Patterns of Optical Coherence Tomography Imaging in Preperimetric Open Angle Glaucoma: A Comparative Study With Young-Age-Onset and Old-Age-Onset Eyes.
Bak Eunoo, Sun Sukkyu, Wy Seoyoung, Kim Yong Woo, Kim Young Kook, Park Ki Ho, Kim Hee Chan, Jeoung Jin Wook
AI Summary
This study found preperimetric glaucoma causes different nerve thinning patterns (inferior for young, superior for old) based on age-of-onset, which can improve diagnosis and monitoring.
Abstract
Prcis: Optic coherence tomography imaging in preperimetric open angle glaucoma (OAG) differed between young-age-onset and old-age-onset eyes. Inferior and superior quadrants were thinner in young and old-age-onset eyes, respectively. Understanding the specific patterns of early glaucomatous damage based on age-at-onset may improve glaucoma diagnosis and monitoring.
Purpose
To investigate the patterns of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thinning in preperimetric OAG by optical coherence tomography based on age at onset ("young-age onset (<40 y)" vs. "old-age onset (≥40 y)".
Materials and methods
The RNFL and GCIPL deviation images were acquired by Cirrus HD-optical coherence tomography, and overlaid, thus converted to a "deviation frequency map", respectively. The topographic thinning patterns and parameters of RNFL and GCIPL thickness measurements were compared.
Results
A total of 194 eyes of 194 patients with preperimetric OAG and 97 eyes of 97 age-matched normal subjects were analyzed. Young-age-onset eyes of preperimetric OAG mainly had RNFL defects inferotemporally (264-296 degrees) with GCIPL defects in the inferior region (213-357 degrees). Old-age-onset preperimetric OAG eyes had RNFL defects inferotemporally (266-294°) and superotemporally (33-67 degrees), with GCIPL defects in the inferior and superior regions (206-360 degrees, 0-22 degrees). The inferior quadrant of RNFL and GCIPL thicknesses were significantly thinner in young-age-onset eyes compared with old-age-onset eyes ( P =0.012, 0.016), while the superior quadrant of those were significantly thinner in the old-age-onset eyes ( P =0.003, 0.005).
Conclusion
Young-age-onset and old-age-onset eyes of preperimetric OAG present different specific patterns of RNFL and GCIPL thinning.
MeSH Terms
Shields Classification
Key Concepts5
Young-age-onset eyes (<40 years) with preperimetric open angle glaucoma (OAG) mainly had retinal nerve fiber layer (RNFL) defects inferotemporally (264-296 degrees) with macular ganglion cell-inner plexiform layer (GCIPL) defects in the inferior region (213-357 degrees).
Old-age-onset eyes (≥40 years) with preperimetric open angle glaucoma (OAG) had retinal nerve fiber layer (RNFL) defects inferotemporally (266-294°) and superotemporally (33-67 degrees), with macular ganglion cell-inner plexiform layer (GCIPL) defects in the inferior and superior regions (206-360 degrees, 0-22 degrees).
The inferior quadrant of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were significantly thinner in young-age-onset eyes (<40 years) compared with old-age-onset eyes (≥40 years) with preperimetric open angle glaucoma (OAG) (P = 0.012 for RNFL, P = 0.016 for GCIPL).
The superior quadrant of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were significantly thinner in old-age-onset eyes (≥40 years) compared with young-age-onset eyes (<40 years) with preperimetric open angle glaucoma (OAG) (P = 0.003 for RNFL, P = 0.005 for GCIPL).
A total of 194 eyes of 194 patients with preperimetric open angle glaucoma (OAG) and 97 eyes of 97 age-matched normal subjects were analyzed in a comparative study investigating patterns of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thinning.
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