Medeiros Felipe A

Bhatnagar Anshul, Scherer Rafael, Samico Gustavo A, Muralidhar Rohit, Gutkind Naomi E, Palazoni Vitoria et al.

A medical LLM accurately identified glaucoma medication non-adherence, visit non-adherence, and family history from clinical notes, enabling large-scale research into these crucial risk factors.

Elhusseiny Abdelrahman M, Abboud Ibrahim, Almobayed Amr, Medeiros Felipe A

This study found chronic PDE-5 inhibitor use was associated with a lower risk of developing glaucoma suspect status or open-angle glaucoma in men, suggesting a potential protective effect.

DA Costa Douglas R, Medeiros Felipe A

Elhusseiny Abdelrahman M, Alzein Ahmad F, Medeiros Felipe A

Topical carbonic anhydrase inhibitors for glaucoma were linked to increased risk of new-onset depression, antidepressant use, and anxiety. Clinicians should monitor for these neuropsychiatric side effects.

Polski Ashley, Brintz Ben J, Hess Rachel, Kawamoto Kensaku, Medeiros Felipe A, Stein Joshua D et al.

Glaucoma treatment significantly accelerates at IOP ≥ 22 mmHg, suggesting clinicians' decisions are still influenced by this historical cutoff. This highlights a need for improved, continuous-risk-based clinical decision support.

da Costa Douglas R, Unyi Dániel, Scherer Rafael, Muralidhar Rohit, Ribeiro Monteiro Mario Luiz, Medeiros Felipe A

This study found a graph-based AI model (GIN) significantly outperforms traditional methods and other AI in detecting glaucomatous visual field defects, offering a more accurate and interpretable diagnostic tool.

Azizi Ali, da Costa Douglas R, Scherer Rafael, Malek Davina A, Samico Gustavo A, Medeiros Felipe A

This study found a deep learning model accurately estimated RNFL thickness from fundus photos, confirming age-related thinning and thinner RNFL in glaucoma, enabling scalable population-level screening.

Rabinowitz Aaron Samuel, Vilasboas-Campos Verônica, Filho Marcus Guerreiro, Medeiros Felipe A

This study found diffuse optic rim thinning at early visual field defect onset indicates significantly more retinal ganglion cell loss than localized thinning, highlighting the importance of structural assessment for early glaucoma.

Liu James C, Jammal Alessandro A, Scherer Rafael, da Costa Douglas R, Kass Michael, Gordon Mae et al.

Deep learning-predicted RNFL thickness from optic disc photos identified ocular hypertension patients at higher glaucoma risk and progression, offering a non-OCT risk assessment tool.

Kamdar Amey, Medeiros Felipe A, Swaminathan Swarup S

Longitudinal cup-to-disc ratio changes poorly predict glaucoma progression on OCT or visual fields. Clinicians should rely on comprehensive exams and ancillary testing for progression assessment.

Gameiro Gustavo Rosa, Jammal Alessandro A, Vilasboas-Campos Verônica, Wang Jianhua, Medeiros Felipe A

This study found fractal analysis of OCTA vessel density in glaucoma patients is highly repeatable in the macula and ONH, supporting its potential for monitoring vascular changes in glaucoma.

Malek Davina A, Diniz-Filho Alberto, Boer Erwin R, Medeiros Felipe A

Glaucoma patients with faster visual field loss showed worsening divided attention during driving simulation, indicating increased risk for driving performance decline.

Beniz Luiz A F, Jammal Alessandro A, Malek Davina A, Tseng Henry, Medeiros Felipe A

This study found the new Tono-Vera handheld tonometer strongly agreed with ORA measurements. This suggests it's a reliable, portable option for measuring intraocular pressure in glaucoma patients.

Medeiros Felipe A, Varma Achintya, Jammal Alessandro A, Tseng Henry, Scott William K

This study found faster epigenetic aging is linked to quicker glaucoma progression, suggesting biological age, measured by DNA methylation, could be a prognostic biomarker for optic nerve vulnerability.

Youssif Asmaa A, Onyekaba Ndidi-Amaka, Naithani Rizul, Abdelazeem Khaled, Fathalla Ahmed M, Abdel-Rhaman Mohamed S et al.

This study found higher BMI was linked to slower glaucoma progression, while tobacco and alcohol use had no significant effect on retinal nerve fiber layer loss. Underweight patients progressed faster.

Vilasboas-Campos Verônica, Jammal Alessandro A, Gracitelli Carolina P B, Gameiro Gustavo R, Costa Vital P, Medeiros Felipe A

This study found healthy eyes lose ~6769 retinal ganglion cells (0.6%) annually with age. This confirms age-related RGC decline, emphasizing its consideration when monitoring glaucoma progression.

Swaminathan Swarup S, Medeiros Felipe A

Shaheen Abdulla, Medeiros Felipe A, Swaminathan Swarup S

This study found higher social vulnerability (SVI/ADI) correlated with delayed glaucoma surgery, even after accounting for clinical factors. Recognizing these disparities is crucial for equitable glaucoma care.

Swaminathan Swarup S, Medeiros Felipe A, Gedde Steven J

This study found that higher social vulnerability, alongside age, IOP, and baseline severity, predicts severe visual impairment from glaucoma. Identifying vulnerable patients can help target interventions.

Mandal Sayan, Jammal Alessandro A, Malek Davina, Medeiros Felipe A

A deep learning model effectively distinguished glaucoma progression from age-related OCT changes, outperforming standard methods. This offers a promising tool for earlier, more accurate glaucoma management.

Swaminathan Swarup S, Jammal Alessandro A, Medeiros Felipe A, Gedde Steven J

This study found no significant difference in visual field progression between tube shunts and trabeculectomy. However, worse IOP control and older age were linked to faster visual field loss, highlighting the importance of consistent IOP reduction.

Beniz Luiz Arthur F, Campos Veronica P, Medeiros Felipe A

OCT is more accurate but costly, while disc photos are cheaper but subjective. AI integration, especially with objective OCT data, could optimize both for effective glaucoma screening.

Swaminathan Swarup S, Medeiros Felipe A

A nationwide study found older age, male sex, Black race, Hispanic ethnicity, non-commercial insurance, and higher socioeconomic vulnerability predicted worse open-angle glaucoma severity at diagnosis. This highlights the need for targeted screening.

Medeiros Felipe A, Malek Davina A, Tseng Henry, Swaminathan Swarup S, Boland Michael V, Friedman David S et al.

This study found intensive, clustered glaucoma testing over 6 months effectively identifies fast progressors. This method is valuable for clinical trials and short-term assessment of high-risk patients.

Swaminathan Swarup S, Berchuck Samuel I, Rao J Sunil, Medeiros Felipe A

This study found Linear Mixed Models, especially Student t-based, better estimate glaucoma progression from OCT RNFL data than conventional methods, enabling earlier detection of structural loss.