In-vivo imaging of the conventional aqueous outflow system.
Lee Daniel, Kolomeyer Natasha N, Razeghinejad Reza, Myers Jonathan S
AI Summary
In-vivo imaging now reveals real-time, dynamic changes in the eye's aqueous outflow system. This advances understanding of glaucoma's cause and treatment, moving beyond ex-vivo studies.
Abstract
Purpose of review: The aim of this study was to provide a comprehensive summary of in-vivo imaging techniques of the aqueous outflow system and discuss its role in improving our understanding of glaucoma pathogenesis and management.
Recent findings: Our understanding of the aqueous outflow system is largely derived from ex-vivo studies. Recent innovations in imaging technology and techniques enable in-vivo evaluation of the conventional outflow system in real-time. Optical coherence tomography allows for noninvasive, high-resolution, volumetric imaging of ocular tissues. Dynamic structural changes have been observed at the trabecular meshwork and Schlemm's canal. In parallel, aqueous angiography using injected tracers show a similar dynamism with variable and pulsatile flow signals.
Summary
In-vivo imaging enable real-time evaluation of the conventional aqueous outflow pathway. This emerging field shows great promise to expand our understanding of the pathogenesis and treatment of glaucoma.
MeSH Terms
Shields Classification
Key Concepts6
Recent innovations in imaging technology and techniques enable in-vivo evaluation of the conventional outflow system in real-time.
Optical coherence tomography allows for noninvasive, high-resolution, volumetric imaging of ocular tissues, specifically observing dynamic structural changes at the trabecular meshwork and Schlemm's canal.
Aqueous angiography using injected tracers shows similar dynamism with variable and pulsatile flow signals in the aqueous outflow system.
In-vivo imaging enables real-time evaluation of the conventional aqueous outflow pathway, showing great promise to expand our understanding of the pathogenesis and treatment of glaucoma.
The aim of this review was to provide a comprehensive summary of in-vivo imaging techniques of the aqueous outflow system and discuss its role in improving the understanding of glaucoma pathogenesis and management.
Our understanding of the aqueous outflow system is largely derived from ex-vivo studies.
Related Articles5
Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response.
Basic ScienceFunctional Assessment of Aqueous Humor Outflow by Aqueous Angiography in Primary Open Angle Glaucoma.
Cross-Sectional StudyThe aqueous humour dynamics in primary angle closure disease: a computational study.
Basic ScienceQuantitative Assessment of Functional Aqueous Humor Outflow by Aqueous Angiography.
Cross-Sectional StudyIn Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics.
Basic ScienceIs this article assigned to the wrong chapter(s)? Let us know.