Anterior chamber particles are associated with reduction of intraocular pressure after selective laser trabeculoplasty.
Kulikov Alexei N, Maltsev Dmitrii S, Kazak Alina A, Burnasheva Maria A
AI Summary
This study found more anterior chamber particles after SLT correlated with greater long-term IOP reduction, suggesting particle count could predict SLT success in glaucoma patients.
Abstract
Purpose
To study the correlation between intraocular pressure (IOP) reduction and the number of hyper-reflective particles appearing in the anterior chamber following selective laser trabeculoplasty (SLT).
Material and methods: In this prospective interventional study, we included primary open-angle glaucoma patients. All participants received a standardised SLT session, which consisted of 100 pulses of 0.9 mJ over 360°. Anterior segment optical coherence tomography (4×4 mm volume scan, 101 horizontal cross-sectional scans) and applanation tonometry were performed before SLT and 15 min, 1 day, 1 week, 1 month and 3 months after. Particles were counted on cross-sectional scans using a standardised algorithm.
Results
In this study, we included 25 patients (25 eyes), 14 males and 11 females, with a mean age of 68.9±10.5 and baseline IOP of 21.4±4.5 mm Hg. IOP at month 1 and month 3 after SLT was 18.0±4.0 and 17.4±3.3 mm Hg, respectively. The mean number of anterior chamber particles before and 15 min after SLT was 0.62±0.2 and 7.1±2.0 particles/mm 2 , respectively (p=0.036). There was a statistically significant correlation between the mean number of anterior chamber particles 15 min after SLT and IOP reduction at 1 month (r=0.62, p=0.03) and 3 months (r=0.71, p=0.01).
Conclusion
The number of the anterior chamber particles graded using anterior segment optical coherence tomography after the procedure correlates with the IOP-lowering effect of SLT.
MeSH Terms
Shields Classification
Key Concepts4
In a prospective interventional study of 25 primary open-angle glaucoma patients (25 eyes), the mean number of anterior chamber particles 15 minutes after selective laser trabeculoplasty (SLT) was 7.1±2.0 particles/mm², compared to 0.62±0.2 particles/mm² before SLT (p=0.036).
In a prospective interventional study of 25 primary open-angle glaucoma patients (25 eyes), there was a statistically significant correlation between the mean number of anterior chamber particles 15 minutes after selective laser trabeculoplasty (SLT) and intraocular pressure (IOP) reduction at 1 month (r=0.62, p=0.03).
In a prospective interventional study of 25 primary open-angle glaucoma patients (25 eyes), there was a statistically significant correlation between the mean number of anterior chamber particles 15 minutes after selective laser trabeculoplasty (SLT) and intraocular pressure (IOP) reduction at 3 months (r=0.71, p=0.01).
In a prospective interventional study of 25 primary open-angle glaucoma patients (25 eyes), the intraocular pressure (IOP) after selective laser trabeculoplasty (SLT) was 18.0±4.0 mm Hg at month 1 and 17.4±3.3 mm Hg at month 3, from a baseline IOP of 21.4±4.5 mm Hg.
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