Quantitative Analysis of Retinal Nerve Fiber Layer Thickness Using SPECTRALIS Glaucoma Module Premium Edition and SPECTRALIS Standard Glaucoma Module.
Chen Daniel X, Tang Kayen, Ding Leona, Chen Andrew, Chen Philip P, Bojikian Karine D
AI Summary
This study found SPECTRALIS GMPE and SGM modules, despite high correlation, yield significantly different RNFL thickness measurements. Clinicians must consider these differences when interpreting or transitioning between modules for glaucoma management.
Abstract
Purpose
To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness measured by SPECTRALIS Glaucoma Module Premium Edition (GMPE) and SPECTRALIS Standard Glaucoma Module (SGM).
Methods
This was a cross-sectional study of glaucoma and glaucoma suspect patients from an academic center between May and October 2023. Peripapillary RNFL thickness was measured using GMPE and SGM on the same day; only scans with good centration and reliable segmentation in both modalities were analyzed.
Results
Of 1277 eyes (665 patients) reviewed, 766 eyes (465 patients) met inclusion criteria. Global and sectoral RNFL thicknesses were highly correlated between GMPE and SGM (r ≥ 0.844; ICC ≥ 0.706; P < 0.001 for all); however, global and sectoral RNFL thicknesses between the modules were significantly different (P < 0.001), except for the temporal (P = 0.199) and superotemporal (P = 0.282) sectors. Bland-Altman analysis revealed a global 3.31-µm systematic difference (95% limits of agreement, -7.04 to 13.66); 239 eyes (31.2%) and 63 eyes (8.2%) had a larger than 5-µm and 10-µm difference, respectively. Factors associated with greater absolute measurement differences included higher GMPE RNFL thickness (P < 0.001), lower GMPE scan quality (P = 0.040), and normal-tension glaucoma diagnosis compared to primary open-angle glaucoma (P = 0.028).
Conclusions
Despite excellent correlation, global RNFL thickness and the RNFL thickness of most sectors differed significantly between GMPE and the SGM, sometimes markedly. Clinicians should consider these differences when interpreting or transitioning between modules in the management of glaucoma patients.
Translational relevance: Although highly correlated, GMPE reported thicker global and sectoral RNFL measurements than SGM, which is important when comparing longitudinal OCT follow-up using these modules.
MeSH Terms
Shields Classification
Key Concepts5
Global and sectoral retinal nerve fiber layer (RNFL) thicknesses measured by SPECTRALIS Glaucoma Module Premium Edition (GMPE) and SPECTRALIS Standard Glaucoma Module (SGM) were highly correlated (r ≥ 0.844; ICC ≥ 0.706; P < 0.001 for all) in a cross-sectional study of 766 eyes (465 patients) with glaucoma and glaucoma suspect.
Global and sectoral retinal nerve fiber layer (RNFL) thicknesses between SPECTRALIS Glaucoma Module Premium Edition (GMPE) and SPECTRALIS Standard Glaucoma Module (SGM) were significantly different (P < 0.001), except for the temporal (P = 0.199) and superotemporal (P = 0.282) sectors, in a cross-sectional study of 766 eyes (465 patients) with glaucoma and glaucoma suspect.
Bland-Altman analysis revealed a global 3.31-µm systematic difference (95% limits of agreement, -7.04 to 13.66) in retinal nerve fiber layer (RNFL) thickness between SPECTRALIS Glaucoma Module Premium Edition (GMPE) and SPECTRALIS Standard Glaucoma Module (SGM) in a cross-sectional study of 766 eyes (465 patients) with glaucoma and glaucoma suspect.
In a cross-sectional study of 766 eyes (465 patients) with glaucoma and glaucoma suspect, 239 eyes (31.2%) and 63 eyes (8.2%) had a larger than 5-µm and 10-µm difference, respectively, in retinal nerve fiber layer (RNFL) thickness between SPECTRALIS Glaucoma Module Premium Edition (GMPE) and SPECTRALIS Standard Glaucoma Module (SGM).
Factors associated with greater absolute measurement differences in retinal nerve fiber layer (RNFL) thickness between SPECTRALIS Glaucoma Module Premium Edition (GMPE) and SPECTRALIS Standard Glaucoma Module (SGM) included higher GMPE RNFL thickness (P < 0.001), lower GMPE scan quality (P = 0.040), and normal-tension glaucoma diagnosis compared to primary open-angle glaucoma (P = 0.028) in a cross-sectional study of 766 eyes (465 patients) with glaucoma and glaucoma suspect.
Related Articles5
Longitudinal OCTA vessel density loss in macula and optic nerve head in healthy, glaucoma suspect and established glaucoma eyes.
Cohort StudyDeep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects.
Cohort StudyStandardization of High Myopia Optic Nerve Head Abnormalities May Help Diagnose Glaucoma in High Myopia.
Observational StudyEarly Detection of Primary Open Angle, Angle Closure, and Normal Tension Glaucoma in an Asian Population Using Optical Coherence Tomography.
Cross-Sectional StudyPeripapillary and Macular Vascular Density in Patients With Preperimetric and Early Primary Open Angle Glaucoma.
Cross-Sectional StudyIs this article assigned to the wrong chapter(s)? Let us know.