Topographic correlation between macular superficial microvessel density and ganglion cell-inner plexiform layer thickness in glaucoma-suspect and early normal-tension glaucoma.
Kim Jin-Soo, Kim Young Kook, Baek Sung Uk, Ha Ahnul, Kim Yong Woo, Jeoung Jin Wook, Park Ki Ho
AI Summary
Macular microvessel density correlates topographically with ganglion cell loss in early glaucoma, suggesting its potential for diagnosing and monitoring early disease.
Abstract
Background/aims: To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG).
Methods
A total of 86 eyes of 86 patients with early NTG (standard automated perimetry mean deviation >-5.5 decibels) and a total of 25 eyes of 25 patients with GS were retrospectively reviewed. All of the subjects underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan. On the OCTA scan images, macular SMD was analysed by customised software.
Results
In GS and patients with early NTG, macular GCIPL thickness showed significant correlations with macular SMD in the superotemporal (ST), inferotemporal (IT) and inferoinferior (II) sectors ( r = 0.191, 0.373 and 0.346 for ST, IT and II sector, respectively). Additionally, circumpapillary retinal nerve fibre layer (RNFL) thickness and macular SMD showed significant correlations between the ST sector of the macula and the 1, 9 clock-hour peripapillary regions and between the IT and II sectors of the macula and the 6, 7, 8 clock-hour peripapillary regions. The IT sector macular SMD showed fair diagnostic power (area under the receiver operating characteristic curve [AUROC] = 0.758) and showed high diagnostic power when combined with IT sector macular GCIPL thickness (AUROC=0.954).
Conclusions
Sectoral macular SMD showed topographic correlations with macular GCIPL thickness and circumpapillary RNFL thickness in patients with GS and early-stage NTG. Macular SMD analysis is potentially useful in the clinical evaluation of early glaucoma.
MeSH Terms
Shields Classification
Key Concepts6
In eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG), macular ganglion cell-inner plexiform layer (GCIPL) thickness showed significant correlations with macular superficial microvessel density (SMD) in the superotemporal (ST), inferotemporal (IT) and inferoinferior (II) sectors (r = 0.191 for ST, r = 0.373 for IT, and r = 0.346 for II sector, respectively).
In eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG), circumpapillary retinal nerve fibre layer (RNFL) thickness and macular superficial microvessel density (SMD) showed significant correlations between the ST sector of the macula and the 1, 9 clock-hour peripapillary regions.
In eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG), circumpapillary retinal nerve fibre layer (RNFL) thickness and macular superficial microvessel density (SMD) showed significant correlations between the IT and II sectors of the macula and the 6, 7, 8 clock-hour peripapillary regions.
In eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG), the inferotemporal (IT) sector macular superficial microvessel density (SMD) showed fair diagnostic power (area under the receiver operating characteristic curve [AUROC] = 0.758).
In eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG), the inferotemporal (IT) sector macular superficial microvessel density (SMD) showed high diagnostic power when combined with IT sector macular ganglion cell-inner plexiform layer (GCIPL) thickness (AUROC = 0.954).
Macular superficial microvessel density (SMD) analysis is potentially useful in the clinical evaluation of early glaucoma in patients with glaucoma-suspect and early-stage normal-tension glaucoma.
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