TAMOXIFEN-INDUCED CHORIORETINAL CHANGES: An Optical Coherence Tomography and Optical Coherence Tomography Angiography Study.
Crisóstomo Sara, Vieira Luísa, Cardigos Joana, Fernandes Diogo H, Luís Maria E, Nunes Susana, Morujão Inês, Anjos Rita, Flores Rita
AI Summary
Tamoxifen treatment causes subclinical retinal and choroidal thinning, suggesting early RPE and photoreceptor damage, highlighting the need for monitoring tamoxifen-induced ocular toxicity.
Abstract
Purpose
To study structural chorioretinal changes in tamoxifen-treated patients.
Methods
Cross-sectional case-control study comparing structural chorioretinal aspects in tamoxifen-treated patients and healthy controls. Enhanced depth spectral domain optic coherence tomography with choroidal binarization and optic coherence tomography angiography were performed. Individual retinal layer thickness and chorioretinal vascular components were compared. Subgroup analysis regarding history of chemotherapy was performed.
Results
Two hundred eyes of 100 TAM-treated patients (Group 1) and 80 eyes of 40 healthy controls (Group 2) were included. Of the 200 spectral domain optic coherence tomography scans from patients, 2 showed structural changes attributable to tamoxifen. Group 1 showed significantly lower values in choroidal parameters and in total retinal, ganglion cell layer, inner plexiform layer, outer nuclear layer, and retinal pigment epithelial thicknesses as well as an increased thickness in the outer plexiform layer. The subgroup not submitted to chemotherapy maintained significant reductions in total retinal thickness, ganglion cell layer, retinal pigment epithelium, outer nuclear layer, outer retinal layer, choroidal parameters, as well as an increased thickness in the outer plexiform layer, in comparison with Group 2.
Conclusion
Subclinical structural retinal changes could indicate early retinal pigment epithelial and photoreceptor damage. The new finding of choroidal thinning could point toward another important pathophysiologic process in tamoxifen-induced toxicity.
MeSH Terms
Shields Classification
Key Concepts5
Tamoxifen-treated patients (Group 1, 200 eyes of 100 patients) showed significantly lower values in choroidal parameters and in total retinal, ganglion cell layer, inner plexiform layer, outer nuclear layer, and retinal pigment epithelial thicknesses as well as an increased thickness in the outer plexiform layer compared to healthy controls (Group 2, 80 eyes of 40 controls).
In a subgroup of tamoxifen-treated patients not submitted to chemotherapy, significant reductions were maintained in total retinal thickness, ganglion cell layer, retinal pigment epithelium, outer nuclear layer, outer retinal layer, and choroidal parameters, along with an increased thickness in the outer plexiform layer, when compared to healthy controls.
Subclinical structural retinal changes observed in tamoxifen-treated patients could indicate early retinal pigment epithelial and photoreceptor damage.
The new finding of choroidal thinning in tamoxifen-treated patients could point toward another important pathophysiologic process in tamoxifen-induced toxicity.
Two out of 200 spectral domain optic coherence tomography scans from tamoxifen-treated patients (Group 1, 200 eyes of 100 patients) showed structural changes attributable to tamoxifen.
Related Articles5
Peripapillary fluid: Obvious and not so obvious!
ReviewNaïve subretinal haemorrhage due to neovascular age-related macular degeneration. pneumatic displacement, subretinal air, and tissue plasminogen activator: subretinal vs intravitreal aflibercept-the native study.
Cohort StudyRapid Macular Thinning Is an Early Indicator of Hydroxychloroquine Retinal Toxicity.
Cohort StudyThe clinical relevance of ultra-widefield angiography findings in patients with central retinal vein occlusion and macular oedema receiving anti-VEGF therapy.
Cohort StudySusac's syndrome - A new ocular finding and disease outcome.
Case SeriesIs this article assigned to the wrong chapter(s)? Let us know.