Bermudez Jaclyn Y

Webber Hannah C, Bermudez Jaclyn Y, Millar J Cameron, Mao Weiming, Clark Abbot F

Wnt/β-catenin signaling increases K-cadherin in trabecular meshwork, enhancing cell resistance and lowering IOP. This suggests K-cadherin could be a therapeutic target for glaucoma.

Montecchi-Palmer Michela, Bermudez Jaclyn Y, Webber Hannah C, Patel Gaurang C, Clark Abbot F, Mao Weiming

This study found that TGFβ2, elevated in glaucoma, induces problematic cellular networks (CLANs) in eye drainage cells via multiple pathways. Inhibiting these pathways, especially ROCK, can prevent and even reverse these CLANs, offering potential glaucoma treatments.

Bermudez Jaclyn Y, Webber Hannah C, Patel Gaurang C, Liu Xiangyang, Cheng Yi-Qiang, Clark Abbot F et al.

This study found histone hyperacetylation increases glaucoma-associated TGFβ2 and IOP in the trabecular meshwork, suggesting epigenetic mechanisms initiate glaucomatous damage.