Zhang Liang

Huang Yujuan, Gui Mi, Kong Xiangbin, Li Taozheng, Xu Zikang, Li Jing et al.

Anti-VEGF therapy in PDR was studied. GALNS depletion after treatment was identified as a pro-fibrotic factor, potentially aiding perioperative risk stratification for patients.

Zhuang Xuenan, Li Miaoling, Mi Lan, Zhang Xiongze, Pu Jiaxin, He Guiqin et al.

This study identified molecular changes during anti-VEGF treatment for nAMD. FGA, TALDO1, and ASPH reduction correlated with better response, while YIPF3 decrease linked to poorer outcomes, offering insights into treatment efficacy and variability.

Chen Sheng, Tian Meiwen, Zhang Liang, Hu Chenli, Liu Ke, Qin Bo et al.

FCVB implantation combined with silicone oil showed high retinal reattachment rates and improved vision in severe retinal detachment, offering a promising, safer alternative to traditional tamponades.

Nusinovici Simon, Zhang Liang, Chai Xiaoran, Zhou Lei, Tham Yih Chung, Vasseneix Caroline et al.

Machine learning identified modifiable and non-modifiable risk factors for major eye diseases. Key finding: POAG had the highest modifiable risk factor contribution (35%), with IOP and BMI being relevant.

Chai Xiaoran, Low Kok Yao, Tham Yih Chung, Chee Miao Li, Thakur Sahil, Zhang Liang et al.

This multi-ethnic study found that among 35 glaucoma risk genes, only SIX6 was significantly associated with thinner retinal nerve fiber layer (RNFL), highlighting its role in glaucoma pathogenesis.

Li Xiaoli, Xie Jie, Zhang Liang, Cui Ying, Zhang Guanrong, Chen Xiangting et al.

OCTA revealed specific microvascular and neural parameters that correlate with diabetic retinopathy severity, offering potential for improved screening and staging.

Cheong Haris, Devalla Sripad Krishna, Pham Tan Hung, Zhang Liang, Tun Tin Aung, Wang Xiaofei et al.

DeshadowGAN, a deep learning tool, effectively removed blood vessel shadows from ONH OCT images, improving image quality. This enhances OCT analysis, potentially aiding diagnosis and prognosis in ocular pathologies.

Zhang Liang, Beotra Meghna R, Baskaran Mani, Tun Tin A, Wang Xiaofei, Perera Shamira A et al.

This study measured optic nerve head tissue stiffness in vivo, finding healthy prelamina significantly softer than in ocular hypertension, suggesting biomechanics may aid glaucoma management.

Qin Yong Jie, Chan Sun On, Lin Hong Liang, Zhang Yu Qiao, He Bei Ting, Zhang Liang et al.

This study found increased growth hormone-releasing hormone (GHRH) in proliferative diabetic retinopathy (PDR) fibrovascular membranes. This suggests GHRH contributes to PDR inflammation and could be a therapeutic target.

Tham Yih-Chung, Tao Yijin, Zhang Liang, Rim Tyler Hyung Taek, Thakur Sahil, Lim Zhi Wei et al.

This study found no overall link between kidney function and glaucoma in Asian populations, but a significant association emerged between lower kidney function and glaucoma in East Asian subgroups.

Cui Ying, Yang Xiaohong, Zhang Guanrong, Guo Haike, Zhang Min, Zhang Lixin et al.

This study found younger age, higher BMI, BP, FBG, LDL-C, and CCT correlated with higher IOP in Southern Chinese adults, with similar but distinct factors in diabetics, highlighting diverse risk profiles.

Cao Dan, Yang Dawei, Yu Honghua, Xie Jianteng, Zeng Yunkao, Wang Jun et al.

This study found optic nerve head microvascular changes and some RNFL thinning in pre-clinical diabetes. This suggests vascular defects may precede nerve damage in early diabetic retinopathy.

Jin Yuejiao, Wang Xiaofei, Zhang Liang, Jonas Jost B, Aung Tin, Schmetterer Leopold et al.

Using eye models, researchers found the ocular pulse, driven by choroidal expansion, deforms the optic nerve head, causing neural tissue shearing. This highlights biomechanical stress as a glaucoma factor.

Beotra Meghna R, Wang Xiaofei, Tun Tin A, Zhang Liang, Baskaran Mani, Aung Tin et al.

This study found that ocular hypertensive eyes exhibit lower lamina cribrosa strain than healthy eyes following acute IOP elevation, suggesting structural differences in glaucoma susceptibility.

Meng Qianli, Cui Ying, Zhang Min, Zhang Lixin, Zhang Liang, Zhang Jinxin et al.

The Dongguan Eye Study characterized eye disease prevalence and risk factors in 8952 rural southern Chinese adults. This provides vital epidemiological data for understanding eye health in urbanizing populations.

Zhang Liang, Albon Julie, Jones Hannah, Gouget Cecile L M, Ethier C Ross, Goh James C H et al.

Studying ONH biomechanics, researchers found that the peripapillary sclera's heterogeneous collagen fiber organization, especially moderate anisotropy, effectively limits lamina cribrosa strain, potentially reducing glaucoma-related damage.

Xu Fan, Zhang Liang, Li Min

This meta-analysis found pseudoexfoliation glaucoma is linked to elevated homocysteine and low folic acid, suggesting these biomarkers may be relevant for PEXG risk assessment.