Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study.
Guo Congcong, Zhao Zhenni, Zhang Dandan, Liu Jiafan, Li Jianlong, Zhang Jiamin, Sun Nannan, Chen Denghui, Zhang Miao, Fan Zhigang
AI Summary
This study found nanophthalmic eyes with angle-closure glaucoma have narrower anterior segments, larger, forward-shifted lenses, and higher malignant glaucoma risk than primary angle-closure glaucoma.
Abstract
Purpose
We compare anterior segment parameters and the risk of malignant glaucoma between nanophthalmos with secondary chronic angle closure glaucoma (NSCACG) and chronic primary angle-closure glaucoma (CPACG).
Methods
This retrospective case-control study included 32 NSCACG (32 eyes) and 36 CPACG (36 eyes) patients. Anterior segment parameters, including anterior chamber depth (ACD) and width (ACW), pupil diameter (PD), lens vault (LV), ciliary process-ciliary process distance (CCD), angle opening distance500 (AOD500), trabecular-iris angle (TIA), trabecular-ciliary processes distance (TCPD), ciliary body max thickness (CBMT), iris convexity (IC), peripheral iris thickness (PIT), iris-zonule distance (IZD), trabecular ciliary process angle (TCPA), and anterior vault (AV), were measured by ultrasound biomicroscopy. A-scan ultrasonography measurements, including lens thickness (LT) and axial length (AL), also were reviewed.
Results
ACD, ACW, CCD, TCPD, and AL were smaller, whereas the LV, LT/AL, LV/LT, LV/ACD, LT/ACD, LV/AV, and AV/AL were larger in NSCACG compared to CPACG eyes (all Bonferroni-corrected P < 0.05). Eyes with NSCACG had a higher risk of malignant glaucoma postoperatively than eyes with CPACG (P = 0.018).
Conclusions
Characterized by narrower anterior segment, forward movement of larger lens, more anteriorly rotated ciliary bodies, and smaller CCD, NSCACG eyes have a higher risk of malignant glaucoma than CPACG eyes.
MeSH Terms
Shields Classification
Key Concepts4
Anterior chamber depth (ACD), anterior chamber width (ACW), ciliary process-ciliary process distance (CCD), trabecular-ciliary processes distance (TCPD), and axial length (AL) were smaller in nanophthalmos with secondary chronic angle closure glaucoma (NSCACG) compared to chronic primary angle-closure glaucoma (CPACG) eyes (all Bonferroni-corrected P < 0.05).
Lens vault (LV), lens thickness/axial length (LT/AL), lens vault/lens thickness (LV/LT), lens vault/anterior chamber depth (LV/ACD), lens thickness/anterior chamber depth (LT/ACD), lens vault/anterior vault (LV/AV), and anterior vault/axial length (AV/AL) were larger in nanophthalmos with secondary chronic angle closure glaucoma (NSCACG) compared to chronic primary angle-closure glaucoma (CPACG) eyes (all Bonferroni-corrected P < 0.05).
Eyes with nanophthalmos with secondary chronic angle closure glaucoma (NSCACG) had a higher risk of malignant glaucoma postoperatively than eyes with chronic primary angle-closure glaucoma (CPACG) (P = 0.018).
Nanophthalmos with secondary chronic angle closure glaucoma (NSCACG) eyes are characterized by a narrower anterior segment, forward movement of a larger lens, more anteriorly rotated ciliary bodies, and a smaller ciliary process-ciliary process distance (CCD) compared to chronic primary angle-closure glaucoma (CPACG) eyes.
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