Macias Brandon R

Huang Alex S, Jalili Jalil, Walker Evan, Weinreb Robert N, Laurie Steven S, Macias Brandon R et al.

AI models predicted Spaceflight Associated Neuro-Ocular Syndrome (SANS) from pre-flight OCT scans with moderate-to-high accuracy, suggesting early detection is possible and supporting bedrest as a SANS model.

Brunstetter Tyson J, Zwart Sara R, Brandt Keith, Brown David M, Clemett Simon J, Douglas Grace L et al.

A severe SANS case in an astronaut with genetic predispositions showed significant ocular changes and improvement, possibly linked to B-vitamin supplementation or reduced CO2, highlighting potential interventions for spaceflight-induced vision issues.

Sibony Patrick A, Laurie Steven S, Ferguson Connor R, Pardon Laura P, Young Millennia, Rohlf F James et al.

Comparing SANS and IIH, this study found significant differences in disc edema and ocular deformation patterns, suggesting SANS involves biomechanical factors beyond intracranial pressure alone.

Ferguson Connor R, Pardon Laura P, Laurie Steven S, Young Millennia H, Gibson C Robert, Brunstetter Tyson J et al.

Astronauts developed choroidal folds during spaceflight, progressing with mission duration. This suggests unique mechanisms compared to Earth-based conditions, aiding in understanding spaceflight-associated eye changes.

Pardon Laura P, Greenwald Scott H, Ferguson Connor R, Patel Nimesh B, Young Millennia, Laurie Steven S et al.

This study found astronauts with smaller preflight optic cup morphology are more prone to spaceflight-induced optic disc edema, suggesting targeted monitoring and countermeasures for those at higher risk.

Pardon Laura P, Macias Brandon R, Ferguson Connor R, Greenwald Scott H, Ploutz-Snyder Robert, Alferova Irina V et al.

Long-duration spaceflight caused optic nerve head thickening and macular thinning. Brief lower-body negative pressure didn't reverse these changes, suggesting longer interventions or other factors are needed to mitigate spaceflight-associated neuro-ocular syndrome.

Macias Brandon R, Ferguson Connor R, Patel Nimesh, Gibson C, Samuels Brian C, Laurie Steven S et al.

One-year spaceflight caused progressive optic disc edema and choroidal changes in astronauts, suggesting ocular risks may worsen with longer missions, necessitating further monitoring for extended space travel.

Sater Stuart H, Sass Austin M, Rohr Jesse J, Marshall-Goebel Karina, Ploutz-Snyder Robert J, Ethier C Ross et al.

Automated MRI quantified posterior globe flattening in astronauts post-spaceflight, finding significant displacement that only partially resolved after one year, improving SANS understanding.

Macias Brandon R, Patel Nimesh B, Gibson C Robert, Samuels Brian C, Laurie Steven S, Otto Christian et al.

This study found astronauts developed optic disc edema and choroidal thickening during spaceflight, and persistent axial length changes, highlighting ocular risks for long-duration missions.

Stenger Michael B, Laurie Steven S, Sadda SriniVas R, Sadun Alfredo A, Macias Brandon R, Huang Alex S

Huang Alex S, Stenger Michael B, Macias Brandon R

Spaceflight-induced ocular changes (SANS) in astronauts, particularly optic disc edema, are being studied. Understanding SANS may offer insights into Earth-based eye diseases like glaucoma.