Yu Marco

Xue Can Can, Li Hengtong, Chee Miao Li, Soh Zhi Da, Yu Marco, Lavanya Raghavan et al.

This study found metformin use is linked to a 19% lower glaucoma risk in diabetics, supported by meta-analysis and genetic evidence, suggesting its potential as a preventive therapy.

Soh Zhi-Da, Tan Mingrui, Lee Zann, Yu Marco, Thakur Sahil, Lavanya Raghavan et al.

Deep learning established normative anterior chamber dimensions, finding age/gender variations. Specific ACD/LV percentiles accurately detect primary angle closure disease, offering a simpler diagnostic tool for clinicians.

Umapathi Ruthra, Yu Marco, Cheng Ching-Yu, Najjar Raymond P, Husain Rahat, Ho Ching Lin et al.

This study identified three distinct angle closure subtypes using ASOCT. A spacious anterior chamber subtype was linked to stable PACS, while smaller dimensions were associated with glaucoma progression.

Soh Zhi-Da, Yu Marco, Chen Yanyan, Thakur Sahil, Lavanya Raghavan, Tham Yih Chung et al.

This study tracked GCIPL and RNFL thinning over 6 years, finding physiological age-related loss. Differentiating this from glaucoma progression is crucial for accurate diagnosis and monitoring.

Guo Philip Yawen, Zhang Xiulan, Li Fei, Lin Chen, Nguyen Anwell, Sakata Rei et al.

This study found that using normative angle measurement percentiles from OCT is more accurate than iris-trabecular contact for diagnosing gonioscopic angle closure, improving detection sensitivity and specificity.

Chan Poemen PuiMan, Shen Ruyue, Cheung Carol Y, Ling Anni, Yu Marco, Pang Chi-Pui et al.

This study found normal tension glaucoma (NTG) shows faster peripapillary vessel density loss than primary angle closure glaucoma (PACG), suggesting distinct vascular contributions to NTG progression.

Majithia Shivani, Chong Crystal Chun Yuen, Chee Miao Li, Yu Marco, Soh Zhi Da, Thakur Sahil et al.

This study found chronic kidney disease is consistently associated with thinning of retinal nerve and ganglion cell layers across diverse populations, suggesting kidney health impacts ocular nerve integrity.

Zhang Xiulan, Guo Philip Yawen, Lin Chen, Li Fei, Nguyen Anwell, Sakata Rei et al.

AS-OCT measured iris trabecular contact (ITC) extent, not gonioscopy, better predicts primary angle-closure/glaucoma risk, showing greater ITC correlates with higher disease odds.

Tan Shaoying, Yu Marco, Baig Nafees, Chan Poemen P, Tang Fang Yao, Cheung Carol Y et al.

This study found progressive primary angle closure glaucoma eyes had higher ultra-short-term IOP fluctuations during the first hour of sleep, suggesting this period is key for detecting progression risk.

Teo Zhen Ling, Soh Zhi Da, Tham Yih-Chung, Yu Marco, Chee Miao Li, Thakur Sahil et al.

This study found 3.50% of people developed primary angle-closure disease in 6 years. Older age, higher eye pressure, and shallower anterior chambers increased risk, guiding screening efforts.

Majithia Shivani, Tham Yih-Chung, Chong Crystal Chun Yuen, Yu Marco, Cheung Carol Y, Bikbov Mukharram M et al.

This study found Indian and Japanese eyes have thinner retinal nerve fiber layers than other Asians, highlighting the need for ethnic-specific normative databases for glaucoma diagnosis.

Soh Zhi, Yu Marco, Betzler Bjorn Kaijun, Majithia Shivani, Thakur Sahil, Tham Yih Chung et al.

This study found over half of global glaucoma cases are undetected, especially in Africa and Asia, highlighting an urgent need for improved screening to prevent irreversible blindness.

Thakur Sahil, Yu Marco, Tham Yih Chung, Majithia Shivani, Soh Zhi-Da, Fang Xiao Ling et al.

This study developed an algorithm to adjust OCT glaucoma parameters for poor signal strength, finding it significantly reduces bias, which can aid diagnosis and monitoring when high-quality scans are unobtainable.

Liu Chang, Nongpiur Monisha E, Cheng Ching-Yu, Khor Chiea-Chuen, Yu Marco, Husain Rahat et al.

Researchers found that a specific gene (EPDR1) and a higher genetic risk score are linked to more severe primary angle-closure glaucoma, potentially identifying individuals at risk for aggressive disease.

Lam Alexander K N, To Elaine, Weinreb Robert N, Yu Marco, Mak Heather, Lai Gilda et al.

Virtual reality simulations effectively identified vision-related disability in glaucoma patients, particularly in nighttime tasks, suggesting VR can augment clinical assessment of real-world visual impairment.

Zheng Feihui, Yu Marco, Leung Christopher Kai-Shun

This study found that superotemporal/inferotemporal RNFLT and MRW below the 5th percentile offer the best glaucoma detection. RNFLT showed higher sensitivity than MRW, improving early diagnosis.

Lin Chen, Mak Heather, Yu Marco, Leung Christopher Kai-Shun

This study found faster mean and peak retinal nerve fiber layer thinning rates, measured topographically, predict visual field worsening in glaucoma, aiding risk assessment.

Wu Zhongheng, Lin Chen, Crowther Michael, Mak Heather, Yu Marco, Leung Christopher K-S

Studying optic nerve head depth changes in glaucoma, researchers found faster posterior displacement of the lamina cribrosa and optic nerve head correlates with a higher risk of visual field progression, aiding patient management.

Yu Marco, Lin Chen, Weinreb Robert N, Lai Gilda, Chiu Vivian, Leung Christopher Kai-Shun

This study found progressive retinal nerve fiber layer thinning strongly predicts future visual field loss in glaucoma patients, highlighting its importance for early treatment decisions and as a clinical trial outcome.

Ye Cong, Yu Marco, Leung Christopher Kai-Shun

This study found that segmentation errors and retinal blood vessels significantly affect SD-OCT RNFL measurements, especially in advanced glaucoma, impacting diagnostic accuracy.

Tan Shaoying, Yu Marco, Baig Nafees, Chan Poemen Pui-man, Tang Fang Yao, Tham Clement C

This study found that specific patterns of circadian IOP fluctuation, measured by a contact lens sensor, differed significantly between progressive and stable primary angle-closure glaucoma eyes, suggesting large fluctuations may indicate progression risk.

Wu Zhongheng, Xu Guihua, Weinreb Robert N, Yu Marco, Leung Christopher K S

This study found glaucoma patients' optic nerve and lamina cribrosa surfaces can displace both posteriorly and anteriorly, with displacement magnitude linked to IOP and age, aiding in understanding disease progression.

Leung Christopher K S, Ye Cong, Weinreb Robert N, Yu Marco, Lai Gilda, Lam Dennis S

This study found age-related thinning impacts glaucoma progression detection, especially for macular measurements, and accounting for it reduces detected progression. RNFL and macular progression detection often disagree.

McKee Hamish, Ye Cong, Yu Marco, Liu Shu, Lam Dennis S C, Leung Christopher K S

Swept-source OCT effectively visualizes anterior chamber angle structures, especially the scleral spur. Visibility of Schwalbe's Line and Schlemm's Canal is lower, varying by scan density and quadrant, aiding glaucoma assessment.

Lai Isabel, Mak Heather, Lai Gilda, Yu Marco, Lam Dennis S C, Leung Christopher K S

Swept-source OCT accurately and reproducibly measures peripheral anterior synechia (PAS) area and degree in glaucoma patients. This offers a new tool for monitoring PAS progression and assessing angle-closure glaucoma risk.