Leung Christopher Kai-Shun

Wong Mandy Oi Man, Lai Isabel Sw, Chan Poemen Puiman, Chan Noel Cy, Chan Alison Yy, Lai Gilda Wk et al.

This study compared PSLT and SLT for glaucoma, finding PSLT was not superior to SLT in lowering eye pressure or safety, suggesting comparable clinical efficacy.

Wu Ken, Lin Chen, Lam Alexander Ka-Ngai, Chan Leo, Leung Christopher Kai-Shun

Combining wide-field RNFL-GCIPL thickness analysis improved glaucoma progression detection over RNFL or GCIPL alone, identifying more progressing eyes and predicting visual field loss risk more effectively.

Zheng Feihui, Yu Marco, Leung Christopher Kai-Shun

This study found that superotemporal/inferotemporal RNFLT and MRW below the 5th percentile offer the best glaucoma detection. RNFLT showed higher sensitivity than MRW, improving early diagnosis.

Wan Kelvin H, Lam Alexander K N, Leung Christopher Kai-Shun

This study found that standard OCT macular thickness measurements are superior to OCT-A vessel density for detecting glaucoma, suggesting OCT-A's limited role in macular glaucoma diagnosis.

Hou Hei Wan, Lin Chen, Leung Christopher Kai-Shun

This study found progressive macular GCIPL and parapapillary RNFL thinning are mutually predictive in glaucoma patients, and both strongly indicate visual field progression, aiding earlier detection of disease worsening.

Leung Christopher Kai-Shun

Lin Chen, Mak Heather, Yu Marco, Leung Christopher Kai-Shun

This study found faster mean and peak retinal nerve fiber layer thinning rates, measured topographically, predict visual field worsening in glaucoma, aiding risk assessment.

Yu Marco, Lin Chen, Weinreb Robert N, Lai Gilda, Chiu Vivian, Leung Christopher Kai-Shun

This study found progressive retinal nerve fiber layer thinning strongly predicts future visual field loss in glaucoma patients, highlighting its importance for early treatment decisions and as a clinical trial outcome.

Leung Christopher Kai-Shun

Advanced OCT imaging (SS-OCT, SD-OCT) significantly enhances anterior chamber angle and optic nerve head analysis, improving glaucoma detection and risk assessment for both angle-closure and open-angle types.

Ye Cong, Yu Marco, Leung Christopher Kai-Shun

This study found that segmentation errors and retinal blood vessels significantly affect SD-OCT RNFL measurements, especially in advanced glaucoma, impacting diagnostic accuracy.

Lindsey James D, Duong-Polk Karen X, Hammond Dustin, Chindasub Panida, Leung Christopher Kai-Shun, Weinreb Robert N

Brimonidine protected retinal ganglion cell dendrites from damage after optic nerve injury, but protection varied by RGC type. This suggests future glaucoma treatments may need RGC-specific approaches.

Mak Heather, Xu Guihua, Leung Christopher Kai-Shun

OCT showed iris volume decreases after dilation in all eyes, but less in smaller anterior chambers. Iris volume and chamber size are key determinants of angle width, impacting angle closure risk.

Leung Christopher Kai-Shun, Ye Cong, Weinreb Robert N

A Scheimpflug camera reliably measured corneal deformation (CDA). CDA, not CCT, was the main factor influencing Goldmann applanation tonometry errors, making it a crucial metric for accurate IOP.

Leung Christopher Kai-Shun, Yu Marco, Weinreb Robert N, Mak Heather Kayew, Lai Gilda, Ye Cong et al.

Myopia alters RNFL bundle distribution, causing more "abnormal" areas on OCT maps. Clinicians must consider this unique pattern when interpreting myopic RNFL scans for glaucoma.

Leung Christopher Kai-Shun, Yu Marco, Weinreb Robert N, Lai Gilda, Xu Guihua, Lam Dennis Shun-Chiu

This study found SD-OCT detects glaucoma progression via three RNFL patterns (widening, deepening, new defects), with widening most common. This helps clinicians monitor disease progression.

Ye Cong, Lam Dennis Shun, Leung Christopher Kai-Shun

This study found that averaging more OCT B-scans for RNFL measurement generally doesn't significantly change thickness values or variability, suggesting limited clinical impact for Spectralis OCT.

Yu Marco, Weinreb Robert N, Yiu Cedric, Liu Shu, Or Ming Keung, Ye Cong et al.

This study found trend analysis generally outperforms event analysis for detecting progressive retinal nerve fiber layer loss in glaucoma, making it a more sensitive tool for earlier clinical detection.

Liu Shu, Yu Marco, Ye Cong, Lam Dennis S C, Leung Christopher Kai-Shun

Swept-source OCT angle measurements are highly reproducible, yet variability is influenced by iris thickness, angle width, measurement location, and axial length, important for glaucoma assessment.

Qiu Kun Liang, Zhang Ming Zhi, Leung Christopher Kai-Shun, Zhang Ri Ping, Lu Xue Hui, Wang Geng et al.

In myopic eyes, Cirrus HD-OCT classified more RNFL measurements as abnormal than Stratus OCT, highlighting differences in diagnostic interpretation for glaucoma screening.

Liu Shu, Lam Shi, Weinreb Robert N, Ye Cong, Cheung Carol Y, Lai Gilda et al.

This study compared SAP, FDT, and SWAP for glaucoma detection, finding FDT and SAP performed similarly and better than SWAP, especially for early disease, offering guidance for test selection.

Leung Christopher Kai-Shun, Chiu Vivian, Weinreb Robert N, Liu Shu, Ye Cong, Yu Marco et al.

This study compared SD-OCT and TD-OCT for detecting glaucoma progression. SD-OCT (Cirrus) detected significantly more retinal nerve fiber layer progression than TD-OCT (Stratus), indicating its superior clinical utility for monitoring glaucoma.

Leung Christopher Kai-Shun, Cheung Carol Yim-Lui, Weinreb Robert Neal, Liu Shu, Ye Cong, Lai Gilda et al.

This study found Stratus OCT's fast RNFL scan detects more glaucoma progression than the regular scan, suggesting it's preferable for monitoring nerve damage.

Leung Christopher Kai-Shun, Cheung Carol Yim-Lui, Weinreb Robert N, Qiu Quanliang, Liu Shu, Li Haitao et al.

This study compared two OCT devices for glaucoma detection. Cirrus HD-OCT showed lower RNFL measurement variability than Stratus OCT, but both had comparable diagnostic performance and structure-function association. This suggests Cirrus offers more precise RNFL tracking.

Leung Christopher Kai-Shun, Mohamed Shaheeda, Leung King Sai, Cheung Carol Yim-Lui, Chan Sylvia Lai-wa, Cheng Daphne Ka-yee et al.

This study found retinal nerve fiber layer (RNFL) thickness decreases with increasing myopia. Clinically, this means OCT normative databases may be unreliable for myopic eyes, requiring refractive status consideration for glaucoma assessment.