Lee Ying Shi

Chong Rachel S, Busoy Joanna M F, Tan Bingyao, Yeo Sia Wey, Lee Ying Shi, Barathi Amutha V et al.

This mouse model of acute OHT with angle closure features caused RGC loss, retinal dysfunction, and focal ischemia without confounding injury, providing a valuable tool for studying this severe blinding disease.

Seet Li Fong, Tan Yang Fei, Toh Li Zhen, Chu Stephanie Wl, Lee Ying Shi, Venkatraman Subbu S et al.

This study showed that silencing SPARC with targeted siRNA reduced collagen deposition in a mouse model of conjunctival scarring after glaucoma surgery, suggesting a safe, feasible antifibrotic therapy.

Chong Rachel Shujuan, Lee Ying Shi, Chu Stephanie Wai Ling, Toh Li Zhen, Wong Tina Tzee Ling

MCP-1 inhibition in mice prevented conjunctival fibrosis after glaucoma surgery, showing superior bleb survival and less cellular toxicity than MMC. This suggests a safer antifibrotic alternative for patients.