Chapter 7: Classification of the Glaucomas

Lawrence Alexandra L, Savino Peter J, Danesh-Meyer Helen V

This review helps differentiate NAION from its mimics, emphasizing key features and red flags to prevent misdiagnosis and guide appropriate, timely treatment for sudden vision loss.

Lanza Michele, Boccia Rosa, Scutifero Marianna et al.

Lum Flora

Cohen Samuel A, Kalavar Meghana, Sridhar Jayanth

This study synthesized surgical advances for Marfan ocular complications, finding improved outcomes but persistent high risks. Individualized planning and long-term surveillance are crucial for these patients.

Spaide Richard F

SS-OCT revealed optic disc pit maculopathy involves a deep optic nerve "complex" of laminar defects, cavitations, and diverse fluid pathways, improving diagnosis and guiding treatment.

Beecher Mark, Rana Khizar, Gowda Raghu et al.

Radiotherapy for eye/orbital conditions, despite advances, causes various vision-threatening complications like neovascular glaucoma, radiation retinopathy, and optic neuropathy, varying by treatment type and patient factors.

Kountouras Jannis, Zavos Christos, Polyzos Stergios A et al.

Yehezkeli Veronika, Kim Janice J, Velez Federico G et al.

This study found Sagging Eye Syndrome (SES) in older adults is linked to advanced age at onset, and in women, lower BMI and osteopenia, suggesting specific systemic factors may contribute to its development.

Fang Zige, Zhang Xiulan

Chan Jun He, Yeo Brian Sheng Yep, Lau Wai Kit et al.

This meta-analysis found short-term CPAP in OSA patients significantly increased IOP, but long-term use showed minimal effect. Clinically, caution is advised for CPAP use, especially in glaucoma patients.

Liu Yong, Gong Di, Dang Kuanrong et al.

This meta-analysis found next-generation sequencing identified genetic causes in 26.2% of primary glaucoma cases, with subtype-specific strategies (e.g., WES for PCG, panel for PACG) proving most effective for diagnosis.

Deubel Carolin, Walz Wolfgang, Petrak Michael et al.

The PAUL Glaucoma Implant effectively lowered IOP in neovascular glaucoma, showing significant reduction but challenging sustained very low pressures, offering a viable option for complex cases.

Tinker Rory J, Smith Logan M, Bastarache Lisa A et al.

The UDN successfully diagnosed 40.2% of complex ocular cases using genomic tools, significantly higher than non-ocular cases, highlighting its value for ophthalmologists solving challenging diagnostic mysteries.

Gupta Preeti, Thakur Sahil, Wong Chiew Meng Johnny et al.

Glaucoma affects 5.1% of older Singaporeans, with higher rates in Malays/Indians and increasing prevalence projected. This highlights the urgent need for targeted screening and early intervention strategies, especially for specific ethnic groups.

Kang Jae H, Wu Zhiyu, Yu Megan et al.

This study found later menarche age was linked to lower exfoliation glaucoma risk. Surgical menopause also reduced risk in genetically susceptible women, suggesting hormonal influences on this glaucoma type.

Yu Xiaowei, Zhao Hanxue, Gao Yan et al.

This study found genetic variants (PRSS56, MFRP, MYRF, TMEM98) in Chinese nanophthalmos patients with angle-closure glaucoma. These genes are linked to distinct eye structures and faster glaucoma progression, underscoring the need for early intervention.

Patel Anamika, Kelgaonkar Anup, Pathengay Avinash

Tao Brendan K, Wong Madeleine, Shunmugam Maheshver et al.

This meta-analysis found retinitis pigmentosa is associated with a doubled risk of angle closure glaucoma. RP patients may benefit from enhanced ACG monitoring due to this increased risk.

Negretti Guy S, Ushakova Tatiana, Yuri Serov et al.

This study found retinoblastoma eyes with neovascular glaucoma (NVG) have significantly higher odds of high-risk histopathology and metastatic disease, highlighting NVG as a crucial prognostic indicator.