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Section II · Clinical Forms
Shields' Textbook of Glaucoma, 6th edition
Showing 1–20 of 1,328 articles
Elhusseiny Abdelrahman M, Abboud Ibrahim, Almobayed Amr et al.
This study found chronic PDE-5 inhibitor use was associated with a lower risk of developing glaucoma suspect status or open-angle glaucoma in men, suggesting a potential protective effect.
Ntonti Panagiota, Coleman Anne L, Wilson Masao Roy et al.
This 12-year study identified high IOP, pseudoexfoliation, family history, and heart attack history as key risk factors for developing open-angle glaucoma, while increased sleep and alcohol were protective.
Kolovos Antonia, Aung Tin, Khawaja Anthony P et al.
Polygenic risk scores (PRS) for glaucoma show promise in improving early diagnosis and predicting disease course, offering personalized risk assessment to enhance clinical management.
Matsuo Masato, Sharpe Glen P, Hutchison Donna M et al.
This study found normal aging causes about half of the retinal nerve fiber layer thinning observed in treated glaucoma patients, helping distinguish age-related changes from disease progression.
Soltani Ghazaleh, Nishida Takashi, Moghimi Sasan et al.
In glaucoma suspects, microvascular dropout and β-zone PPA progression were independently linked to optic disc structural progression, highlighting these as early markers for timely intervention.
DA Costa Douglas R, Medeiros Felipe A
Awasthi Dileep Kumar, Gupta Vikas, Jain Subnesh Kumar
Nomoto Hiroki, Matsumoto Chota, Okuyama Sachiko et al.
Zhang Yue, Padhee Swati, Yuhas Phillip T et al.
A novel AI model accurately predicted ocular stiffness from ORA waveforms, improving keratoconus detection. This expands ORA's utility for biomechanical assessment and diagnosis in clinical settings.
Lee Jaekyoung, Kim Young Kook, Park Ki Ho et al.
Over 10 years, 35.5% of preperimetric glaucoma patients converted to open-angle glaucoma. Disc hemorrhage and insufficient IOP reduction predicted conversion, emphasizing long-term monitoring and risk factor management.
Canleblebici Mehmet, Balbaba Mehmet
Taylor Kirby, Mosenia Arman, Bowden Eileen C
Recent trials (LiGHT, ZAP, EAGLE, TAGS, PTVT) show laser and surgical advancements are reshaping glaucoma management, offering tailored first-line and advanced treatment options for better patient outcomes.
Tan Jeremy C K, Phu Jack, Bell Katharina et al.
Initial visual field defect cluster size and volume predict repeatable glaucoma defects, helping identify eyes at higher risk for true progression and guiding clinical management.
Zhao Dongyang, Fang Huihui, Gao Qi et al.
This study developed a multi-modal AI system for glaucoma grading, showing significantly improved accuracy by combining multiple eye scans, offering a more precise diagnostic tool for clinicians.
Chen Daniel X, Tang Kayen, Ding Leona et al.
This study found SPECTRALIS GMPE and SGM modules, despite high correlation, yield significantly different RNFL thickness measurements. Clinicians must consider these differences when interpreting or transitioning between modules for glaucoma management.
Majid Iyad, Zebardast Nazlee, Wang Mengyu
AI translated underutilized SLO images into synthetic color fundus photos. Using these synthetic images with real ones significantly improved deep learning glaucoma detection, enhancing screening accuracy.
Tan Jeremy C K, Crowston Jonathan, Bell Katharina et al.
Frontloading two visual field tests per visit decreases longitudinal variability in glaucoma monitoring, potentially improving detection of real change and meeting testing frequency recommendations.
Lee Lok Hin, Xie Yangyiran, Pan Annabelle et al.
This study found rapid glaucoma progression predicted aggressive treatment, but most rapidly progressing patients didn't receive it, often due to clinician choice, not functional decline or patient preference, with socioeconomic factors also impacting care.
Xu Zhenyi, Lin Ruilang, Wang Xiaojun et al.
This study found physical frailty increases irreversible eye disease risk, particularly with higher genetic predisposition. Managing frailty may help prevent conditions like glaucoma, diabetic retinopathy, and AMD.
Pham Vincent Q, Nishida Takashi, Moghimi Sasan et al.
Initial OCT-measured cpRNFL loss rates predict future glaucoma progression, with faster early loss indicating higher risk. This helps clinicians predict disease course and guide patient management.
In the glaucoma group, cumulative exposure to relative humidity of 61-69% and 78-89% over lag 0-6 days was significantly associated with reduced intraocular pressure (IOP).
In the glaucoma group, cumulative exposure to relative humidity of 79-88.5% over lag 0-13 days was significantly associated with reduced intraocular pressure (IOP).
In the glaucoma group, cumulative exposure to very high relative humidity (97-98%) over lag 0-6 days was significantly associated with increased intraocular pressure (IOP).
An association was reported between asymmetrical normal tension glaucoma (NTG) with obstructive sleep apnoea (OSA; apnoea-hypopnoea-index ≥5) in habitual side-sleepers.
In worse eyes of NTG-OSA patients, mean blur rate for tissue (MT) was less in the lower lateral decubitus (LD) position (9.00 ± 2.07 au) compared to the upper LD position (9.27 ± 1.97 au; P = 0.037) and supine position (9.61 ± 1.95 au; P = 0.011), suggesting reduced optic nerve head blood flow velocity in the lower LD position.
Among NTG-OSA participants who slept with the worse eye lower, mean blur rates for vascular (MV), tissue (MT), and entire area (MA) were less in the worse eyes in both lower and upper lateral decubitus (LD) positions versus the fellow eye (all P < 0.05), but not in the supine position.
Among NTG-OSA participants who slept with the worse eye upper, mean blur rates for vascular (MV) and tissue (MT) were less in the worse eyes only in the lower lateral decubitus (LD) position (both P < 0.05), with no differences in other positions.
Anterior scleral thickness at 0-3mm from the scleral spur (AST0) was significantly lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls in both nasal and temporal quadrants (all p < 0.001).
Schlemm's canal area (SCA) and scleral spur length (SSL) were significantly lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls in both nasal and temporal quadrants (all p < 0.001).
For anterior scleral thickness at 3mm from the scleral spur (AST3), temporal values were lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls (p < 0.001), while nasal AST3 showed no significant group difference.
In 2019, glaucoma comprised 11.7% of the total vision impairment burden among individuals with diabetes in Taiwan.
Higher serum Klotho levels were positively associated with glaucoma risk (odds ratio [OR] = 1.05 per 100 pg/mL increase; 95% confidence interval [CI], 1.01-1.09; P = 0.006) in 2952 participants aged 40 years and older from the 2007-2008 National Health and Nutrition Examination Survey.