Aihara Makoto

Mataki Naomi, Mishima Koichi, Araie Makoto, Iwase Aiko, Murata Hiroshi, Otani Shinichiro et al.

Gonioscopy and UBM show significant disagreement in diagnosing occludable angles, with UBM both under- and over-diagnosing. Discrepancies relate to multiple anterior/posterior chamber factors, indicating neither method alone fully assesses angle closure.

Miki Atsuya, Araie Makoto, Leung Christopher Kai Shun, Nishigaki Masashi, Murata Hiroshi, Kikawa Tsutomu et al.

This study found that in glaucoma patients, the extent of retinal nerve fiber layer defects detected by ROTA was associated with optic nerve head gamma zone area, suggesting this structural change reflects axonal damage.

Shimizu Shota, Nemoto Hotaka, Ohata Shunichiro, Aihara Makoto, Honjo Megumi

MLT lowered IOP in rabbits by increasing outflow facility through transient MMP upregulation and ECM remodeling in the trabecular meshwork, elucidating its therapeutic mechanism for glaucoma.

Sato Minayo, Sakata Rei, Yamae Teruki, Suzuki Haruyuki, Nemoto Hotaka, Saito Hitomi et al.

PreserFlo MicroShunt safely and effectively reduced IOP and medication in Japanese glaucoma patients with prior surgery (filtration or ab interno/laser), offering a valuable option for complex cases.

Akiyama Kaho, Aoki Shuichiro, Shirato Shiroaki, Sakata Rei, Honjo Megumi, Aihara Makoto et al.

This study found eyes with unilateral peripapillary intrachoroidal cavitation (PICC) have distinct, elongated optic nerve head structures compared to fellow eyes, suggesting a strong link to myopia-related remodeling.

Sit Arthur J, Aihara Makoto, Khawaja Anthony P, Lin Shan C, Mansouri Kaweh, Miki Atsuya et al.

An expert group found lowering episcleral venous pressure (EVP), even modestly, may benefit glaucoma patients, especially those with low intraocular pressure or normal-tension glaucoma, offering individualized treatment.

Aihara Makoto, Lu Fenghe, Ikeda Toshihiro, Odani-Kawabata Noriko

This study found preservative-free and preserved omidenepag isopropyl drops are equally effective at lowering eye pressure. This offers a valuable preservative-free option for glaucoma/ocular hypertension patients, potentially reducing ocular surface irritation.

Guo Philip Yawen, Zhang Xiulan, Li Fei, Lin Chen, Nguyen Anwell, Sakata Rei et al.

This study found that using normative angle measurement percentiles from OCT is more accurate than iris-trabecular contact for diagnosing gonioscopic angle closure, improving detection sensitivity and specificity.

Tanihara Hidenobu, Yamamoto Tetsuya, Aihara Makoto, Koizumi Noriko, Fukushima Atsuki, Kawakita Koji et al.

This study found ripasudil-brimonidine fixed-dose combination significantly lowered intraocular pressure long-term, alone or with other glaucoma medications, offering a new treatment option despite common mild ocular side effects.

Shimizu Shota, Honjo Megumi, Liu Mengxuan, Aihara Makoto

Researchers developed a mouse model where autotaxin overexpression caused sustained high eye pressure via angle fibrosis, leading to retinal ganglion cell loss. This provides a new, inflammation-free model for glaucoma research.

Goto Hiroki, Honjo Megumi, Omoto Takashi, Aihara Makoto

Combined cataract surgery and trabeculotomy was effective, but long axial length eyes showed less IOP reduction and higher early IOP spikes, indicating a need for closer monitoring in these patients.

Fujita Asahi, Konishi Takaaki, Sakata Rei, Hashimoto Yohei, Yasunaga Hideo, Aihara Makoto

Prophylactic LPI for middle-aged PACS patients in Japan is cost-effective, preventing disease progression and blindness.

Aoyama Yurika, Sakata Rei, Fujishiro Takashi, Honjo Megumi, Shirato Shiroaki, Aihara Makoto

Ex-PRESS drainage achieved good IOP control in glaucoma patients, but late bleb needling significantly predicted poorer long-term IOP outcomes, suggesting caution with this intervention.

Asaoka Ryo, Sakata Rei, Yoshitomi Takeshi, Iwase Aiko, Matsumoto Chota, Higashide Tomomi et al.

This NTG study found different risk factors for progression in superior (IOP fluctuation) and inferior (BMI, myopia, cup-to-disc, disc hemorrhage) optic nerve halves, guiding tailored management.

Fujita Asahi, Hashimoto Yohei, Matsui Hiroki, Yasunaga Hideo, Aihara Makoto

This study found that maintaining a moderate BMI, eating breakfast, avoiding late dinners, limiting alcohol, and regular exercise are linked to a reduced glaucoma risk, highlighting lifestyle's role in prevention.

Fujita Asahi, Aoyama Yurika, Yamana Hayato, Konishi Takaaki, Hashimoto Yohei, Aihara Makoto et al.

Japanese claims data's diagnostic or antiglaucoma drug records accurately identify glaucoma patients, but subtype identification requires careful algorithm selection due to varying sensitivity/specificity.

Tanihara Hidenobu, Yamamoto Tetsuya, Aihara Makoto, Kawakita Koji, Kojima Satoshi, Kanazawa Mizuho et al.

This study found the ripasudil-brimonidine combination significantly lowers intraocular pressure more than either drug alone, offering a superior treatment option for glaucoma patients.

Zhang Xiulan, Guo Philip Yawen, Lin Chen, Li Fei, Nguyen Anwell, Sakata Rei et al.

AS-OCT measured iris trabecular contact (ITC) extent, not gonioscopy, better predicts primary angle-closure/glaucoma risk, showing greater ITC correlates with higher disease odds.

Ono Takashi, Iwasaki Takuya, Kawahara Kana, Agune Yuko, Mori Yosai, Nejima Ryohei et al.

Early blood pressure monitoring and control during cataract surgery effectively reduced perioperative hypertension, suggesting a simple, widely applicable clinical strategy.

Nemoto Hotaka, Honjo Megumi, Okamoto Michiaki, Sugimoto Koichiro, Aihara Makoto

MP-CPC in rabbits reduced IOP by increasing uveoscleral outflow, possibly via MMP upregulation, suggesting a mechanism for this glaucoma treatment.

Hashimoto Yohei, Kaneko Hidehiro, Okada Akira, Matsui Hiroki, Yasunaga Hideo, Aihara Makoto et al.

This study found that poor cardiovascular health metrics, especially nonideal blood pressure, significantly increase the risk of retinal vein occlusion, highlighting the importance of lifestyle modifications.

Yamagishi-Kimura Reiko, Honjo Megumi, Aihara Makoto

This study found a new glaucoma drug (sepetaprost) lowers eye pressure longer than latanoprost, likely by increasing fluid outflow through both FP and EP3 receptors, offering a potential long-acting treatment.

Liu Peng, Higashita Risa, Guo Philip Yawen, Okamoto Keiichiro, Li Fei, Nguyen Anwell et al.

Deep learning accurately localizes the scleral spur and measures anterior chamber angles from AS-OCT images with reproducibility comparable to manual methods, offering a reliable automated tool for glaucoma assessment.

Aoyama Yurika, Sakata Rei, Fujishiro Takashi, Honjo Megumi, Shirato Shiroaki, Aihara Makoto

Ex-PRESS glaucoma surgery caused a small, non-problematic CECD decrease (1.8%/year) over 3 years, but patients with low preoperative CECD need regular monitoring for potential future issues.

Nakajima Kosuke, Sakata Rei, Ueda Koji, Fujita Asahi, Fujishiro Takashi, Honjo Megumi et al.

Trabeculectomy in NTG patients with low preoperative IOP significantly slowed central visual field deterioration, suggesting it can preserve central vision even in these challenging cases.