Effects of Physiologic Myopia and Aging on Visual Fields in Normal Eyes.
Iwase Aiko, Fujii Makoto, Murata Hiroshi, Ohno Yuko, Araie Makoto
AI Summary
This study found that myopia lowers visual field sensitivity, but doesn't accelerate age-related visual field decline, which itself worsens with age in normal eyes.
Abstract
Purpose
The purpose of this study was to investigate how mild-to-moderate myopia and aging affect visual field sensitivity (VF-S) in normal eyes, correcting for effects of each.
Design
Combined cross-sectional and cohort study.
Methods
Two normal groups, a cross-sectional group (n = 703; 1,051 eyes; mean age, 52.6 years) and a longitudinal group (n = 44; 83 eyes; mean age, 52.3 years; follow-up, 4.2 years; VF tests, 12) were included. In the cross-sectional group, the mean VF-S of the entire field and 3 disc portion-oriented subfields of the Humphrey Field Analyzer 24-2 program were correlated with subjects' age, axial length (AL), disc, rim and β-peripapillary area, and disc ovality and torsion, using linear mixed-regression models. Their time changes in the longitudinal group were correlated with time, subjects' ages, and AL using linear mixed-regression models.
Results
In the cross-sectional group, the VF-S correlated negatively with age (-0.081 decibel [dB]/year; P < .001), which was more negative (P = .020) in the midperipheral than the central subfield, and with AL (P = .049) without intersubfield differences. In the longitudinal group, no changes in the ocular media were significant, and the VF-S declined by 0.074 dB/year (P = .007), which accelerated with higher age (P < .002) and baseline VF-S (P < .001) without intersubfield differences. The AL showed little effects on the VF-S longitudinal changes.
Conclusions
In normal eyes with mild-to-moderate myopia, the VF-S was lower subfield-independently with longer AL, whereas the AL had little effect on the aging-associated VF-S reduction. The VF-S decreased with aging with intersubfield differences. The aging-associated VF-S reduction accelerated with higher age, to which the ocular media changes were unrelated.
MeSH Terms
Shields Classification
Key Concepts4
In normal eyes with mild-to-moderate myopia, visual field sensitivity (VF-S) correlated negatively with axial length (AL) (P = .049) without intersubfield differences, based on a cross-sectional study of 703 subjects (1,051 eyes) with a mean age of 52.6 years.
In normal eyes with mild-to-moderate myopia, visual field sensitivity (VF-S) correlated negatively with age (-0.081 decibel [dB]/year; P < .001), with the decline being more negative (P = .020) in the midperipheral than the central subfield, based on a cross-sectional study of 703 subjects (1,051 eyes) with a mean age of 52.6 years.
In normal eyes with mild-to-moderate myopia, visual field sensitivity (VF-S) declined by 0.074 dB/year (P = .007), which accelerated with higher age (P < .002) and baseline VF-S (P < .001) without intersubfield differences, based on a longitudinal study of 44 subjects (83 eyes) with a mean age of 52.3 years and a follow-up of 4.2 years.
In normal eyes with mild-to-moderate myopia, axial length (AL) had little effect on the aging-associated visual field sensitivity (VF-S) reduction, based on a longitudinal study of 44 subjects (83 eyes) with a mean age of 52.3 years and a follow-up of 4.2 years.
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