Macular and submacular choroidal microvasculature in patients with primary open-angle glaucoma and high myopia.
Lin Fengbin, Qiu Zhen, Li Fei, Chen Yu, Peng Yuying, Chen Meiling, Song Yunhe, Xiong Jian, Cheng Weijing, Liu Yuhong
AI Summary
This study found glaucoma and high myopia reduce macular capillary density, especially in the outer retina. Assessing outer superficial plexus density may aid glaucoma diagnosis in high myopia.
Abstract
Aims
To characterise the influence of primary open-angle glaucoma (POAG) and high myopia (HM) on the macular and choroidal capillary density (CD).
Methods
Two hundred and seven eyes were enrolled, including 80 POAG without HM, 50 POAG with HM, 31 HM without POAG and 46 normal controls. A fovea-centred 6×6 mm optical coherence tomography angiography scan was performed to obtain the CD of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris. Macular and choroidal CDs were compared among the groups and the association of CDs with visual field mean deviation (MD) was determined using linear regression models.
Results
Compared with normal eyes, SCP CD was decreased in the POAG without HM group (p<0.05), while DCP CD was significantly decreased in the HM without POAG group (p<0.05). Both SCP and DCP CDs were significantly decreased in the POAG with HM group (p<0.05). CD reduction occurred mainly in the outer rather than inner ring of the 6×6 mm scan size. In multivariate regression analysis, worse MD was associated with lower CD in the outer ring of the SCP in all the HM eyes (p<0.05).
Conclusions
POAG and HM reduced macular CD in different layers of the retinal capillary plexus and both particularly in the outer ring of the 6×6 mm scans. Furthermore, assessment of the CD in the outer ring of the SCP may facilitate the diagnosis of glaucoma in eyes with HM.
MeSH Terms
Shields Classification
Key Concepts6
In a study of 207 eyes, the superficial capillary plexus (SCP) capillary density (CD) was decreased in patients with primary open-angle glaucoma (POAG) without high myopia (HM) compared with normal eyes (p<0.05).
In a study of 207 eyes, the deep capillary plexus (DCP) capillary density (CD) was significantly decreased in patients with high myopia (HM) without primary open-angle glaucoma (POAG) compared with normal eyes (p<0.05).
In a study of 207 eyes, both superficial capillary plexus (SCP) and deep capillary plexus (DCP) capillary densities (CDs) were significantly decreased in patients with primary open-angle glaucoma (POAG) with high myopia (HM) compared with normal eyes (p<0.05).
In a study of 207 eyes, capillary density (CD) reduction in primary open-angle glaucoma (POAG) and high myopia (HM) occurred mainly in the outer rather than inner ring of the 6×6 mm optical coherence tomography angiography scan size.
In a multivariate regression analysis of 207 eyes, worse visual field mean deviation (MD) was associated with lower capillary density (CD) in the outer ring of the superficial capillary plexus (SCP) in all high myopia (HM) eyes (p<0.05).
Assessment of the capillary density (CD) in the outer ring of the superficial capillary plexus (SCP) may facilitate the diagnosis of glaucoma in eyes with high myopia (HM), based on findings from a study of 207 eyes.
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