Aqueous humour outflow imaging: seeing is believing.
Lee Jong Yeon, Akiyama Goichi, Saraswathy Sindhu, Xie Xiaobin, Pan Xiaojing, Hong Young-Kwon, Huang Alex S
AI Summary
This review highlights modern imaging of aqueous humor outflow pathways, revealing new biological insights crucial for understanding and improving glaucoma therapies targeting IOP reduction.
Abstract
Elevated intraocular pressure (IOP) is the primary risk factor for blindness in glaucoma. IOP is determined by many factors including aqueous humour production and aqueous humour outflow (AHO), where AHO disturbance represents the primary cause of increased IOP. With the recent development of new IOP lowering drugs and Minimally Invasive Glaucoma Surgeries (MIGS), renewed interest has arisen in shedding light on not only how but where AHO is occurring for the trabecular/conventional, uveoscleral/unconventional, and subconjunctival outflow pathways. Historical studies critical to understanding outflow anatomy will be presented, leading to the development of modern imaging methods. New biological behaviours uncovered by modern imaging methods will be discussed with relevance to glaucoma therapies emphasized.
MeSH Terms
Shields Classification
Key Concepts4
Modern imaging methods are uncovering new biological behaviours of aqueous humour outflow with relevance to glaucoma therapies.
Elevated intraocular pressure (IOP) is the primary risk factor for blindness in glaucoma.
Aqueous humour outflow (AHO) disturbance represents the primary cause of increased intraocular pressure (IOP) in glaucoma.
New intraocular pressure lowering drugs and Minimally Invasive Glaucoma Surgeries (MIGS) have renewed interest in understanding where aqueous humour outflow (AHO) occurs for the trabecular/conventional, uveoscleral/unconventional, and subconjunctival outflow pathways.
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