Zhou Lei

Nusinovici Simon, Li Hengtong, Thakur Sahil, Baskaran Mani, Tham Yih-Chung, Zhou Lei et al.

This study found higher HDL3 cholesterol is causally linked to a decreased risk of primary open-angle glaucoma, suggesting cholesterol transport dysregulation may be a therapeutic target.

Nusinovici Simon, Zhang Liang, Chai Xiaoran, Zhou Lei, Tham Yih Chung, Vasseneix Caroline et al.

Machine learning identified modifiable and non-modifiable risk factors for major eye diseases. Key finding: POAG had the highest modifiable risk factor contribution (35%), with IOP and BMI being relevant.

Yun Juan, Xiao Tong, Zhou Lei, Beuerman Roger W, Li Juanjuan, Zhao Yuan et al.

This study found that ocular S100A8 levels correlate with recurrent autoimmune uveitis, promoting pathogenic T cells. Blocking S100A8 reduced recurrence, suggesting a new therapeutic target for this inflammatory eye condition.

Wong Tina T, Zhou Lei, Li Jing, Tong Louis, Zhao Shao Zhen, Li Xiao Rong et al.

Chronic glaucoma medication alters tear protein profiles, increasing inflammatory markers like S100-A8/A9, distinct from primary dry eye, which could guide specific treatment for ocular surface inflammation.

Theng Julian T S, Ti Seng-Ei, Zhou Lei, Lam Kwok-Wai, Chee Soon Phaik, Tan Donald

This study found an intraocular cyclosporine DDS safely delivered sustained, high drug levels to rabbit corneas for 3 months, suggesting potential for long-term corneal transplant rejection prevention.