Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma.
Sato Kota, Takada Naoko, Fujioka Amane, Himori Noriko, Yokoyama Yu, Tsuda Satoru, Omodaka Kazuko, Kirihara Tomoko, Ishikawa Makoto, Kunikata Hiroshi
AI Summary
This study found plasma BDNF levels were significantly lower in normal tension glaucoma than open-angle glaucoma, suggesting low BDNF may contribute to glaucoma pathogenesis independent of eye pressure.
Abstract
Précis: The study suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner.
Aims
To evaluate differences in systemic brain-derived neurotrophic factor (BDNF) levels between primary open angle glaucoma (POAG) patients and normal tension glaucoma (NTG) patients.
Methods
This study collected blood samples from 260 NTG patients, 220 age-matched POAG patients, and 120 age-matched cataract patients (as controls). BDNF levels were measured with an antibody-conjugated bead assay system (Luminex).
Results
We found that plasma BDNF levels in the NTG group were significantly lower than in the POAG and cataract control groups. There was no significant difference between the POAG and cataract groups.
Conclusion
This result suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner.
MeSH Terms
Shields Classification
Key Concepts3
Plasma brain-derived neurotrophic factor (BDNF) levels in the normal tension glaucoma (NTG) group (n=260) were significantly lower than in the primary open angle glaucoma (POAG) group (n=220) and cataract control groups (n=120).
There was no significant difference in plasma brain-derived neurotrophic factor (BDNF) levels between the primary open angle glaucoma (POAG) group (n=220) and the cataract control group (n=120).
A low level of systemic brain-derived neurotrophic factor (BDNF) may contribute to the pathogenesis of glaucoma in an intraocular pressure (IOP)-independent manner.
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