Leung Christopher K S

Leung Christopher K S, Guo Philip Yawen, Lam Alexander K N

ROTA revealed papillomacular/papillofoveal bundle defects are common in early glaucoma, linked to central visual field loss. This challenges late-stage macular involvement, improving early detection.

Costa Vital P, Leung Christopher K S, Kook Michael S, Lin Shan C

Clear lens extraction effectively widens the angle and lowers eye pressure in angle closure, but requires experienced surgeons and long-term safety data are still needed.

Lu Shi Yao, Rong Shi Song, Wu Zhenggen, Huang Chukai, Matsushita Kenji, Ng Tsz Kin et al.

This study found a genetic marker (rs4236601) at the CAV1-CAV2 locus linked to normal-tension glaucoma in Chinese, but not Japanese, suggesting ethnic differences in disease risk.

Zheng Feihui, Wu Zhongheng, Leung Christopher K S

High myopia significantly increases indiscernible BMO, especially temporally, impacting glaucoma diagnosis by hindering accurate neuroretinal rim measurement.

Biswas Sayantan, Lin Chen, Leung Christopher K S

A myopic normative database improved specificity for detecting RNFL abnormalities in highly myopic eyes compared to standard databases, suggesting its inclusion in OCT devices for better glaucoma diagnosis.

Wu Zhongheng, Xu Guihua, Weinreb Robert N, Yu Marco, Leung Christopher K S

This study found glaucoma patients' optic nerve and lamina cribrosa surfaces can displace both posteriorly and anteriorly, with displacement magnitude linked to IOP and age, aiding in understanding disease progression.

Chan Poemen P M, Leung Christopher K S, Chiu Vivian, Gangwani Rita, Sharma Abhishek, So Sophie et al.

This study found that nearly half of low-risk ocular hypertension patients could safely reduce glaucoma medications for one year, yielding significant cost savings without significant IOP change.

Leung Christopher K S, Ye Cong, Weinreb Robert N, Yu Marco, Lai Gilda, Lam Dennis S

This study found age-related thinning impacts glaucoma progression detection, especially for macular measurements, and accounting for it reduces detected progression. RNFL and macular progression detection often disagree.

Xu Guihua, Weinreb Robert N, Leung Christopher K S

This study found that retinal nerve fiber layer (RNFL) thinning progresses more frequently and earlier than RNFL retardance reduction in glaucoma, suggesting thickness is a more sensitive progression marker.

McKee Hamish, Ye Cong, Yu Marco, Liu Shu, Lam Dennis S C, Leung Christopher K S

Swept-source OCT effectively visualizes anterior chamber angle structures, especially the scleral spur. Visibility of Schwalbe's Line and Schlemm's Canal is lower, varying by scan density and quadrant, aiding glaucoma assessment.

Ko Match W L, Leung Leo K K, Lam David C C, Leung Christopher K S

This study developed an indentation method to measure corneal stiffness in vivo. It found corneal stiffness is IOP-dependent, offering a new way to improve glaucoma diagnosis by personalizing IOP measurements.

Lai Isabel, Mak Heather, Lai Gilda, Yu Marco, Lam Dennis S C, Leung Christopher K S

Swept-source OCT accurately and reproducibly measures peripheral anterior synechia (PAS) area and degree in glaucoma patients. This offers a new tool for monitoring PAS progression and assessing angle-closure glaucoma risk.

Leung Christopher K S, Yu Marco, Weinreb Robert N, Ye Cong, Liu Shu, Lai Gilda et al.

This study found OCT-measured RNFL thickness naturally decreases with age, especially in superior/inferior quadrants. Clinically, this age-related thinning must be considered when monitoring glaucoma progression.

Ye Cong, To Elaine, Weinreb Robert N, Yu Marco, Liu Shu, Lam Dennis S C et al.

This study compared retinal nerve fiber layer defects using OCT and CSLO. It found OCT detected significantly larger and more extensive defects, indicating better sensitivity for early glaucoma detection.

Leung Christopher K S, Choi Nathan, Weinreb Robert N, Liu Shu, Ye Cong, Liu Lan et al.

SD-OCT revealed glaucoma-related RNFL defects are most common inferotemporally and superotemporally, expanding with disease progression. Measuring defect size offers a valuable new dimension for glaucoma evaluation.

Leung Christopher K S, Lam Shi, Weinreb Robert N, Liu Shu, Ye Cong, Liu Lan et al.

SD-OCT's RNFL deviation map analysis significantly improved glaucoma detection sensitivity compared to conventional circumpapillary measurements, offering better diagnostic performance for clinicians.

Wang Dan Yi, Fan Bao Jian, Chua John K H, Tam Pancy O S, Leung Christopher K S, Lam Dennis S C et al.

This study mapped a novel genetic locus for juvenile-onset primary open-angle glaucoma (JOAG) to chromosome 15q22-q24, offering a new target for understanding JOAG's genetic basis.

Leung Christopher K S, Chan Wai-Man, Ko Chun Yu, Chui Suk I, Woo Jackson, Tsang Moon-Kong et al.

OCT visualized dynamic anterior chamber angle changes in various angle-closure glaucomas, demonstrating how treatments like LPI/ALPI open the angle and normalize pressure, aiding understanding and management.

Leung Christopher K S, Chan Wai-Man, Yung Wing-Ho, Ng Alan C K, Woo Jackson, Tsang Moon-Kong et al.

This study compared OCT measurements for glaucoma detection. Peripapillary NFL thickness was superior to macular NFL and total macular thickness for detecting glaucoma and correlating with visual function.