Kunikata Hiroshi

Ninomiya Takahiro, Kiyota Naoki, Sharma Parmanand, Omodaka Kazuko, Himori Noriko, Yasuda Masayuki et al.

AI-assisted OCTA-measured FAZ changes correlated with inferocentral visual field defect progression in glaucoma. This suggests FAZ parameters could be valuable markers for monitoring disease worsening.

Sato Kota, Takada Naoko, Fujioka Amane, Himori Noriko, Yokoyama Yu, Tsuda Satoru et al.

This study found plasma BDNF levels were significantly lower in normal tension glaucoma than open-angle glaucoma, suggesting low BDNF may contribute to glaucoma pathogenesis independent of eye pressure.

Ninomiya Takahiro, Kunikata Hiroshi, Ishikawa Makoto, Nakazawa Toru

Nishiguchi Koji M, Kunikata Hiroshi, Fujita Kosuke, Hashimoto Kazuki, Koyanagi Yoshito, Akiyama Masato et al.

CRX gene mutations cause variable retinal dystrophies, often with electronegative ERGs, even in asymptomatic carriers. Consider CRX testing for patients with unexplained electronegative ERGs.

Kiyota Naoki, Shiga Yukihiro, Yasuda Masayuki, Aizawa Naoko, Omodaka Kazuko, Tsuda Satoru et al.

This pilot study found weaker optic nerve head vasoreactivity to oxygen, measured by laser speckle flowgraphy, was linked to faster visual field loss in glaucoma, suggesting a potential progression biomarker.

Nishiguchi Koji M, Ikeda Yasuhiro, Fujita Kosuke, Kunikata Hiroshi, Akiho Makoto, Hashimoto Kazuki et al.

This study found S-antigen mutations cause both Oguchi disease and retinitis pigmentosa (RP). Oguchi disease patients maintain good vision, but some can progress to RP, highlighting a phenotypic spectrum.

Kiyota Naoki, Shiga Yukihiro, Yasuda Masayuki, Aizawa Naoko, Omodaka Kazuko, Tsuda Satoru et al.

This study found sectoral optic nerve blood flow correlates with visual field defects and predicts progression, suggesting LSFG and systemic factors could help clinicians predict glaucoma severity and progression.

Aizawa Naoko, Kunikata Hiroshi, Nakazawa Toru

Kokubun Taiki, Tsuda Satoru, Kunikata Hiroshi, Himori Noriko, Yokoyama Yu, Omodaka Kazuko et al.

AS-OCT bleb wall reflectivity at one week post-trabeculectomy for neovascular glaucoma predicts surgical success, offering an early indicator for managing this challenging condition.

Kiyota Naoki, Shiga Yukihiro, Ichinohasama Kohei, Yasuda Masayuki, Aizawa Naoko, Omodaka Kazuko et al.

This study found ONH blood flow reacts differently than choroidal flow to IOP elevation, demonstrating ONH autoregulation. LSFG offers a reproducible way to assess dynamic ocular blood flow changes, aiding glaucoma research.

Nishiguchi Koji M, Yokoyama Yu, Kunikata Hiroshi, Abe Toshiaki, Nakazawa Toru

Aqueous flare, a marker of inflammation, is elevated in retinitis pigmentosa (RP) and correlates with visual field loss. This suggests flare may reflect the overall retinal degeneration in RP, not just foveal issues.

Kiyota Naoki, Kunikata Hiroshi, Shiga Yukihiro, Omodaka Kazuko, Nakazawa Toru

This study found LSFG's MT useful for early glaucoma detection, while OCTA's auto R3 VD effectively identifies moderate to advanced stages, offering complementary microcirculation assessments for glaucoma management.

Yamada Erika, Himori Noriko, Kunikata Hiroshi, Omodaka Kazuko, Ogawa Hiromasa, Ichinose Masakazu et al.

Glaucoma patients with sleep apnea showed higher oxidative stress and faster visual field progression, suggesting sleep apnea-induced oxidative stress accelerates glaucoma.

Kiyota Naoki, Kunikata Hiroshi, Takahashi Seri, Shiga Yukihiro, Omodaka Kazuko, Nakazawa Toru

This study found deep microcirculation (PPA-CI) in peripapillary atrophy relates to age, axial length, and visual function in myopic NTG, suggesting it's a biomarker for parafoveal scotoma.

Kiyota Naoki, Shiga Yukihiro, Suzuki Shiori, Sato Marika, Takada Naoko, Maekawa Shigeto et al.

Glaucoma patients showed a weaker optic nerve head blood flow response to hyperoxia than controls, suggesting impaired vasoreactivity. This indicates potential pre-existing vasoconstriction or altered regulatory pathways in glaucoma.

Kiyota Naoki, Kunikata Hiroshi, Shiga Yukihiro, Omodaka Kazuko, Nakazawa Toru

This study found OCTA's PRI correlated with LSFG's MBR in glaucoma, suggesting PRI is a promising biomarker for ocular microcirculation changes in diseases like glaucoma.

Himori Noriko, Kunikata Hiroshi, Inoue Maki, Takeshita Takayuki, Nishiguchi Koji M, Nakazawa Toru

Sato Haruka, Kunikata Hiroshi, Ouchi Junko, Nakazawa Toru

Himori Noriko, Kunikata Hiroshi, Kawasaki Ryo, Shiga Yukihiro, Omodaka Kazuko, Takahashi Hidetoshi et al.

This study found systemic oxidative stress (SAF) correlates with visual field loss in younger glaucoma patients, suggesting antioxidant therapies may be more beneficial for this age group.

Inoue Maki, Himori Noriko, Kunikata Hiroshi, Takeshita Takayuki, Aizawa Naoko, Shiga Yukihiro et al.

ADOA patients showed significantly reduced temporal optic nerve blood flow and nerve fiber thickness, suggesting specific damage to the papillomacular bundle, which may be particularly vulnerable to mitochondrial dysfunction.

Kokubun Taiki, Kunikata Hiroshi, Tsuda Satoru, Himori Noriko, Maruyama Kazuichi, Nakazawa Toru

AS-OCT bleb structure, particularly early horizontal brightness, correlates with post-trabeculectomy IOP. This offers a potential tool to predict surgical success.

Yui Rieko, Kunikata Hiroshi, Aizawa Naoko, Nakazawa Toru

Kunikata Hiroshi, Nakazawa Toru

LSFG, measuring mean blur rate, non-invasively quantifies ocular blood flow changes in retinal diseases, offering a reproducible tool to evaluate microcirculation in vessels, choroid, and optic nerve head.

Himori Noriko, Kunikata Hiroshi, Shiga Yukihiro, Omodaka Kazuko, Maruyama Kazuichi, Takahashi Hidetoshi et al.

This study found that systemic oxidative stress biomarkers correlate with reduced ocular blood flow and disease severity in normal-tension glaucoma, suggesting oxidative stress contributes to NTG pathogenesis.

Tsuda Satoru, Kunikata Hiroshi, Yamanari Masahiro, Nakazawa Toru