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Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma.
Rayana Naga Pradeep, Sugali Chenna Kesavulu, Dai Jiannong, Peng Michael, Liu Shaohui, Zhang Yucheng et al.
Invest Ophthalmol Vis SciSep 202116 citationsBasic Science
CRISPR interference effectively lowered TGFβ2 levels and prevented ocular hypertension in a mouse model. This suggests a promising gene therapy approach for TGFβ2-induced glaucoma.