Nongpiur Monisha E

Chuangsuwanich Thanadet, Nongpiur Monisha E, Braeu Fabian A, Prasad Shimna Clara, Tun Tin A, Thiéry Alexandre et al.

ONH tissue strain significantly improved glaucoma VF defect classification (e.g., superior arcuate, AUC 0.83 to 0.87). Neuroretinal rim strain, particularly inferotemporal, was key, suggesting it's a critical biomechanical biomarker for axonal injury and disease monitoring.

Servillo Andrea, Tun Tin A, Yoo Chungkwon, Kumar Rajesh S, Baskaran Mani, Nongpiur Monisha E et al.

This study found laser iridotomy sustained angle widening in two-thirds of patients. Persistent angle closure, seen in 33%, was predicted by a thicker iris and younger age, guiding personalized treatment.

Umapathi Ruthra M, Hliang Tin Nwe, Koh Audrey Su-Min, Sim Charmaine, Perera Shamira A, Husain Rahat et al.

This study found 38% of asymptomatic primary angle closure glaucoma patients presented with severe visual field loss. Sex-specific biometric differences highlight the need for integrated risk assessment and early detection.

Prasad Shimna C, Umapathi Ruthra M, Hlaing Tin Nwe, Atalay Eray, Girard Michael J, Aung Tin et al.

This study found that in primary angle-closure glaucoma with asymmetrical visual field loss, the worse eye had significantly thinner central corneal thickness and higher initial intraocular pressure, impacting disease severity.

Chuangsuwanich Thanadet, Nongpiur Monisha E, Braeu Fabian A, Tun Tin A, Thiery Alexandre, Perera Shamira et al.

This study found that combining optic nerve structure with biomechanical data (IOP-induced tissue strains) significantly improves prediction of visual field loss in glaucoma, highlighting biomechanics' clinical importance for functional prognosis.

Tan Shayne S, Tun Tin A, Nongpiur Monisha E

Tan Royston K Y, Ng Gim Yew, Tun Tin A, Braeu Fabian A, Nongpiur Monisha E, Aung Tin et al.

Finite element analysis showed iris thickness, convexity, stiffness, and anterior chamber dimensions significantly influence angle narrowing during pupil dilation, guiding risk assessment for angle-closure glaucoma.

Tun Tin A, Atalay Eray, Liu Arthur, Liu Chang, Aung Tin, Nongpiur Monisha E

OCTA showed optic disc and macular microvasculature was significantly reduced only in primary angle closure glaucoma, not earlier stages, suggesting vascular changes correlate with glaucoma progression.

Tan Shayne S, Tun Tin A, Aung Tin, Nongpiur Monisha E

This study found primary angle closure glaucoma eyes have higher initial IOP and narrower anterior segments than fellow eyes, suggesting these factors increase glaucoma risk after LPI.

Tan Royston K Y, Panda Satish K, Braeu Fabian A, Muralidharan Arumugam R, Nongpiur Monisha E, Chan Anita S Y et al.

This study found porcine iris stroma is permeable and biomechanically distinct from the dilator muscle, offering insights into angle-closure glaucoma mechanisms.

Chong Rachel S, Li Hengtong, Cheong Alex J Y, Fan Qiao, Koh Victor, Raghavan Lavanya et al.

This study found a strong, bidirectional genetic link between myopia and glaucoma, mainly mediated by intraocular pressure. IOP-lowering treatment may benefit myopic eyes with glaucoma.

Teo Zhen Ling, Soh Zhi Da, Tham Yih-Chung, Yu Marco, Chee Miao Li, Thakur Sahil et al.

This study found 3.50% of people developed primary angle-closure disease in 6 years. Older age, higher eye pressure, and shallower anterior chambers increased risk, guiding screening efforts.

Narayanaswamy Arun, Thakur Sahil, Nongpiur Monisha E, Schmetterer Leopold, Hong Young-Kwon, Huang Alex S et al.

This review highlights emerging evidence of lymphatic channels in ocular outflow pathways, suggesting a "uveolymphatic" route for aqueous humor. This finding offers new insights into glaucoma pathophysiology and potential therapeutic targets.

Fenwick Eva K, Ozdemir Semra, Man Ryan E K, Baid Drishti, Htoon Hla M, Gan Alfred T L et al.

Researchers developed and validated Glau-U, a new glaucoma-specific utility instrument. It found significant utility decrements with advanced glaucoma, making it valuable for cost-effectiveness analyses and resource allocation in glaucoma care.

Liu Chang, Umapathi Ruthra M, Atalay Eray, Schmetterer Leopold, Husain Rahat, Boey Pui Yi et al.

Latanoprost-induced IOP reduction in treatment-naive eyes significantly correlated with increased optic nerve head and peripapillary capillary vessel density, suggesting improved ocular microperfusion as a glaucoma treatment mechanism.

Nongpiur Monisha E, Verma Sushma, Tun Tin A, Wong Tina T, Perera Shamira A, Aung Tin

This study found plateau iris is more common in severe primary angle closure glaucoma, suggesting it may contribute to disease progression and severity.

Liu Chang, Nongpiur Monisha E, Cheng Ching-Yu, Khor Chiea-Chuen, Yu Marco, Husain Rahat et al.

Researchers found that a specific gene (EPDR1) and a higher genetic risk score are linked to more severe primary angle-closure glaucoma, potentially identifying individuals at risk for aggressive disease.

Liu Chang, Nongpiur Monisha E, Khor Chiea-Chuen, Vithana Eranga N, Aung Tin

Recent GWAS identified new genetic loci for primary angle closure glaucoma, showing partial overlap with open-angle glaucoma. This genetic insight improves understanding of disease mechanisms, potentially guiding new therapies.

Nongpiur Monisha E, Tun Tin A, Aung Tin

AS-OCT in primary angle closure disease enhances understanding of risk factors and mechanisms, offering a key clinical role in diagnosis and predicting outcomes.

Wang Xiaofei, Rumpel Helmut, Baskaran Mani, Tun Tin A, Strouthidis Nicholas, Perera Shamira A et al.

Glaucoma patients showed tauter optic nerves during eye movements and more protruding globes than normal subjects, suggesting increased optic nerve head stress in anatomically predisposed individuals.

Tun Tin A, Wang Xiaofei, Baskaran Mani, Nongpiur Monisha E, Tham Yih-Chung, Perera Shamira A et al.

This study found the peripapillary sclera becomes more v-shaped (orbital peak) with age, potentially impacting optic nerve head biomechanics.

Nongpiur Monisha E, Khor Chiea-Chuen, Cheng Ching-Yu, Husain Rahat, Boey Pui Yi, Chew Annabel et al.

Studying PACG detection, combining genetic data with anterior segment imaging (ACD) showed only a non-significant, marginal improvement over imaging alone.

Narayanaswamy Arun, Nai Mui Hoon, Nongpiur Monisha E, Htoon Hla Myint, Thomas Anoop, Sangtam Tiakumzuk et al.

This study found primary angle closure glaucoma (PACG) iris is significantly stiffer than normal or primary open angle glaucoma (POAG) iris, suggesting iris biomechanics play a role in angle closure pathogenesis.

Fan Kenric Rui-Pin, Baskaran Mani, Nongpiur Monisha E, Htoon Hla Mynt, de Leon John Mark S, Perera Shamira A et al.

This study investigated Copolymer-1's neuroprotective effect in acute angle closure glaucoma. It found no difference in visual field progression or RNFL thickness, but Copolymer-1 improved mean deviation, suggesting potential visual function benefits.

Verma Sushma, Nongpiur Monisha E, Husain Rahat, Wong Tina T, Boey Pui Yi, Quek Desmond et al.

This study found corneal endothelial cell density and morphology are not significantly different across the primary angle closure spectrum, suggesting minimal long-term impact on these cells.