Liu Shu

McKee Hamish, Ye Cong, Yu Marco, Liu Shu, Lam Dennis S C, Leung Christopher K S

Swept-source OCT effectively visualizes anterior chamber angle structures, especially the scleral spur. Visibility of Schwalbe's Line and Schlemm's Canal is lower, varying by scan density and quadrant, aiding glaucoma assessment.

Yang Bingzhi, Ye Cong, Yu Marco, Liu Shu, Lam Dennis Shun Chiu, Leung Christopher Kai-shun

This study found OCT and HRT optic disc measurements poorly agree, with OCT measuring smaller discs/rims. However, both instruments show high reproducibility, suggesting OCT may offer more precise monitoring.

Liu Shu, Li Zhi-wai, Weinreb Robert N, Xu Guihua, Lindsey James D, Ye Cong et al.

This study tracked retinal microglia in mice after optic nerve injury, finding microgliosis correlates with RGC loss. This imaging method could help assess glaucoma progression and treatment efficacy.

Leung Christopher K S, Yu Marco, Weinreb Robert N, Ye Cong, Liu Shu, Lai Gilda et al.

This study found OCT-measured RNFL thickness naturally decreases with age, especially in superior/inferior quadrants. Clinically, this age-related thinning must be considered when monitoring glaucoma progression.

Yu Marco, Weinreb Robert N, Yiu Cedric, Liu Shu, Or Ming Keung, Ye Cong et al.

This study found trend analysis generally outperforms event analysis for detecting progressive retinal nerve fiber layer loss in glaucoma, making it a more sensitive tool for earlier clinical detection.

Ye Cong, To Elaine, Weinreb Robert N, Yu Marco, Liu Shu, Lam Dennis S C et al.

This study compared retinal nerve fiber layer defects using OCT and CSLO. It found OCT detected significantly larger and more extensive defects, indicating better sensitivity for early glaucoma detection.

Liu Shu, Yu Marco, Ye Cong, Lam Dennis S C, Leung Christopher Kai-Shun

Swept-source OCT angle measurements are highly reproducible, yet variability is influenced by iris thickness, angle width, measurement location, and axial length, important for glaucoma assessment.

Li Zhi-wai, Liu Shu, Weinreb Robert N, Lindsey James D, Yu Marco, Liu Lan et al.

This study found RGC dendrites progressively shrink after 90-120 minutes of acute high IOP, but not shorter durations. This suggests dendritic shrinkage is an early, measurable sign of RGC damage in glaucoma.

Liu Shu, Lam Shi, Weinreb Robert N, Ye Cong, Cheung Carol Y, Lai Gilda et al.

This study compared SAP, FDT, and SWAP for glaucoma detection, finding FDT and SAP performed similarly and better than SWAP, especially for early disease, offering guidance for test selection.

Leung Christopher Kai-Shun, Chiu Vivian, Weinreb Robert N, Liu Shu, Ye Cong, Yu Marco et al.

This study compared SD-OCT and TD-OCT for detecting glaucoma progression. SD-OCT (Cirrus) detected significantly more retinal nerve fiber layer progression than TD-OCT (Stratus), indicating its superior clinical utility for monitoring glaucoma.

Leung Christopher Kai Shun, Liu Shu, Weinreb Robert N, Lai Gilda, Ye Cong, Cheung Carol Yim Lui et al.

This study found poor agreement between OCT, HRT, and visual field in detecting glaucoma progression, highlighting the need for individualized, multi-modal assessment due to high variability.

Leung Christopher Kai-Shun, Cheung Carol Yim-Lui, Weinreb Robert Neal, Liu Shu, Ye Cong, Lai Gilda et al.

This study found Stratus OCT's fast RNFL scan detects more glaucoma progression than the regular scan, suggesting it's preferable for monitoring nerve damage.

Leung Christopher Kai-shun, Weinreb Robert N, Li Zhi Wei, Liu Shu, Lindsey James D, Choi Nathan et al.

This study found that retinal ganglion cell (RGC) dendritic shrinkage precedes axon/cell body loss in mice after optic nerve crush. Larger dendrites predicted better RGC survival, suggesting a new way to track glaucoma progression and treatment efficacy.

Leung Christopher K S, Choi Nathan, Weinreb Robert N, Liu Shu, Ye Cong, Liu Lan et al.

SD-OCT revealed glaucoma-related RNFL defects are most common inferotemporally and superotemporally, expanding with disease progression. Measuring defect size offers a valuable new dimension for glaucoma evaluation.

Leung Christopher K S, Lam Shi, Weinreb Robert N, Liu Shu, Ye Cong, Liu Lan et al.

SD-OCT's RNFL deviation map analysis significantly improved glaucoma detection sensitivity compared to conventional circumpapillary measurements, offering better diagnostic performance for clinicians.

Cheung Carol Yim-lui, Liu Shu, Weinreb Robert N, Liu Jing, Li Haitao, Leung Dexter Yu-lung et al.

ASOCT revealed dynamic iris bowing patterns linked to anterior chamber angle width. Convex-to-convex bowing was common in narrow angles, suggesting iris dynamics are crucial for understanding angle closure risk.

Liu Shu, Li Haitao, Dorairaj Syril, Cheung Carol Yim Lui, Rousso Joe, Liebmann Jeffery et al.

This study found that scleral spur visibility on OCT correlates with anterior chamber angle width, highlighting its importance for assessing angle dimension in glaucoma.

Leung Christopher Kai-shun, Ye Cong, Weinreb Robert N, Cheung Carol Yim Lui, Qiu Quanliang, Liu Shu et al.

This study found Spectralis OCT retinal nerve fiber layer imaging had higher sensitivity than HRT optic disc measurements for glaucoma detection, suggesting superior diagnostic performance.

Leung Christopher Kai-shun, Cheung Carol Yim Lui, Weinreb Robert N, Qiu Kunliang, Liu Shu, Li Haitao et al.

This study showed OCT RNFL thinning rates vary in glaucoma, with faster loss in eyes having thicker baseline RNFL, aiding progression analysis.

Leung Christopher Kai-Shun, Cheung Carol Yim-Lui, Weinreb Robert N, Qiu Quanliang, Liu Shu, Li Haitao et al.

This study compared two OCT devices for glaucoma detection. Cirrus HD-OCT showed lower RNFL measurement variability than Stratus OCT, but both had comparable diagnostic performance and structure-function association. This suggests Cirrus offers more precise RNFL tracking.