Wong Tina T

Tan See Teng, Tan Ting Fang, Syn Yamon Thant, Chu Alice, Htoon Hla Myint, Perera Shamira A et al.

Combined iStent and cataract surgery in Asian eyes showed sustained 3-year reductions in IOP and medication burden, with over half achieving surgical success, supporting its role as an effective, minimally invasive treatment.

Gupta Preeti, Thakur Sahil, Wong Chiew Meng Johnny, Man Ryan E K, Fenwick Eva K, Sabanayagam Charumathi et al.

Glaucoma affects 5.1% of older Singaporeans, with higher rates in Malays/Indians and increasing prevalence projected. This highlights the urgent need for targeted screening and early intervention strategies, especially for specific ethnic groups.

Lo Phey Feng, Gunawan Merry, Yap Zhu Li, Leong Carol, Kwek Fuxuan, Varadarajan Jayasudha et al.

Valproic acid, combined with low-dose MMC, improved bleb survival and reduced fibrosis after minimally invasive glaucoma surgery in rabbits. This suggests VPA could be a safe, versatile antifibrotic agent.

Tan Shayne S, Wong Tina T

This review highlights current glaucoma drug delivery systems (Durysta, iDose TR) and emerging gene therapy/nanoparticle approaches to overcome eyedrop limitations, aiming for more effective, sustained IOP control and neuroprotection.

Umapathi Ruthra M, Hliang Tin Nwe, Koh Audrey Su-Min, Sim Charmaine, Perera Shamira A, Husain Rahat et al.

This study found 38% of asymptomatic primary angle closure glaucoma patients presented with severe visual field loss. Sex-specific biometric differences highlight the need for integrated risk assessment and early detection.

Umapathi Ruthra, Yu Marco, Cheng Ching-Yu, Najjar Raymond P, Husain Rahat, Ho Ching Lin et al.

This study identified three distinct angle closure subtypes using ASOCT. A spacious anterior chamber subtype was linked to stable PACS, while smaller dimensions were associated with glaucoma progression.

Chua Jacqueline, Li Chi, Chong Rachel, Wong Tina T, Husain Rahat, Aung Tin et al.

Compensating RNFL thickness for anatomical factors significantly improved its correlation with visual field loss in glaucoma, potentially enhancing detection of localized damage.

Chew Annabel Cy, Htoon Hla Myint, Perera Shamira A, Aung Tin, Lin Ho Ching, Husain Rahat et al.

Phacotrabeculectomy effectively lowered IOP for 13 years, reduced medication dependence, and improved vision in glaucoma patients, demonstrating its long-term safety and efficacy.

Finkelstein Maxwell Toan, Nongpiur Monisha Esther, Husain Rahat, Perera Shamira, Baskaran Mani, Wong Tina T et al.

Handheld chromatic pupillometry reliably detected glaucoma in highly myopic eyes, showing reduced pupillary responses. This offers a useful, objective tool for diagnosing glaucoma in high myopia.

Lee Yi Fang, Chay Junxing, Husain Rahat, Wong Tina T, Ho Ching Lin, Lamoureux Ecosse L et al.

This 3-year study found virtual glaucoma clinics are safe, time-efficient, and cost-effective with low progression, significantly expanding healthcare capacity for glaucoma management.

Seet Li-Fong, Yap Zhu Li, Chu Stephanie W L, Toh Li Zhen, Ibrahim Farah Ilyana, Teng Xiao et al.

This study found valproic acid combined with low-dose mitomycin C in a rabbit MIGS model was less toxic and more effective at reducing scarring than high-dose mitomycin C, improving surgical outcomes.

Narayanaswamy Arun, Thakur Sahil, Nongpiur Monisha E, Schmetterer Leopold, Hong Young-Kwon, Huang Alex S et al.

This review highlights emerging evidence of lymphatic channels in ocular outflow pathways, suggesting a "uveolymphatic" route for aqueous humor. This finding offers new insights into glaucoma pathophysiology and potential therapeutic targets.

Yap Zhu Li, Seet Li-Fong, Chu Stephanie Wl, Toh Li Zhen, Ibrahim Farah Ilyana, Wong Tina T

Valproic acid improved bleb survival and morphology in a rabbit MIGS model by reducing scar tissue and promoting healthier collagen, suggesting a promising adjunctive therapy for glaucoma surgery.

Huang Olivia S, Chew Annabel C Y, Finkelstein Eric A, Wong Tina T, Lamoureux Ecosse L

An asynchronous virtual glaucoma clinic for low-risk patients was found to be time-efficient, cost-saving, and well-received, freeing up conventional clinic resources for complex cases.

Huang Olivia S, Seet Li-Fong, Ho Henrietta W, Chu Stephanie W, Narayanaswamy Arun, Perera Shamira A et al.

Glaucoma eyes showed increased iris AQP1/2 and lower aqueous osmolality, suggesting iris involvement in altered fluid dynamics. This indicates common glaucoma pathophysiology.

Wong Chee Wai, Metselaar Josbert M, Storm Gert, Wong Tina T

This review highlights novel drug delivery systems for anterior segment inflammation, finding they offer sustained, targeted drug release, potentially replacing daily eye drops to improve treatment efficacy and patient compliance.

Soh Zhi Da, Chee Miao Li, Thakur Sahil, Tham Yih Chung, Tao Yijin, Lim Zhi Wei et al.

This study identified optimal vertical cup-to-disc ratio (VCDR) cut-offs (≥0.60, or ≥0.65 for larger discs, with ≥0.20 asymmetry) for glaucoma screening in multi-ethnic Asians, improving diagnostic balance.

Nongpiur Monisha E, Verma Sushma, Tun Tin A, Wong Tina T, Perera Shamira A, Aung Tin

This study found plateau iris is more common in severe primary angle closure glaucoma, suggesting it may contribute to disease progression and severity.

Chong Rachel S, Crowston Jonathan G, Wong Tina T

Experimental models of glaucoma surgery reveal wound healing mechanisms causing scarring and poor outcomes, guiding future research to improve surgical success and patient care.

Liu Chang, Nongpiur Monisha E, Cheng Ching-Yu, Khor Chiea-Chuen, Yu Marco, Husain Rahat et al.

Researchers found that a specific gene (EPDR1) and a higher genetic risk score are linked to more severe primary angle-closure glaucoma, potentially identifying individuals at risk for aggressive disease.

Nongpiur Monisha E, Khor Chiea-Chuen, Cheng Ching-Yu, Husain Rahat, Boey Pui Yi, Chew Annabel et al.

Studying PACG detection, combining genetic data with anterior segment imaging (ACD) showed only a non-significant, marginal improvement over imaging alone.

Narayanaswamy Arun, Nai Mui Hoon, Nongpiur Monisha E, Htoon Hla Myint, Thomas Anoop, Sangtam Tiakumzuk et al.

This study found primary angle closure glaucoma (PACG) iris is significantly stiffer than normal or primary open angle glaucoma (POAG) iris, suggesting iris biomechanics play a role in angle closure pathogenesis.

Verma Sushma, Nongpiur Monisha E, Husain Rahat, Wong Tina T, Boey Pui Yi, Quek Desmond et al.

This study found corneal endothelial cell density and morphology are not significantly different across the primary angle closure spectrum, suggesting minimal long-term impact on these cells.

Seet Li Fong, Tan Yang Fei, Toh Li Zhen, Chu Stephanie Wl, Lee Ying Shi, Venkatraman Subbu S et al.

This study showed that silencing SPARC with targeted siRNA reduced collagen deposition in a mouse model of conjunctival scarring after glaucoma surgery, suggesting a safe, feasible antifibrotic therapy.

Wong Tina T, Aung Tin, Ho Ching Lin

Switching glaucoma patients from latanoprost to low-preservative tafluprost improved ocular surface disease and symptoms, offering a better-tolerated treatment option with comparable IOP control.