Efficiency, Precision, Validity, and Reliability of GlauCAT-Asian Computerized Adaptive Tests in Measuring Glaucoma-Related Quality of Life.
Fenwick Eva K, Man Ryan E K, Lim Belicia, Baskaran Mani, Nongpiur Monisha, Sng Chelvin C A, Iyer Jayant Venkatramani, Husain Rahat, Perera Shamira, Wong Tina
AI Summary
GlauCAT-Asian efficiently and precisely measures glaucoma's patient-centered impact, showing promise as a clinical tool for monitoring disease progression and treatment effectiveness.
Abstract
Purpose
To determine the efficiency, precision, and agreement of GlauCAT-Asian and its corresponding validity and reliability.
Methods
In this cross-sectional study, 219 participants (mean ± standard deviation age, 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects were recruited from glaucoma clinics in Singapore. Participants answered seven computerized adaptive testing (CAT) evaluations (Ocular Comfort, Activity Limitation, Lighting, Mobility, Concerns, Psychosocial, Glaucoma Management) and underwent eye examinations. Efficiency (mean number of items required for each CAT and time taken for CAT versus full item banks [IBs]), agreement (concordance between CATs and full IB person measures, henceforth referred to as scores), and precision (standard error of measurement [SE]) were evaluated. Other validity and reliability metrics were also assessed.
Results
The mean number of items administered ranged from 9 (Mobility/Glaucoma Management) to 12 (Ocular Comfort). Compared to answering the full IBs, CATs provided an average time saving of 38.3% (range, 10% to 70.6% for Lighting and Activity Limitation, respectively). Agreement between scores obtained by CAT versus full IB was high (intracorrelation coefficient ≥0.75), as was precision of score estimates (mean SE range: 0.35 for Psychosocial to 0.29 for Mobility). Scores from Activity Limitation, Mobility, Lighting, and Concerns decreased significantly as glaucoma severity increased (criterion validity; P-trend <0.05). All tests displayed good convergent/divergent validity and test-retest reliability.
Conclusions
GlauCAT-Asian provides efficient, precise, accurate, valid, and reliable measurement of the patient-centered impact of glaucoma.
Translational relevance: GlauCAT-Asian may provide a valuable clinical tool for ophthalmologists to monitor impact of disease progression and the effectiveness of therapies.
MeSH Terms
Shields Classification
Key Concepts5
Compared to answering full item banks, GlauCAT-Asian computerized adaptive tests provided an average time saving of 38.3% (range, 10% for Lighting to 70.6% for Activity Limitation) in 219 participants (mean age 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects.
Agreement between scores obtained by GlauCAT-Asian computerized adaptive tests versus full item banks was high (intracorrelation coefficient ≥0.75), and precision of score estimates was also high (mean standard error range: 0.35 for Psychosocial to 0.29 for Mobility) in 219 participants (mean age 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects.
Scores from GlauCAT-Asian Activity Limitation, Mobility, Lighting, and Concerns computerized adaptive tests decreased significantly as glaucoma severity increased (criterion validity; P-trend <0.05) in 219 participants (mean age 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects.
All GlauCAT-Asian computerized adaptive tests displayed good convergent/divergent validity and test-retest reliability in 219 participants (mean age 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects.
The GlauCAT-Asian computerized adaptive tests administered a mean number of items ranging from 9 (Mobility/Glaucoma Management) to 12 (Ocular Comfort) in 219 participants (mean age 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects.
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