Mao Weiming

Acott Ted S, Fautsch Michael P, Mao Weiming, Ethier C Ross, Huang Alex S, Kelley Mary J et al.

This paper details ex vivo perfusion methods for studying eye pressure regulation, providing standardized tools to better understand outflow function, crucial for glaucoma research and treatment.

Sugali Chenna Kesavulu, Rayana Naga Pradeep, Dai Jiannong, Harvey Devon H, Dhamodaran Kamesh, Mao Weiming

GSK3β inhibitors (Wnt activators) were studied, finding they inhibit TGFβ-induced TM changes and ocular hypertension. This suggests a potential therapeutic strategy for primary open-angle glaucoma.

Rayana Naga Pradeep, Sugali Chenna Kesavulu, Dai Jiannong, Peng Michael, Liu Shaohui, Zhang Yucheng et al.

CRISPR interference effectively lowered TGFβ2 levels and prevented ocular hypertension in a mouse model. This suggests a promising gene therapy approach for TGFβ2-induced glaucoma.

Webber Hannah C, Bermudez Jaclyn Y, Millar J Cameron, Mao Weiming, Clark Abbot F

Wnt/β-catenin signaling increases K-cadherin in trabecular meshwork, enhancing cell resistance and lowering IOP. This suggests K-cadherin could be a therapeutic target for glaucoma.

Montecchi-Palmer Michela, Bermudez Jaclyn Y, Webber Hannah C, Patel Gaurang C, Clark Abbot F, Mao Weiming

This study found that TGFβ2, elevated in glaucoma, induces problematic cellular networks (CLANs) in eye drainage cells via multiple pathways. Inhibiting these pathways, especially ROCK, can prevent and even reverse these CLANs, offering potential glaucoma treatments.

Bermudez Jaclyn Y, Webber Hannah C, Patel Gaurang C, Liu Xiangyang, Cheng Yi-Qiang, Clark Abbot F et al.

This study found histone hyperacetylation increases glaucoma-associated TGFβ2 and IOP in the trabecular meshwork, suggesting epigenetic mechanisms initiate glaucomatous damage.

McDowell Colleen M, Hernandez Humberto, Mao Weiming, Clark Abbot F

Gremlin was shown to induce ocular hypertension in mice by increasing ECM proteins via the Smad3 pathway, highlighting gremlin's role in glaucoma pathology and potential as a therapeutic target.

Mao Weiming, Liu Yang, Wordinger Robert J, Clark Abbot F

Researchers developed a magnetic bead method to isolate mouse trabecular meshwork (MTM) cells. This technique efficiently yields pure MTM cells exhibiting TM markers and steroid response, simplifying glaucoma research in mice.

Mao Weiming, Millar J Cameron, Wang Wan-Heng, Silverman Sean M, Liu Yang, Wordinger Robert J et al.

This study confirmed a functional canonical Wnt pathway in the human trabecular meshwork. This pathway, not non-canonical Wnt signaling, regulates intraocular pressure, suggesting a potential therapeutic target for glaucoma.

Mao Weiming, Tovar-Vidales Tara, Yorio Thomas, Wordinger Robert J, Clark Abbot F

Perfusion-cultured bovine eye segments reliably mimic human dexamethasone-induced ocular hypertension and myocilin changes, providing a fast, affordable model for glaucoma research and trabecular outflow mechanisms.

Sethi Anirudh, Mao Weiming, Wordinger Robert J, Clark Abbot F

TGFβ induces LOX gene expression in human TM cells via Smad and non-Smad pathways, suggesting complex regulation of ECM cross-linking that may contribute to glaucoma-related IOP elevation.