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Lu Fenghe

5 articles in GJC

5 articles in GJC

1.

Bioequivalence of Preservative-Free and Preserved Omidenepag Isopropyl 0.002% Ophthalmic Solutions in Patients With Primary Open Angle Glaucoma or Ocular Hypertension: Phase 3 DAISY Study.

Aihara Makoto, Lu Fenghe, Ikeda Toshihiro, Odani-Kawabata Noriko

J GlaucomaJan 20250 citationsRandomized Controlled Trial

This study found preservative-free and preserved omidenepag isopropyl drops are equally effective at lowering eye pressure. This offers a valuable preservative-free option for glaucoma/ocular hypertension patients, potentially reducing ocular surface irritation.

2.

Omidenepag Isopropyl Versus Timolol in Patients With Glaucoma or Ocular Hypertension: Two Randomized Phase 3 Trials (SPECTRUM 4 and 3).

Bacharach Jason, Brubaker Jacob W, Evans David G, Lu Fenghe, Odani-Kawabata Noriko, Yamabe Takaharu et al.

Am J OphthalmolFeb 202411 citationsRandomized Controlled Trial

Two studies found omidenepag isopropyl effectively lowers IOP in glaucoma/OHT, non-inferior to timolol over 3 months, with sustained 12-month efficacy, offering a new treatment option.

3.

A Randomized Phase 2 Trial Comparing Omidenepag Isopropyl 0.002% Once and Twice Daily in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension (SPECTRUM-6).

Olander Kenneth W, Sato Michelle A, Abrams Marc A, Jerkins Gary W, Lu Fenghe, Dinh Phillip et al.

J GlaucomaJun 202116 citationsRandomized Controlled Trial

Omidenepag isopropyl for glaucoma showed similar IOP reduction with once-daily (QD) versus twice-daily (BID) dosing. However, BID dosing had significantly more adverse events, making QD the preferred regimen for future study.

5.

Phase 2, Randomized, Dose-finding Studies of Omidenepag Isopropyl, a Selective EP2 Agonist, in Patients With Primary Open-angle Glaucoma or Ocular Hypertension.

Aihara Makoto, Lu Fenghe, Kawata Hisashi, Iwata Akihiro, Liu Kathy, Odani-Kawabata Noriko et al.

J GlaucomaMay 20190 citationsRandomized Controlled Trial

Omidenepag isopropyl effectively lowered IOP in glaucoma/ocular hypertension patients, with 0.002% identified as the optimal, well-tolerated dose for further study, offering a new potential treatment option.

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