Perera Shamira

Chuangsuwanich Thanadet, Nongpiur Monisha E, Braeu Fabian A, Prasad Shimna Clara, Tun Tin A, Thiéry Alexandre et al.

ONH tissue strain significantly improved glaucoma VF defect classification (e.g., superior arcuate, AUC 0.83 to 0.87). Neuroretinal rim strain, particularly inferotemporal, was key, suggesting it's a critical biomechanical biomarker for axonal injury and disease monitoring.

Umapathi Ruthra, Yu Marco, Cheng Ching-Yu, Najjar Raymond P, Husain Rahat, Ho Ching Lin et al.

This study identified three distinct angle closure subtypes using ASOCT. A spacious anterior chamber subtype was linked to stable PACS, while smaller dimensions were associated with glaucoma progression.

Porporato Natalia, Xu Benjamin Y, Tan Bingyao, Chang Yu Q, Tun Tin A, Perera Shamira et al.

Novel HP-OCT reliably assesses angle closure, showing excellent reproducibility and good agreement with SS-OCT/gonioscopy, while uniquely visualizing distal outflow pathways, enhancing glaucoma research.

Chuangsuwanich Thanadet, Nongpiur Monisha E, Braeu Fabian A, Tun Tin A, Thiery Alexandre, Perera Shamira et al.

This study found that combining optic nerve structure with biomechanical data (IOP-induced tissue strains) significantly improves prediction of visual field loss in glaucoma, highlighting biomechanics' clinical importance for functional prognosis.

Finkelstein Maxwell Toan, Nongpiur Monisha Esther, Husain Rahat, Perera Shamira, Baskaran Mani, Wong Tina T et al.

Handheld chromatic pupillometry reliably detected glaucoma in highly myopic eyes, showing reduced pupillary responses. This offers a useful, objective tool for diagnosing glaucoma in high myopia.

Chuangsuwanich Thanadet, Tun Tin A, Braeu Fabian A, Wang Xiaofei, Chin Zhi Yun, Panda Satish K et al.

This study found normal-tension glaucoma patients experience greater optic nerve head strain from adduction than high-tension patients, suggesting gaze-induced stress may contribute to NTG progression.

Fenwick Eva K, Man Ryan E K, Lim Belicia, Baskaran Mani, Nongpiur Monisha, Sng Chelvin C A et al.

GlauCAT-Asian efficiently and precisely measures glaucoma's patient-centered impact, showing promise as a clinical tool for monitoring disease progression and treatment effectiveness.

Braeu Fabian A, Chuangsuwanich Thanadet, Tun Tin A, Perera Shamira, Husain Rahat, Thiery Alexandre H et al.

AI can predict optic nerve head robustness from a single OCT scan, potentially identifying glaucoma patients at higher risk for rapid vision loss, without needing invasive biomechanical testing.

Tran Luke, Vo Joanne, Bell Katharina, Perera Shamira, Crowston Jonathan

This meta-analysis found adjunctive bevacizumab with Ahmed valve surgery for refractory glaucoma did not significantly improve pressure, success, or complications, suggesting its clinical benefit is unproven and requires larger studies.

Chuangsuwanich Thanadet, Tun Tin A, Braeu Fabian A, Wang Xiaofei, Chin Zhi Yun, Panda Satish Kumar et al.

This study found higher optic nerve head strain from elevated pressure correlated with worse vision in high-tension glaucoma, but not normal-tension glaucoma, suggesting different disease mechanisms.

Panda Satish K, Cheong Haris, Tun Tin A, Chuangsuwanich Thanadet, Kadziauskiene Aiste, Senthil Vijayalakshmi et al.

This study found that the 3D configuration of central retinal vessels, analyzed by AI, is a superior glaucoma diagnostic marker compared to standard RNFL thickness, potentially improving early detection.

Najjar Raymond P, Rukmini A V, Finkelstein Maxwell T, Nusinovici Simon, Mani Baskaran, Nongpiur Monisha Esther et al.

Handheld chromatic pupillometry accurately and rapidly detects functional loss in glaucoma across all severities, offering a promising objective screening and diagnostic tool.

Panda Satish K, Cheong Haris, Tun Tin A, Devella Sripad K, Senthil Vijayalakshmi, Krishnadas Ramaswami et al.

AI deep learning accurately identified novel structural optic nerve head biomarkers from OCTs, revealing how ONH morphology changes in glaucoma and offering a robust diagnostic tool.

Porporato Natalia, Tun Tin A, Baskaran Mani, Wong Damon W K, Husain Rahat, Fu Huazhu et al.

A deep learning algorithm accurately detected gonioscopic angle closure from SS-OCT scans, offering a promising foundation for future automated, non-contact glaucoma screening.

Liu Chang, Nongpiur Monisha E, Cheng Ching-Yu, Khor Chiea-Chuen, Yu Marco, Husain Rahat et al.

Researchers found that a specific gene (EPDR1) and a higher genetic risk score are linked to more severe primary angle-closure glaucoma, potentially identifying individuals at risk for aggressive disease.

Cheong Haris, Devalla Sripad Krishna, Pham Tan Hung, Zhang Liang, Tun Tin Aung, Wang Xiaofei et al.

DeshadowGAN, a deep learning tool, effectively removed blood vessel shadows from ONH OCT images, improving image quality. This enhances OCT analysis, potentially aiding diagnosis and prognosis in ocular pathologies.

Porporato Natalia, Baskaran Mani, Perera Shamira, Tun Tin A, Sultana Rehena, Tan Marcus et al.

This study found a single superoinferior SS-OCT scan (80°-260°) best detects angle closure, outperforming other scans and suggesting 360° evaluation isn't always necessary for diagnosis.

Porporato Natalia, Baskaran Mani, Tun Tin A, Sultana Rehena, Tan Marcus, Quah Joanne HuiMin et al.

This study found anterior chamber depth and lens vault significantly contribute to diagnostic disagreement between AS-OCT and gonioscopy in angle closure assessment, impacting clinical interpretation.

Nongpiur Monisha E, Khor Chiea-Chuen, Cheng Ching-Yu, Husain Rahat, Boey Pui Yi, Chew Annabel et al.

Studying PACG detection, combining genetic data with anterior segment imaging (ACD) showed only a non-significant, marginal improvement over imaging alone.

Goh David, de Korne Dirk F, Ho Henrietta, Mathur Ranjana, Chakraborty Bibhas, Van Hai Nguyen et al.

This study found that managing stable glaucoma in primary eye care is as safe and effective as specialist care, significantly lowering costs and enhancing collaboration.

Chiam Nathalie, Baskaran Mani, Li Zheng, Perera Shamira, Goh David, Husain Rahat et al.

This study found older age, family history, higher IOP, thinner CCT, and myopia are linked to primary open-angle glaucoma in Chinese Singaporeans; surprisingly, current smoking was protective for normal-tension glaucoma.

Koh Victor, Chua Jacqueline, Shi Yuan, Thakku Sri Gowtham, Lee Ryan, Nongpiur Monisha E et al.

Studying Asian eyes, higher iris crypt grading was linked to lower acute angle closure risk. Assessing iris crypts could help predict acute angle closure.

Wang Xiaofei, Beotra Meghna R, Tun Tin Aung, Baskaran Mani, Perera Shamira, Aung Tin et al.

This study found horizontal eye movements cause significant optic nerve head strains, comparable to those from acute IOP elevation. This suggests eye movement-induced strain might contribute to optic nerve damage.

Siak Jay, Quek Desmond, Nongpiur Monisha E, Ho Sue-Wei, Htoon Hla M, Perera Shamira et al.

Phacoemulsification significantly opened the anterior chamber angle and similarly reduced IOP in both closed-angle and open-angle glaucoma patients. This suggests phacoemulsification benefits both glaucoma types.

Chan Hiok Hong, Wong Tina T, Lamoureux Ecosse, Perera Shamira

Singaporean Chinese glaucoma patients mostly accept sustained drug delivery, preferring punctal plugs. This suggests these systems are viable alternatives to daily drops, especially for males, non-subsidized patients, and those with bilateral glaucoma.