Ankle-brachial index and ocular diseases in a Russian population.
Bikbov Mukharram M, Gilmanshin Timur R, Zainullin Rinat M, Rakhimova Ellina M, Rusakova Iuliia A, Fakhretdinova Albina A, Tuliakova Azaliia M, Kazakbaeva Gyulli M, Panda-Jonas Songhomitra, Safiullina Kamilia R
AI Summary
This study found no significant association between ankle-brachial index (ABI), a marker of subclinical atherosclerosis, and major ocular diseases like glaucoma or AMD in a Russian population, suggesting no direct link.
Abstract
Background
To assess potential associations between the ankle-brachial blood pressure index (ABI) and ocular disorders.
Methods
In the population-based cross-sectional Russian Ural Eye and Medical Study including 5,899 (80.5%) out of 7328 eligible participants aged 40+ years, the participants underwent a series of ocular and medical examinations including measurement of ABI.
Results
Blood pressure measurements of both arms and ankles were available for 3187 (54.0%) individuals. The mean ABI was 1.26 ± 0.19 (median:1.20; range: 0.61, 2.20). In multivariate analysis, a higher ABI was associated with younger age (P < 0.001; non-standardized regression coefficient B: -0.001; 95% confidence interval (CI): -0.002, -0.001), female sex (P < 0.001; B: 0.03; 95% CI: 0.02, 0.04), lower body mass index (P < 0.001; B: -0.004; 95% CI: -0.006, -0.003), lower waist-to-hip ratio (P = 0.01; B: -0.10; 95% CI: -0.17, -0.02), lower glucose serum concentration (P = 0.008; B: -0.005; 95% CI: -0.009, -0.001), lower prevalence of arterial hypertension (P < 0.001; B: -0.14; 95% CI: -0.16, -0.12), higher mean systolic blood pressure (P < 0.001; B: 0.003; 95% CI: 0.002, 0.003), and higher prevalence of any alcohol consumption (P < 0.001; B: 0.03; 95% CI: 0.02, 0.04). In that multivariate model, prevalence of glaucoma (P = 0.67) as a whole, open-angle glaucoma (P = 0.86) and angle-closure glaucoma (P = 0.54), stage of glaucomatous optic neuropathy (P = 0.57), prevalence of age-related macular degeneration (P = 0.88), prevalence and stage of diabetic retinopathy (P = 0.30, and P = 0.29, respectively), nuclear cataract (P = 0.32, and P = 0.41, resp.), cortical cataract (P = 0.33, and P = 0.92, resp.), subcapsular cataract (P = 0.74 and P = 0.60, resp.), and pseudoexfoliation (P = 0.44 and P = 0.47, resp.), intraocular pressure (P = 0.52), axial length (P = 0.20), and peripapillary retinal nerve fibre layer thickness (P = 0.55) were not significantly associated with the ABI.
Conclusions
In this ethnically mixed population from Russia, none of the major ocular diseases was associated with ABI suggesting that subclinical atherosclerosis is not markedly associated with the aetiology of these ocular disorders.
MeSH Terms
Shields Classification
Key Concepts4
In a multivariate analysis of a population-based cross-sectional study (Russian Ural Eye and Medical Study) involving 3187 individuals, a higher ankle-brachial index (ABI) was associated with younger age (P < 0.001; non-standardized regression coefficient B: -0.001; 95% confidence interval (CI): -0.002, -0.001), female sex (P < 0.001; B: 0.03; 95% CI: 0.02, 0.04), lower body mass index (P < 0.001; B: -0.004; 95% CI: -0.006, -0.003), lower waist-to-hip ratio (P = 0.01; B: -0.10; 95% CI: -0.17, -0.02), lower glucose serum concentration (P = 0.008; B: -0.005; 95% CI: -0.009, -0.001), lower prevalence of arterial hypertension (P < 0.001; B: -0.14; 95% CI: -0.16, -0.12), higher mean systolic blood pressure (P < 0.001; B: 0.003; 95% CI: 0.002, 0.003), and higher prevalence of any alcohol consumption (P < 0.001; B: 0.03; 95% CI: 0.02, 0.04).
In a multivariate analysis of a population-based cross-sectional study (Russian Ural Eye and Medical Study) involving 3187 individuals, the prevalence of glaucoma (P = 0.67), open-angle glaucoma (P = 0.86), angle-closure glaucoma (P = 0.54), stage of glaucomatous optic neuropathy (P = 0.57), prevalence of age-related macular degeneration (P = 0.88), prevalence and stage of diabetic retinopathy (P = 0.30, and P = 0.29, respectively), nuclear cataract (P = 0.32, and P = 0.41, resp.), cortical cataract (P = 0.33, and P = 0.92, resp.), subcapsular cataract (P = 0.74 and P = 0.60, resp.), pseudoexfoliation (P = 0.44 and P = 0.47, resp.), intraocular pressure (P = 0.52), axial length (P = 0.20), and peripapillary retinal nerve fibre layer thickness (P = 0.55) were not significantly associated with the ankle-brachial index (ABI).
In an ethnically mixed population from Russia, major ocular diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, cataract, pseudoexfoliation, intraocular pressure, axial length, and peripapillary retinal nerve fibre layer thickness were not associated with the ankle-brachial index (ABI), suggesting that subclinical atherosclerosis is not markedly associated with the etiology of these ocular disorders.
In a population-based cross-sectional study of 3187 individuals aged 40+ years from the Russian Ural Eye and Medical Study, the mean ankle-brachial index (ABI) was 1.26 0.19 (median: 1.20; range: 0.61, 2.20).
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