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Section II · Clinical Forms

Chapter 9: Clinical Epidemiology of Glaucoma

Shields' Textbook of Glaucoma, 6th edition

Showing 1–20 of 4,354 articles

12.
Systematic Review

Spherical Equivalent Refraction Versus Axial Length for Monitoring Childhood Myopia and Estimating Disease Risk: A Systematic Review and Meta-Analysis.

Clark Robert A, Wong Rupa K

Am J OphthalmolMar 2026

This study found that while axial length (AL) thresholds identify very long eyes at high retinal risk, spherical equivalent refraction (SER) better predicts cataract, glaucoma, and general myopic pathology, suggesting SER should be the primary monitoring metric.

16.
Observational Study

Revised Swedish visual field standards for a driver's licence: Threshold perimetry as a predictor of eligibility according to the current Swedish and current Norwegian suprathreshold standards.

Saadi Wid, Bro Tomas, Sagerfors Susanna

Acta OphthalmolMar 2026

This study found threshold perimetry (≥10dB within 20°) can predict driver's license visual field eligibility (Swedish/Norwegian standards) with good sensitivity. More people meet the current Swedish standard than the former.

18.
Observational Study

Iberian Registry of Ocular Syphilis (IBERSOS) report 1: epidemiology, clinical spectrum and treatment outcomes of ocular syphilis in the Iberian Peninsula.

Vicente-Antolín Marta, González-López Julio José, Pardiñas Baron Nieves et al.

Br J OphthalmolMar 2026

Iberian ocular syphilis frequently affects the posterior segment, with most patients achieving good visual and serological outcomes with standard treatment, emphasizing early diagnosis in high-risk groups.

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The use of any postmenopausal hormonal replacement therapy (HRT) was associated with an increased risk for the development of glaucoma in 6576 postmenopausal women aged ≥50 years in Finland, after adjustment for confounding factors.

EpidemiologyCohortPopulation-based historic cohort studyn=1096 cases and 5480 age-matched controls (total 6576 females)

In postmenopausal women aged ≥50 years in Finland, estrogen-only hormonal replacement therapy (HRT) users had an increased risk of glaucoma (adjusted OR, 1.33 [95% CI, 1.17-1.52]) in a nested-case-control study involving 1096 cases and 5480 age-matched controls.

EpidemiologyCohortNested-case-control studyn=1096 cases and 5480 age-matched controls

In postmenopausal women aged ≥50 years in Finland, progestogen-only hormonal replacement therapy (HRT) users had an increased risk of glaucoma (adjusted OR, 1.25 [95% CI, 1.02-1.53]) in a nested-case-control study involving 1096 cases and 5480 age-matched controls.

EpidemiologyCohortNested-case-control studyn=1096 cases and 5480 age-matched controls

In postmenopausal women aged ≥50 years in Finland, combined estrogen-progesterone hormonal replacement therapy (HRT) users had an increased risk of glaucoma (adjusted OR, 1.19 [95% CI, 1.01-1.39]) in a nested-case-control study involving 1096 cases and 5480 age-matched controls.

EpidemiologyCohortNested-case-control studyn=1096 cases and 5480 age-matched controls

In the primary open-angle glaucoma (POAG) subgroup of postmenopausal women aged ≥50 years in Finland, estrogen-only hormonal replacement therapy (HRT) users showed a significant increased risk (adjusted OR, 1.31 [95% CI, 1.10-1.56]) in a nested-case-control study involving 1096 cases and 5480 age-matched controls.

EpidemiologyCohortNested-case-control studyn=1096 cases and 5480 age-matched controls

In a multicenter, retrospective cohort study of male adults aged ≥40 years with erectile dysfunction, the development of glaucoma suspect (GS) status was less frequent among phosphodiesterase type-5 inhibitor (PDE-5i) users at 1 year (6.49% vs 9.73%, p<0.01), 2 years (9.27% vs 10.86%, p<0.01), and 3 years (11.17% vs 12.06%, p=0.01) after propensity score matching.

PrognosisCohortRetrospective Cohort Studyn=40,676 men received PDE-5i therapy and 32,415 had no exposure before matching

In a multicenter, retrospective cohort study of male adults aged ≥40 years with erectile dysfunction, the development of open-angle glaucoma (OAG) was less frequent among phosphodiesterase type-5 inhibitor (PDE-5i) users at 1 year (2.13% vs 3.22%, p<0.01), 2 years (3.00% vs 3.80%, p<0.01), and 3 years (3.88% vs 4.28%, p=0.04) after propensity score matching.

PrognosisCohortRetrospective Cohort Studyn=40,676 men received PDE-5i therapy and 32,415 had no exposure before matching

Cox proportional models in a multicenter, retrospective cohort study of male adults aged ≥40 years with erectile dysfunction demonstrated reduced hazards for glaucoma suspect (GS) at 1 year (aHR 0.78; 95% CI, 0.75-0.81; p<0.01), 2 years (0.89; 0.86-0.93; p<0.01), and 3 years (0.94; 0.90-0.97; p=0.01) with phosphodiesterase type-5 inhibitor (PDE-5i) use.

PrognosisCohortRetrospective Cohort Studyn=40,676 men received PDE-5i therapy and 32,415 had no exposure before matching

Cox proportional models in a multicenter, retrospective cohort study of male adults aged ≥40 years with erectile dysfunction demonstrated reduced hazards for open-angle glaucoma (OAG) at 1 year (aHR 0.76; 95% CI, 0.71-0.81; p<0.01), 2 years (0.79; 0.75-0.83; p<0.01), and 3 years (0.84; 0.79-0.88; p=0.01) with phosphodiesterase type-5 inhibitor (PDE-5i) use.

PrognosisCohortRetrospective Cohort Studyn=40,676 men received PDE-5i therapy and 32,415 had no exposure before matching

Chronic phosphodiesterase type-5 inhibitor (PDE-5i) use was associated with a lower hazard of developing glaucoma suspect (GS) and open-angle glaucoma (OAG) over 1-, 2-, and 3-years of follow-up in men with erectile dysfunction.

PrognosisCohortRetrospective Cohort Studyn=Male adults aged ≥40 years with ED

Data for 55 patients (median [IQR] age at diagnosis for 45 patients, 24 [8-51] years; 33 male [67%]) from 37 families with ACO2 variants were compiled in a retrospective case series.

EpidemiologyCase seriesRetrospective case seriesn=55 patients from 37 families

In a prospective-longitudinal population-based study of 826 elderly white subjects, baseline pseudoexfoliation (PEX) was associated with incident open-angle glaucoma (p=0.002).

PrognosisCohortProspective Cohortn=826 elderly white subjects