understanding and improving glaucoma therapies targeting IOP reduction.

Burn Jessica B, Huang Alex S, Weber Arthur J, Komáromy Andras M, Pirie Chris G

Aqueous angiography in dogs revealed in vivo aqueous humor outflow pathways, showing sectoral patterns and pulsatile flow. This technique has potential for evaluating outflow in this important animal model.

Stenger Michael B, Laurie Steven S, Sadda SriniVas R, Sadun Alfredo A, Macias Brandon R, Huang Alex S

Huang Alex S, Stenger Michael B, Macias Brandon R

Spaceflight-induced ocular changes (SANS) in astronauts, particularly optic disc edema, are being studied. Understanding SANS may offer insights into Earth-based eye diseases like glaucoma.

Hu Man, Wang Huaizhou, Huang Alex S, Li Li, Shi Yan, Xu Yongli et al.

Microcatheter trabeculotomy (MAT) effectively lowered eye pressure in children with congenital glaucoma after prior surgery failures, showing promise for these challenging cases.

Huang Alex S, Penteado Rafaella C, Saha Sajib K, Do Jiun L, Ngai Philip, Hu Zhihong et al.

Fluorescein aqueous angiography in live humans revealed segmental outflow patterns colocalizing with episcleral veins. This allows assessing interventions' effects on aqueous humor outflow.