Wide-field optical coherence tomography deviation map for early glaucoma detection.
Kim Hyungjun, Park Hae Min, Jeong Hyo Chan, Moon So Yeon, Cho Hyunsoo, Lim Han Woong, Seong Mincheol, Park Junhong, Lee Won June
AI Summary
This study found a new wide-field OCT deviation map significantly improves early glaucoma detection by visualizing wider structural damage, offering a valuable clinical diagnostic tool.
Abstract
Background/aims: This study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).
Methods
Four hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT (DRI-OCT Triton; Topcon, Tokyo, Japan). The individual wide-field scan was converted into a uniform template using the fovea and optic disc centres as fixed landmarks. Subsequently, the wide-field deviation map was obtained via the comparison between individual wide-field data and a normative wide-field database that had been created by combining images of healthy eyes into a uniform template in a previous study. The ability of the new wide-field deviation map to distinguish between EG and healthy eyes was assessed by comparing it with conventional deviation maps based on the area under the receiver operating characteristic curve (AUC).
Results
The wide-field deviation map obtained using the normative wide-field database showed the highest diagnostic ability for the diagnosis of EG (AUC=0.980 and 961 for colour-coded pixels presenting <5% and <1%, respectively) among various deviation maps. Its AUC was significantly superior to that of most conventional deviation maps (p<0.05). The wide-field deviation map demonstrated early structural glaucomatous damage well over a wider area.
Conclusion
The wide-field SS-OCT deviation map exhibited good performance for distinguishing between eyes with EG and healthy eyes. The visualisation of the wider damaged area on the wide-field deviation map could be useful for the diagnosis of EG in clinical settings.
MeSH Terms
Shields Classification
Key Concepts5
The wide-field deviation map obtained using the normative wide-field database showed the highest diagnostic ability for the diagnosis of early glaucoma (EG) with an AUC=0.980 for colour-coded pixels presenting <5% and AUC=0.961 for colour-coded pixels presenting <1%.
The AUC of the wide-field deviation map was significantly superior to that of most conventional deviation maps (p<0.05) for distinguishing between early glaucoma (EG) and healthy eyes.
The wide-field SS-OCT deviation map exhibited good performance for distinguishing between eyes with early glaucoma (EG) and healthy eyes.
The visualisation of the wider damaged area on the wide-field deviation map could be useful for the diagnosis of early glaucoma (EG) in clinical settings.
A wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans was established to detect early glaucoma (EG).
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