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Targeted therapy for the post-operative conjunctiva: SPARC silencing reduces collagen deposition.
Seet Li Fong, Tan Yang Fei, Toh Li Zhen, Chu Stephanie Wl, Lee Ying Shi, Venkatraman Subbu S et al.
Br J OphthalmolJul 201817 citationsBasic Science
This study showed that silencing SPARC with targeted siRNA reduced collagen deposition in a mouse model of conjunctival scarring after glaucoma surgery, suggesting a safe, feasible antifibrotic therapy.